IL‐5, IL‐8 and tgf‐beta expressions in chronic rhinosinusitis patients with nasal polyps and their correlation to tissue's cellularity and disease relapsing

Anselmo‐Lima, Wilma Terezinha; Gallego, Aline J.; Cavallari, Fransérgio E. M.; Küpper, Daniel; Milanezi, Cristiane M.; Silva, João; Oliveira, Siomara Bambirra; Faria, Franscesca M; Tamashiro, Edwin; Valera, Fabiana

doi:10.1186/2045-7022-3-s2-p14

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“…Cascade from the cytokine will increase the infiltration of inflammatory cells, especially eosinophils. Then eosinophils will migrate and encourage the inflammatory process causing stromal fibrosis, epithelial damage, increased edema in the interstitial tissue and increased production of extracellular matrix [13], [14]. Bachert et al (2010) examined the levels of several cytokines and chemokines in nasal polyps and normal turbinate individual.…”

Section: Fig 4 the Correlation Between Il-5 Il8 And Il-17a Expresmentioning

confidence: 99%

Correlation of Inflammation Mediator Profile Expression Between Tissues and Mucosal in Chronic Rhinosinusitis with Nasal Polyp

Huriyati¹

2019

Proceedings of the Proceedings of the 1st EAI International Conference on Medical and Health Research, ICoMHER November 13-14th

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There are differences inflammatory patterns in Chronic Rhinosinusitis with Nasal Polyp (CRSwNP) between Caucasians and Asians. One of the most convenient and non-invasive examination tools to find out the inflammatory pattern of CRSwNP is such as mucosal brushing of the polyp. This research investigated the correlation of expression IL-5, IL-8, and IL-17A between the tissue and mucosal polyp.A cross-sectional comparative study involving 15 samples of mucosal brushing and 15 of polyp tissues were performed. We measured IL-5, IL-8, and IL-17A level of mucosal brushing with the Enzyme-Linked Immunosorbent Assay (ELISA) and polyp tissues with immunohistochemistry (IHC) examination. The mean expression of IL-5, IL-8, and IL-17A by IHC 16.969), 88.20% (16.781) and ELISA 16.969). There was no significant relationship between tissue (IHC) and mucosa (ELISA) (p> 0.05), but in IL-5 expression there was a moderate positive correlation (0.41

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Section: Fig 4 the Correlation Between Il-5 Il8 And Il-17a Expresmentioning

confidence: 99%

Correlation of Inflammation Mediator Profile Expression Between Tissues and Mucosal in Chronic Rhinosinusitis with Nasal Polyp

Huriyati¹

2019

Proceedings of the Proceedings of the 1st EAI International Conference on Medical and Health Research, ICoMHER November 13-14th

View full text Add to dashboard Cite

show abstract

IL‐5, IL‐8 and tgf‐beta expressions in chronic rhinosinusitis patients with nasal polyps and their correlation to tissue's cellularity and disease relapsing

Cited by 1 publication

References 0 publications

Correlation of Inflammation Mediator Profile Expression Between Tissues and Mucosal in Chronic Rhinosinusitis with Nasal Polyp

Correlation of Inflammation Mediator Profile Expression Between Tissues and Mucosal in Chronic Rhinosinusitis with Nasal Polyp

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