IL-6 and IL-10 Promoter Gene Polymorphisms in Psoriasis Vulgaris

Abstract

Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide polymorphisms and susceptibility to psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers was investigated. IL-6 promoter gene single nucleotide polymorphisms in position -174, and IL-10 single nucleotide polymorphisms in positions -1082, -819 and -592 were evaluated by polymerase chain reaction using sequence-specific primers. No significant differences were found in the polymorphisms of IL-6 and IL-10 promoter genes between patients with psoriasis and healthy controls.

Interleukin-6 and Interleukin-10 Gene Promoter Polymorphisms and Risk of Endemic Burkitt Lymphoma

“…Only -1082 seems to affect cytokine levels, with the A and G alleles associated with lower and higher levels, respectively. 25 Specific haplotypes of these three SNPs are also associated with IL-10 production levels; for example, the IL-10 -1082G, -819C, -592C (GCC) haplotype of the promoter region is associated with high expression, whereas the ATA haplotype is associated with low IL-10 levels in children. 26 Given these associations, we hypothesized that polymorphisms in the IL-6 and IL-10 promoter, which influence their respective production, may predispose children to eBL as they cope with malaria and EBV coinfections.…”

Investigation of cytokine gene polymorphisms in patients with psoriasis vulgaris

“…İL-6, akut enflamatuvar reaksiyon geliştirebildiği gibi kronik fazda lenfositlerin ve epidermiste keratinositlerin aktivasyonunu da sağlar. Yapılan çalışmalarda İL-6 ile hastalık arasında anlamlı bir ilişki gösterilmemiştir 2,15 . Çalışmamızda da literatürlerle uyumlu olarak İL-6 gen polimorfizmi ile hastalık, başlangıç yaşı, artrit gelişimi ve hastalığın şiddeti açısından anlamlı bir fark bulunamadı.…”

“…İL-10, proenflamatuvar sitokinlerin üretimini baskılayarak enflamasyonu kontrol eder. İL-10 gen polimorfizmleri ile ilişkili yapılan çalışmalarda bir grup araştırmacı hastalık ile ilişki saptanmazken 2,6 , diğer araştırmacılardan Craven ve ark. 16 İL-10 -1082 GA genotipini geç başlangıçlı hasta grubunda anlamlı derecede yüksek bulmuşlardır.…”

Genetic Factors in Immunopathogenesis of Psoriasis and Psoriatic Arthritis

“…У поля-ков ассоциации между полиморфизмом в пози-ции G-174C гена IL6 с псориазом не выявлено [9]. Показана роль данного генетического маркера в ответе больных ПС на анти-TNF терапию -так, у носителей аллельного варианта -174*С эффект на терапию слабее, чем у носителей варианта -174*G [15].…”

“…Результаты мета-анализа трех полиморфизмов промоторного региона гена IL10 (-1082 G/A, -592 C/A, -819 C/T) показали ассоциацию полимор-физма G-1082A с восприимчивостью азиатов, но не европеоидов, к развитию псориаза, что ука-зывает на то, что данный маркер имеет специ-фический этнический эффект [32]. Отсутствие ассоциации трех указанных полиморфизмов гена IL10 с псориазом было показано также на других европеоидных популяциях -поляках, эстонцах [9,29]. Генотипы IL10 -1082GG и TNFА -308GG достоверно чаще встречались у больных псориа-зом египтян, причем их частота была выше у боль-ных с более тяжелым течением заболевания [55].…”