IL-5 Augments Macrophage Function In Polymicrobial Sepsis

Linch, Stefanie N.; Kelly, Ann Marie; Danielson, Erin T.; Gold, Jeffrey A.

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1802

A52. Pneumonia: Host Defense Mechanisms to Infectious Challenge 2010

DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1802

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IL-5 Augments Macrophage Function In Polymicrobial Sepsis

Stefanie N. Linch

Ann Marie Kelly

Erin T. Danielson

et al.

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2012

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“…Moreover, the limited and specific expression of the IL-5 receptor on these cells provides a targeted means to augment myeloid function in sepsis. Some of these results have been reported in the form of an abstract (26,27).…”

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confidence: 92%

Interleukin 5 Is Protective during Sepsis in an Eosinophil-Independent Manner

Linch

Danielson

Kelly

et al. 2012

Am J Respir Crit Care Med

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Rationale: The immune response in sepsis is characterized by overt immune dysfunction. Studies indicate immunostimulation represents a viable therapy for patients. One study suggests a potentially protective role for interleukin 5 (IL-5) in sepsis; however, the loss of eosinophils in this disease presents a paradox. Objectives: To assess the protective and eosinophil-independent effects of IL-5 in sepsis. Methods: We assessed the effects of IL-5 administration on survival, bacterial burden, and cytokine production after polymicrobial sepsis. In addition, we examined the effects on macrophage phagocytosis and survival using fluorescence microscopy and flow cytometry. Measurements and Main Results: Loss of IL-5 increased mortality and tissue damage in the lung, IL-6 and IL-10 production, and bacterial burden during sepsis. Therapeutic administration of IL-5 improved mortality in sepsis. Interestingly, IL-5 administration resulted in neutrophil recruitment in vivo. IL-5 overexpression in the absence of eosinophils resulted in decreased mortality from sepsis and increased circulating neutrophils and monocytes, suggesting their importance in the protective effects of IL-5. Furthermore, novel data demonstrate IL-5 receptor expression on neutrophils and monocytes in sepsis. IL-5 augmented cytokine secretion, activation, phagocytosis, and survival of macrophages. Importantly, macrophage depletion before the onset of sepsis eliminated IL-5-mediated protection. The protective effects of IL-5 were confirmed in humans, where IL-5 levels were elevated in patients with sepsis. Moreover, neutrophils and monocytes from patients expressed the IL-5 receptor. Conclusions: Taken together, these data support a novel role for IL-5 on noneosinophilic myeloid populations, and suggest treatment with IL-5 may be a viable therapy for sepsis.

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mentioning

confidence: 92%

Interleukin 5 Is Protective during Sepsis in an Eosinophil-Independent Manner

Linch

Danielson

Kelly

et al. 2012

Am J Respir Crit Care Med

Self Cite

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IL-5 Augments Macrophage Function In Polymicrobial Sepsis

Cited by 1 publication

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Interleukin 5 Is Protective during Sepsis in an Eosinophil-Independent Manner

Interleukin 5 Is Protective during Sepsis in an Eosinophil-Independent Manner

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