2017
DOI: 10.1515/rrlm-2016-0044
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IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Abstract: Objectives: The goal of the study was to investigate the correlations between the interleukin-6 IL-6 -174 G/C and IL-6 -572 G/C gene polymorphisms and sepsis risk and severity in adult ICU patients. Materials and Methods: We prospectively assessed 107 septic patients and divided them into two subgroups: organ dysfunction-free sepsis subgroup S (n=60) and septic shock subgroup SS (n=47). A control group of 96 healthy individuals was included. Both patients and controls underwent

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Cited by 13 publications
(14 citation statements)
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“…The severity scores in this reference unit are significantly above the levels in other ICUs. Consequently, this also leads to much higher mortality rates, which is also reflected in previous sepsis studies [50,76,77].…”
Section: Discussionmentioning
confidence: 62%
See 1 more Smart Citation
“…The severity scores in this reference unit are significantly above the levels in other ICUs. Consequently, this also leads to much higher mortality rates, which is also reflected in previous sepsis studies [50,76,77].…”
Section: Discussionmentioning
confidence: 62%
“…The study was designed as a non-interventional prospective cohort study. The patients enrolled during the first 10 months of the study had been included in a previous report discussing interleukin IL-6 genetic variability in sepsis [50]. The previously reported inclusion and exclusion criteria were applied.…”
Section: Study Populationmentioning
confidence: 99%
“…Based on their inflammatory activity, cytokines are divided into pro‐inflammatory (IL‐6, IL‐17, IL‐18, TNF‐α, interferon gamma [IFN‐γ], etc) and anti‐inflammatory (Il‐4, IL‐10, IL‐13, etc) ones, whereas several cytokines have a dual role (IL‐10, IL‐22, TGF‐β1) . Interleukin‐10, an anti‐inflammatory cytokine, has dual functions, being both immune‐suppressive (tumor‐inhibiting) and immune‐stimulating (tumor‐promoting), and may, therefore, influence tumor susceptibility and development.…”
Section: Introductionmentioning
confidence: 99%
“…3,4 Chronic inflammation is associated with the release of various mediators (pro-inflammatory and oncogenic ones), such as reactive nitrogen oxygen species, inflammatory cytokines (IL-1β, IL-2, IL-6, and tumor necrosis factor alpha [TNF-α]), growth factors, and chemokines. 4 Based on their inflammatory activity, cytokines are divided into pro-inflammatory (IL-6, IL-17, IL-18, TNF-α, interferon gamma [IFN-γ], etc) 5 and anti-inflammatory (Il-4, IL-10, IL-13, etc) ones, whereas several cytokines have a dual role (IL-10, IL-22, TGF-β1). 6 Interleukin-10, an anti-inflammatory cytokine, has dual functions, being both immune-suppressive (tumor-inhibiting) and immune-stimulating (tumor-promoting), and may, therefore, influence tumor susceptibility and development.…”
Section: Introductionmentioning
confidence: 99%
“…IL-6 cytokine seems to be a promising biomarker in sepsis since it is involved in triggering and modulating the inflammatory response to microbial injury. Its fast dynamics, with a rapid increase of IL-6 levels in the early stages of sepsis are important features which make it a good biomarker for sepsis; surprisingly it is not routinely used [12].…”
mentioning
confidence: 99%