IL-6 Polymorphisms Are Not Related to Obesity Parameters in Physically Active Young Men

Maculewicz, Ewelina; Antkowiak, Bożena; Antkowiak, Oktawiusz; Mastalerz, Andrzej; Białek, Agnieszka; Cywińska, Anna; Borecka, Anna; Humińska-Lisowska, Kinga; Garbacz, Aleksandra; Lorenz, Katarzyna; Szarska, Ewa; Michałowska–Sawczyn, Monika; Dziuda, Łukasz

doi:10.3390/genes12101498

Cited by 13 publications

(5 citation statements)

References 31 publications

(50 reference statements)

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“…Boeta-Lopez et al studied antiinflammatory, anti-obesity and glucose homeostatic roles of IL-6 polymorphisms and showed a relation between C allele of rs1800796 with obesity but not with rs1800797 (Boeta-Lopez, 2017). Although no association of rs1800795 and rs1800796 was found in colorectal cancer for which obesity is a risk factor, a study suggests that IL-6 polymorphisms are significant in severely affected patients but not in low-grade obesity (Maculewicz, 2021). Similar to our study, Bustamante et al emphasized the importance of IL-6R SNPs and showed that IL-6R, rs4845617, GG genotype was associated with increase of BMI and obesity in females (Bustamante, 2007).…”

Section: Resultssupporting

confidence: 86%

Investigation of the Relationship between IL-6, IL-6R and CXCL5 Polymorphisms and Obesity in Denizli Province of Turkey

Arıkan¹,

Demirel²

2022

GenApp

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Obesity and its effects on increasing morbidity and mortality have reached the level of an epidemic with a high frequency in modern populations. IL-6 released from adipose tissue is known to trigger the chronic inflammation in obesity. CXCL5, which mediates the activation and migration of neutrophils, has been found at high levels in obese subjects. In our study, we aimed to investigate the possible effects of IL-6, IL-6R and CXCL5, polymorphisms and haplotypes on the development of obesity. We studied IL-6, rs2069827 (-1363, G/T), rs1800797 (-597, G/A), rs1800796 (-572, G/C) and rs1800795 (-174, G/C), IL-6R rs4845617 (-183, G/A), rs2228145 (+48892, A/C) and CXCL5 rs352046 (-156, G/C) polymorphic sites in 60 obesity patients and 59 healthy controls. For genotyping we used PCR-RFLP based approach. The IL-6 rs1800796, rs1800795 and IL-6R rs4845617 G allelles could be the possible genetic factors responsible for obesity. We found similar results in female obese group. The results indicated that there was no association between obesity and other SNPs (rs2069827, rs1800797, and rs1800795 and rs2228145) and CXCL5, rs352046. The results of IL-6 and IL-6R haplotype analysis by global differentiation test showed that haplotypes may have different distributions between obese and controls. Our results showed that polymorphisms and possible haplotypes in IL-6 and IL-6R genes, which have an important role in inflammation, may affect the development of obesity. This study points out the necessity of investigating the possible effects of gene polymorphisms of other cytokines and their receptors in the development of obesity in larger populations.

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Section: Resultssupporting

confidence: 86%

Investigation of the Relationship between IL-6, IL-6R and CXCL5 Polymorphisms and Obesity in Denizli Province of Turkey

Arıkan¹,

Demirel²

2022

GenApp

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“…In another report, the same authors showed a relationship between weight loss and a decrease in TNF-α mRNA levels ( p < 0.001) and, interestingly, increased IL-6 expression ( p < 0.01) in blood mononuclear cells [ 33 ]. The latter result was unexpected and probably related to the pleiotropic effect of interleukin 6, which has pro- and anti-inflammatory effects and is also referred to as the “metabolic hormone” involved in immune responses related to glucose, protein, or lipid metabolism [ 54 ]. Our study showed no significant changes in the IL-6 expression levels in WBCs after 4 weeks and after 12 weeks of the weight loss program.…”

Section: Discussionmentioning

confidence: 99%

Initial Weight Loss, Anthropometric Parameters, and Proinflammatory Transcript Levels in Patients with Class I Obesity

Jabłonowska-Lietz,

Nowicka,

Włodarczyk

et al. 2023

Biomedicines

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Research into early predictors of effective weight loss could help determine more effective therapeutic interventions. In this study, 106 subjects with class I obesity, genotyped with the fat mass and obesity-associated (FTO) rs9930506 gene variant, were enrolled into a 12-week weight loss program (WLP). Anthropometric and body composition measurements were controlled with bioelectrical impedance analysis (BIA) at baseline and after 4 and 12 weeks. Biopsies of abdominal subcutaneous adipose tissue (AT) and venous blood samples were collected to monitor changes in interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-κB) mRNA levels in white blood cells (WBCs) and to assess if changes in WBC gene expression reflected changes in adipose tissue. The FTO rs9930506 variant had no effect on weight loss and no reduction in proinflammatory transcripts in WBCs or AT. Changes in anthropometric parameters were associated with changes in carbohydrate metabolism. A linear regression model showed that initial weight loss (after 4 weeks of the WLP) was the most predictive factor of weight loss success after 12 weeks of the WLP. Changes in plasma lipids or proinflammatory transcript levels in WBCs or AT were not associated with weight loss effectiveness. However, the gene expression in WBCs did reflect changes occurring in subcutaneous AT.

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“…In the obese adipose tissue, IL‐6 is associated with a proinflammatory state, which deteriorates insulin sensitivity and provokes obesity‐associated morbidities 7 . However, there is a lack of correlation between obesity parameters and IL6 polymorphisms in human, 84 and the lack of Il6 increases obesity development in mouse 85 . Moreover, IL‐6 stimulates adipocyte lipolysis, fatty acid oxidation, and mitobiogenesis, hence promotes beige adipocyte development 13,86,87 …”

Section: Il‐6 and Stat3 Signaling In The Infant Adipose Tissuementioning

confidence: 99%

Metabolic impact of adipose tissue macrophages in the early postnatal life

Röszer

2022

Journal of Leukocyte Biology

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Adipose tissue macrophages (ATMs) play key roles in metabolic inflammation, insulin resistance, adipose tissue fibrosis, and immune disorders associated with obesity. Research on ATM biology has mostly been conducted in the setting of adult obesity, since adipocyte hypertrophy is associated with a significant increase in ATM number. Signals that control ATM activation toward a proinflammatory or a proresolving phenotype also determine the developmental program and lipid metabolism of adipocytes after birth. ATMs are present at birth and actively participate in the synthesis of mediators, which induce lipolysis, mitobiogenesis, and mitochondrial uncoupling in adipocytes. ATMs in the newborn and the infant promote a lipolytic and fatty acid oxidizing adipocyte phenotype, which is essential to support the lipid‐fueled metabolism, to maintain nonshivering thermogenesis and counteract an excessive adipose tissue expansion. Since adipose tissue metabolism in the early postnatal life determines obesity status in adulthood, early‐life ATM functions may have a life‐long impact.

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IL-6 Polymorphisms Are Not Related to Obesity Parameters in Physically Active Young Men

Cited by 13 publications

References 31 publications

Investigation of the Relationship between IL-6, IL-6R and CXCL5 Polymorphisms and Obesity in Denizli Province of Turkey

Investigation of the Relationship between IL-6, IL-6R and CXCL5 Polymorphisms and Obesity in Denizli Province of Turkey

Initial Weight Loss, Anthropometric Parameters, and Proinflammatory Transcript Levels in Patients with Class I Obesity

Metabolic impact of adipose tissue macrophages in the early postnatal life

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