IL-6, DHEA and the ageing process

James, Keith; Premchand, N; Skibinska, Anna; Skibiński, Grzegorz; Nicol, M; Mason, Jonathan H.

doi:10.1016/s0047-6374(96)01807-6

Cited by 46 publications

(21 citation statements)

References 23 publications

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“…In contrast, the more recently reported rise in IL-6 secretion by lymphocytes from aged individuals, a TH2 function, is probably an ageing phenomenon. IL-6 secretion is increased in aged individuals (Daynes et al 1993;Erschler et al 1993;James et al 1997), even in the very-carefully-selected healthy elderly . It has been reported recently that this phenomenon starts in middle age (between age 36 and 59 years; Mysliwska et al 1998), and is more pronounced in the very old (nonagenarians) than in the young old (Table 3).…”

Section: T-cell Functionsmentioning

confidence: 99%

Nutrition and immunity in the elderly

1999

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Immune function declines with age, leading to increased infection and cancer rates in aged individuals. In fact, recent progress in the study of immune ageing has introduced the idea that rather than a general decline in the functions of the immune system with age, immune ageing is mainly characterized by a progressive appearance of immune dysregulation throughout life. Changes appear earlier in life for cell-mediated immunity than for humoral immunity. Thus, agerelated modifications in cell-mediated immunity, i.e. changes in naive : memory T-cells, mature : immature T-cells, T-helper 1 : T-helper 2 cells are more important in the elderly than changes in humoral immunity, i.e. CD5 : CD5+ cells or length of antibody responses. Such evolution of the immune system has been linked to declining thymus function and to accumulative antigenic influence over the lifespan. In contrast, innate immunity (macrophage functions) is preserved or even increased during the ageing process. This finding shows that the 'primitive' immune system is less affected by the ageing process than the sophisticated specific immune system. The present review focuses on innate and cell-mediated immune changes with ageing. It provides evidence that primary changes (intrinsic modifications in the immune system) and secondary changes (resulting from environmental influences during the lifespan) exert different influences on the immune system. Primary changes, occurring in healthy individuals, seem less important nowadays than they were considered to be previously. For example, interleukin 2 secretion in some very healthy aged individuals is comparable with that in younger adults. Primary immune changes may not explain the increased incidence and severity of infections observed in the elderly population. Secondary immunological changes are far more frequent and are certainly responsible for most of the immune modifications observed in the elderly population. Environmental factors leading to secondary immune dysfunctions include not only antigenic influence, which is a reflection of diseases experienced over the lifespan, but also many other factors such as drug intake, physical activity and diet; factors for which important changes occur in the elderly population. Nutritional factors play a major role in the immune responses of aged individuals and the present review shows that nutritional influences on immune responses are of great consequence in aged individuals, even in the very healthy elderly.

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Section: T-cell Functionsmentioning

confidence: 99%

Nutrition and immunity in the elderly

1999

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“…One measured IL-6 byan ELISA [49], while the other used bioassay [50]. Two other studies found no difference in IL-6 levels in plasma by ELISA [51] or in sera by bioassay [52].…”

Section: Il-6mentioning

confidence: 99%

Effect of age on cytokine production in humans

Bernstein

Murasko

1998

AGE

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Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFNγ) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 studies in humans suggests that age-associated changes in cytokine production are not consistent.

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“…The administration of DHEAS to aging animals elicits a number of biologic changes that are mediated through a process involving PPAR␣ activation with reversal of the dysregulated cytokines, particularly IL-6 (29). In humans, James et al (31) and Straub et al (23) have provided evidence that serum levels of IL-6 increase with age and that serum DHEAS levels are negatively correlated with serum IL-6 concentrations in both aging men and women. The maximal effective dose of DHEA is in the range for immunomodulation (23).…”

mentioning

confidence: 99%

Dehydroepiandrosterone sulfate and longevity: New clues for an old friend

Yen

2001

Proc. Natl. Acad. Sci. U.S.A.

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IL-6, DHEA and the ageing process

Cited by 46 publications

References 23 publications

Nutrition and immunity in the elderly

Nutrition and immunity in the elderly

Effect of age on cytokine production in humans

Dehydroepiandrosterone sulfate and longevity: New clues for an old friend

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