IL-6 and IL-10 gene polymorphisms and cirrhosis of liver risk from a comprehensive analysis

Abstract

Background Different inflammatory and immune cytokines play a key role in the development of cirrhosis of liver (CL). To investigate the association between interleukin-6,10 (IL-6,10) genes polymorphisms and CL risk through comparison of the allele and genotype distribution frequencies by meta-analysis. Methods A literature search covered with the PubMed, Embase, Cochrane Library, Web of Science, Google Scholar, SinoMed (CNKI and Wanfang) through 20th April, 2021. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. Results After a comprehensive search, three common polymorphisms (rs1800872, rs1800871, rs1800896) in IL-10 gene were selected, and three common polymorphisms (rs1800795, rs1800796, rs1800797) in IL-6 gene were also identified. The important finding was that IL-10 rs1800872 was a risk factor for CL development. For example, there has a significantly increased relationship between rs1800872 polymorphism and CL both in the whole group (OR: 1.30, 95%CI: 1.01–1.67 in heterozygote model), Asian population (OR: 1.40, 95%CI: 1.03–1.88 in heterozygote model) and hospital-based source of control (OR: 1.40, 95%CI: 1.01–1.96 in dominant model). In addition, significant association was found between rs1800896 and primary biliary cirrhosis subtype disease (OR: 1.30, 95%CI: 1.01–1.68 in allelic contrast model). No association was observed in all three polymorphisms in IL-6 gene. Conclusion Our present study suggests that the IL-10 rs1800872 and rs1800896 polymorphisms is potentially associated with the risk of CL susceptibility.

The TNF-α rs361525 and IFN-γ rs2430561 polymorphisms are associated with liver cirrhosis risk: a comprehensive meta-analysis

“…The hub gene TNFRSF1A may offer value as a marker of PBC (58), and one GWAS study of 1,840 cases and 5,163 controls identified the TNFRSF1A rs1800693 SNP as a PBC-related risk factor (OR=1.23, 95%CI=1. 14 STRING network diagrams depicting interactions between human TNF-a or IFN-g and other genes. (A, B).…”

“…Growth factors and cytokines such as members of the interferon (IFN) and tumor necrosis factor (TNF) family are vital components of host immune activity that can shape viral infection-related processes and the subsequent development of fibrosis (12, 13). In a prior study, our group conducted a meta-analysis examining the relationship between mutations in the IL-6 and IL-10 genes (rs1800871, rs1800872, rs1800795, rs1800796, rs1800797, rs1800896) and LC risk, ultimately identifying the IL-10 -592 and -1082 polymorphisms as being closely linked to LC susceptibility (14). Other reports have specifically focused on links between IFN-g and TNF-a genes polymorphisms and cirrhotic disease (15).…”

Gene polymorphisms of inflammatory factors in liver cirrhosis

“…IL-6, a primary immunomodulatory cytokine, has been shown related to liver cirrhosis in a few studies. Zheng et al (2021) identified three polymorphisms in IL-6 gene and perform a meta-analysis to explore their association with liver cirrhosis. Five polymorphisms (rs1474347, rs10499563, rs2069837, rs1800795, rs1800796) in IL-6 gene were also identified in our systematic review.…”

“…So far, several common inflammatory factors gene polymorphisms in liver cirrhosis have been investigated by meta-analysis ( Chen et al, 2011 ; Guo et al, 2015 ; Guo et al, 2018 ; Zheng et al, 2021 ; Liu and Yang, 2022 ). However, to our knowledge, there has not been a systematic review and meta-analysis that has comprehensively assessed the association of inflammatory factors gene polymorphisms with liver cirrhosis.…”

High plasma interleukin‐6 level, but not IL‐6 gene variants, as a predictive marker for the development of hepatocellular carcinoma in a Moroccan population

“…Minghui et al. defined that the rs1800896 polymorphism may be linked to the risk of susceptibility to liver cirrhosis (Zheng et al., 2021).…”