IL‐7 suppresses macrophage autophagy and promotes liver pathology in <i>Schistosoma japonicum</i>‐infected mice

Zhu, Jing; Zhang, Weiwei; Zhang, Lina; Xu, Lei; Chen, Xiaojun; Zhou, Sha; Xu, Zhipeng; Xiao, Ming; Bai, Hui; Liu, Feng; Su, Chuan

doi:10.1111/jcmm.13610

Cited by 28 publications

(27 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the liver pathology was significantly repressed when macrophage autophagy was increased by anti-CD127 blocking antibody treatment or anti-IL-7 neutralizing antibody. This effect of IL-7 was allowed through activation of AMPK [ 133 ]. More recently, Jian et al (2019), purposed the involvement of IL-7 in blocking autophagy in human lung cancer cells (A549 and H460 cell lines).…”

Section: Myokines and Autophagymentioning

confidence: 99%

Irisin and Autophagy: First Update

Pesce

Ballerini

Paolucci

et al. 2020

IJMS

View full text Add to dashboard Cite

Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular proteins and organelles. This process is a part of the molecular underpinnings by which exercise promotes healthy aging and mitigate age-related pathologies. Irisin is a myokine released during physical activity and acts as a link between muscles and other tissues and organs. Its main beneficial function is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin modulates metabolic processes, acting on glucose homeostasis, reduces systemic inflammation, maintains the balance between resorption and bone formation, and regulates the functioning of the nervous system. Recently, some of its pleiotropic and favorable properties have been attributed to autophagy induction, posing irisin as an important regulator of autophagy by exercise. This review article proposes to bring together for the first time the “state of the art” knowledge regarding the effects of irisin and autophagy. Furthermore, treatments on relation between exercise/myokines and autophagy have been also achieved.

show abstract

Section: Myokines and Autophagymentioning

confidence: 99%

Irisin and Autophagy: First Update

Pesce

Ballerini

Paolucci

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Much less is understood about formation of HIV latency in these cell subsets. Macrophages express CD127 and antibody blocking of this pathway increases autophagy (152). How this process would impact the HIV persistence is unclear.…”

Section: Specific Considerations/limitationsmentioning

confidence: 99%

Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure

et al. 2019

View full text Add to dashboard Cite

Recent studies demonstrate that the stable HIV-1 reservoir in resting CD4 + T cells is mostly formed from viruses circulating when combination antiretroviral therapy (ART) is initiated. Here we explore the immunological basis for these observations. Untreated HIV-1 infection is characterized by a progressive depletion of memory CD4 + T cells which mostly express CD127, the α chain of the IL-7 receptor (IL-7R). Depletion results from both direct infection and bystander loss of memory CD4 + T cells in part attributed to dysregulated IL-7/IL-7R signaling. While IL-7/IL7R signaling is not essential for the generation of effector CD4 + T cells from naïve cells, it is essential for the further transition of effectors to memory CD4 + T cells and their subsequent homeostatic maintenance. HIV-1 infection therefore limits the transition of CD4 + T cells from an effector to long-lived memory state. With the onset of ART, virus load (VL) levels rapidly decrease and the frequency of CD127 + CD4 + memory T cells increases, indicating restoration of effector to memory transition in CD4 + T cells. Collectively these data suggest that following ART initiation, HIV-1 infected effector CD4 + T cells transition to long-lived, CD127 + CD4 + T cells forming the majority of the stable HIV-1 reservoir. We propose that combining ART initiation with inhibition of IL-7/IL-7R signaling to block CD4 + T cell memory formation will limit the generation of long-lived HIV-infected CD4 + T cells and reduce the overall size of the stable HIV-1 reservoir.

show abstract

“…Impairment of metabolic reprogramming by SIRT1 or AMPK suppresses intracellular growth of the parasite, suggesting a role for AMPK/SIRT1 in intracellular proliferation of L. infantum [ 90 ]. In Schistosoma japonicum egg antigen (SEA)-mediated autophagy, which is modulated by IL-7 and the AMPK signaling pathway, ameliorate liver pathology, suggesting AMPK to be a therapeutic target factor for schistosomiasis [ 91 ].…”

Section: Multifaceted Role Of Ampk In Antimicrobial Responsesmentioning

confidence: 99%

AMP-Activated Protein Kinase and Host Defense against Infection

Silwal

Kim

Yuk

et al. 2018

IJMS

View full text Add to dashboard Cite

5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections. In addition, this review focuses on the double-edged role of AMPK in innate and adaptive immune responses to infection. Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases.

show abstract

IL‐7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum‐infected mice

Cited by 28 publications

References 28 publications

Irisin and Autophagy: First Update

Irisin and Autophagy: First Update

Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure

AMP-Activated Protein Kinase and Host Defense against Infection

Contact Info

Product

Resources

About