IL-6, IL-8 and IL-10 Levels in Healthy Weight and Overweight Children

Tam, Charmaine S.; Garnett, Sarah P.; Cowell, Christopher T.; Heilbronn, Leonie K.; Lee, Jennifer W.; Wong, Melanie; Baur, Louise A.

doi:10.1159/000277632

Cited by 62 publications

(65 citation statements)

References 95 publications

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“…(3). This hypothesis has partially been proven by a longitudinal study of 118 healthy children, which found raised IL6 levels in 15-year-old overweight/obese girls with no difference at the age of 8 years (34). In our prepubertal group, the concentrations of all investigated inflammatory markers did not show significant gender differences and thus confirmed other international reports in children (15,18,25).…”

Section: Discussionsupporting

confidence: 91%

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Galcheva¹,

Iotova²,

Yotov

et al. 2011

European Journal of Endocrinology

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Objectives: To analyze the circulating levels of proinflammatory peptides in healthy prepubertal children in relation to abdominal obesity, measured by waist circumference (WC), and to investigate their interactions with cardiometabolic risk factors. Design and methods: A cross-sectional study of 137 healthy prepubertal children with a mean age of 8.0G0.1 years divided into three groups according to their WC as a measure of abdominal obesity: 'normal-WC' children (25th-75th percentile, nZ48), 'children at risk' (75th-90th percentile, nZ39), and 'abdominally obese' (R90th percentile, nZ50) children. Auxological measurements and blood pressure (BP) were taken. Fasting levels of high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL6), tumor necrosis factor-a (TNF-a), glucose, insulin, and lipid profile were measured. Insulin resistance (IR) was assessed by homeostasis model assessment of IR (HOMA-IR). Results: Abdominally obese children had significantly higher BP, insulin, HOMA-IR, total cholesterol and triglycerides (TG) compared with their normal-WC counterparts (P!0.05). HsCRP concentrations increased proportionally with the degree of abdominal obesity (rZ0.443, P!0.0001), whereas IL6 and TNF-a were not significantly associated with any of the adiposity variables. After controlling for adiposity, hsCRP was significantly correlated with systolic BP (rZ0.257, PZ0.004), TNF-a levels were related to high-density lipoprotein cholesterol (HDL-C; rZK0.216, PZ0.016) and TG (rZ0.196, PZ0.029), whereas the relationship between IL6 and HDL-C reduced its magnitude to an insignificant level (rZK0.173, PZ0.055). Conclusions: Healthy prepubertal children with abdominal obesity have associated inflammatory and cardiometabolic alterations, interacting with each other.

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Section: Discussionsupporting

confidence: 91%

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Galcheva¹,

Iotova²,

Yotov

et al. 2011

European Journal of Endocrinology

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“…At the same time, subtle differences in inflammatory mediators may also have been missed due to the relatively small groups with a wide age-range. For example, we were unable to confirm the increased IL-10 levels previously observed in obese adolescent girls [18]. Moreover, based on previous studies [43], we would also have expected lower adiponectin levels in obese children than in controls, but merely observed a trend (p00.09).…”

Section: Discussioncontrasting

confidence: 65%

“…Earlier studies on small sets of circulating mediators showed greater levels of inflammatory mediators, including high-sensitivity C-reactive protein (hsCRP), leptin, IL-6 and IL-8, together with decreased levels of the insulin-sensitising adipokine, adiponectin, and higher leucocyte numbers in obese children than in lean controls [15][16][17][18]. These studies indicated that low-grade systemic inflammation is already present during childhood obesity.…”

Section: Introductionmentioning

confidence: 90%

Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes

et al. 2012

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Aims/hypothesis In adults, circulating inflammatory mediators and activated CD14 ++ monocytes link obesity to its metabolic and cardiovascular complications. However, it is largely unknown whether these inflammatory changes already occur in childhood obesity. To survey inflammatory changes during the early stages of obesity, we performed a comprehensive analysis of circulating inflammatory mediators, monocyte populations and their function in childhood obesity. Methods In lean and obese children aged 6 to 16 years (n0 96), 35 circulating inflammatory mediators including adipokines were measured. Hierarchical cluster analysis of the inflammatory mediator profiles was performed to investigate associations between inflammatory mediator clusters and clinical variables. Whole-blood monocyte phenotyping and functional testing with the toll-like receptor 4 ligand, lipopolysaccharide, were also executed. Results First, next to leptin, the circulating mediators chemerin, tissue inhibitor of metalloproteinase 1, EGF and TNF receptor 2 were identified as novel inflammatory mediators that are increased in childhood obesity. Second, cluster analysis of the circulating mediators distinguished two obesity clusters, two leanness clusters and one mixed cluster. All clusters showed distinct inflammatory mediator profiles, together with differences in insulin sensitivity and other clinical variables. Third, childhood obesity was associated with increased CD14 ++ monocyte numbers and an activated phenotype of the CD14 ++ monocyte subsets. Conclusions/interpretation Inflammatory mediator clusters were associated with insulin resistance in obese and lean ++ monocyte subsets, which is associated with increased development of atherosclerosis in obese adults, was also readily detected in obese children. Our results indicate that inflammatory mechanisms linking obesity to its metabolic and cardiovascular complications are already activated in childhood obesity.

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“…Other inflammatory markers, such as IL-1α, IL-2, IL-4, IL-8, IL-10, vascular endothelial growth factor (VEGF), interferon-γ (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), and epidermal growth factor have been less investigated [7,12]. Glowinska and Urban [13] did not find differences in IL-8, IL-10, and MCP-1 levels between 14- to 17-year-old obese and normal-weight adolescents.…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum IL-6, IL-8, MCP-1, CRP, and IFN-γ Levels in 10- to 11-Year-Old Boys with Increased BMI

Utsal

Tillmann

Zilmer³

et al. 2012

Horm Res Paediatr

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Background/Aims: Many inflammation parameters are associated with obesity, but few comparable data are found in youth. This study aims to characterize the differences in serum levels of 13 biochemical inflammatory markers between boys with increased BMI and boys with normal BMI, and examine the relationships between inflammation markers, skinfold thicknesses, and body composition. Participants/Methods: The participants were 38 boys (BMI above 85th percentile) and 38 boys (normal BMI) at the age of 10–11 years. Measurements included BMI, 9 skinfold thicknesses, waist and hip circumferences, and total body and trunk fat mass and percentage as indices of obesity, fasting insulin, glucose, and serum concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-γ, TNF-α, IL-1α, IL-1β, monocyte chemoattractant protein-1 (MCP-1), epidermal growth factor, and CRP. Results: Overweight boys (OWB) were taller and more frequently in puberty than normal-weight boys (NWB). Skinfold thicknesses and body composition parameters were higher in OWB. They had significantly higher serum IL-6, IL-8, IFN-γ, MCP-1, and CRP values compared to NWB. Conclusions: Six of 13 measured biochemical markers were significantly increased in OWB, indicating that many low-grade inflammatory processes are already involved in the development of obesity in childhood.

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IL-6, IL-8 and IL-10 Levels in Healthy Weight and Overweight Children

Cited by 62 publications

References 95 publications

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes

Elevated Serum IL-6, IL-8, MCP-1, CRP, and IFN-γ Levels in 10- to 11-Year-Old Boys with Increased BMI

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