IL-7–dependent and –independent lineages of IL-7R–dependent human T cells
Carlos A. Arango-Franco,
Masato Ogishi,
Susanne Unger
et al.
Abstract:Infants with biallelic
IL7R
loss-of-function variants have severe combined immune deficiency (SCID) characterized by the absence of autologous T lymphocytes, but normal counts of circulating B and NK cells (T
–
B
+
NK
+
SCID). We report 6 adults (aged 22 to 59 years) from 4 kindreds and 3 ancestries (Colombian, Israeli Arab, Japanese) carrying homozygous
IL7
loss-of-function variants resulting in … Show more
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