IL-5 in follicular fluid as a negative predictor of the intracytoplasmic sperm injection outcome

Alhilali, Miaad Jabbar Sahib; Parham, Abbas; Attaranzadeh, Armin; Amirian, Malihe; Azizzadeh, Mohammad

doi:10.1016/j.cyto.2018.07.016

Cited by 13 publications

(7 citation statements)

References 40 publications

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“…Both IL10 and IL18 were predictive of oocyte maturation at the univariate level, and following model building only IL10 remained predictive. Both IL10 and IL18 have been previously reported to be positively correlated with follicular maturation and ovarian response to stimulation (Sarapik et al, 2012;Nuñez-Calonge et al, 2016;Alhilali et al, 2019). In the current study, following ROC analysis, IL10 displayed robust sensitivity and specificity.…”

Section: Discussionsupporting

confidence: 49%

The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes

Wyse

Weizman

Defer

et al. 2021

Reproductive BioMedicine Online

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Section: Discussionsupporting

confidence: 49%

The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes

Wyse

Weizman

Defer

et al. 2021

Reproductive BioMedicine Online

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“…The present study was part of a larger research project regarding the association of some folicullar fluid cytokines with intracytoplasmic sperm injection outcome (15). Based on the inclusion criteria, from the 80 patients of original project, sixty couples suffering from female infertility who were undergoing assisted reproduction treatment using ICSI in Milad Infertility Center, Mashhad University of Medical Sciences, Iran entered the study.…”

Section: Experimental Modelsmentioning

confidence: 99%

“…The previously described ovarian superovulation protocols by Alhilali et al (2019) were used in this study [15]. Briefly, ovarian superovulation was performed by daily administration of recombinant FSH (Gonal-F; "Merck" Serono, Germany) with agonist long beginning at the mid-luteal phase (day 21) of the previous cycle and continued to the day of hCG injection, while the antagonist protocol was achieved using (Cetrotide; Merk Serono, Germany) daily administration at the midfollicular phase after the size of follicles reached 12 mm at least.…”

Section: Experimental Modelsmentioning

confidence: 99%

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Prognostic role of follicular fluid tumor necrosis factor alpha in the risk of early ovarian hyperstimulation syndrome

Alhilali

Parham

Attaranzadeh

et al. 2020

BMC Pregnancy Childbirth

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Background Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic condition characterized by capillary hyperpermeability which can be predicted by preovulatory ovarian responses such as number of follicles. A variety of cytokines are thought to be involved in pathophysiology of this syndrome. Methods A prospective cohort study invloving sixty intracytoplasmic sperm injection (ICSI) patients. On the day of hCG injection, we explored the threshold of larger follicles ≥11 mm diameter with a count of ≥18 follicles for the high-risk moderate-to-severe OHSS and 13–18 follicles for the low-risk moderate-to-severe OHSS. Whereas larger follicles count of less than 13 were classified as normoresponders. Pooled follicular fluid (FF) samples of each patient were collected on the day of oocyte retrieval. Magnetic multiplex immunoassay was explored to measure the concentrations of some intrafollicular cytokines including: GM-CSF, INF-γ, TNF-α, IL-10, CXCL8/IL-8, IL-6, IL-5, IL-4, IL-2, and IL-1β. All sixty patients underwent controlled ovarian hyperstimulation (COH) with either GnRH agonist or antagonist protocols. Results Intrafollicular TNF-α concentration was significantly different (p < 0.05) in the high-risk moderate-to-severe OHSS patients compared to low-risk moderate-to-severe OHSS patients and normoresponders. TNF-α in FF had a negative correlation with the chance of high-risk moderate-to-severe OHSS. The differences in the risk of OHSS between patients who received GnRH agonist or antagonist were not significant (p > 0.05). Conclusions In accordance to the negative correlation of TNF-α and high risk of early OHSS, we did not expect TNF-α to play a role in increasing vascular permeability in ovarian tissues. In addition, the risk of early moderate-to-severe OHSS was not affected by different GnRH superovulation protocols.

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“…[ 20 ] In addition, some studies have suggested that IL-6 does not affect the clinical rate of pregnancy, as well as the quality of oocytes. [ 21 – 23 ]…”

Section: Introductionmentioning

confidence: 99%

IL-6 of follicular fluid and outcome of in vitro fertilization

et al. 2022

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The quality of an oocyte is influenced by its microenvironment, which includes cumulus cells and follicular fluid, as well as cells of the immune system and their products. The ovarian interleukins, which are secreted by the granulosa cells and other immune cells within the ovaries and follicles, regulate various functions between the cells. IL-6 is a cytokine that is present in the follicular fluid and may affect the quality of oocytes. There are some inconsistencies in the literature regarding the concentration of interleukin 6 in the follicular fluid. The main objective of this study was to examine whether the concentration of interleukin 6 in the follicular fluid affects the outcome of IVF. This study involved 83 patients who underwent IVF. Follicular fluid was used as the biological material for the analysis. Examination of the obtained follicular fluid and collection of oocytes under a stereomicroscope was performed in the embryological laboratory. The concentration of IL-6 in the follicular fluid was analyzed. IVF and ICSI methods were used as the fertilization methods. Pregnancy was confirmed by the positive serum β-hCG level. The software package SPSS 20 was used for statistical data processing. Analysis of the follicular fluid samples showed a correlation between the concentration of IL-6 in the follicular fluid and the outcome of IVF. The concentration of IL-6 in the follicular fluid was higher in patients with confirmed pregnancy (9.55 ± 7.47 ng/ml). Based on our results, we conclude that the concentration of IL-6 affects the outcome of IVF. If the range of IL-6 concentration is between 3,67 ng/ml and 10 ng/ml, we can expect good IVF outcome with vital pregnancy.

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IL-5 in follicular fluid as a negative predictor of the intracytoplasmic sperm injection outcome

Cited by 13 publications

References 40 publications

The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes

The follicular fluid adipocytokine milieu could serve as a prediction tool for fertility treatment outcomes

Prognostic role of follicular fluid tumor necrosis factor alpha in the risk of early ovarian hyperstimulation syndrome

IL-6 of follicular fluid and outcome of in vitro fertilization

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