IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma

Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma

“…TXA 2 receptor (TP) genetic polymorphisms have been reported to be associated with asthma, the severity of asthma, specific IgE synthesis, and atopic dermatitis [35][36][37][38]. Previously, we reported the result of an association analysis of two TBXA2R SNPs (795T > C and 924T > C), which were selected on the basis of National center for Biotechnology Information Prostanoid receptors and aspirin-intolerant asthma Kim et al 301 database information, and found a significant association of 795T > C with AIA, which may reflect a mechanism for increasing the bronchoconstrictor response to aspirin [19].…”

TBXA2R gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma

“…The baseline characteristics of the subjects are shown in Table 1. No differences among the three groups in mean age and sex were found, but there were significant differences in total serum IgE levels, total eosinophil counts, eosinophil fraction, forced expiratory volume in 1 s (FEV 1 ), forced expiratory rates at 25-75% of vital capacity (FEF 25 À 75% ), PC 20 , and maximum percent fall in FEV 1 after exercise among the three groups (P o 0.01) ( Table 1).…”

“…FEV 1 was measured using a spirometer (Microspiro HI-298). Lung function was measured immediately after exercise, as well as after 5,10,15,20,25,30,45, and 60 min. All spirometric techniques achieved ATS acceptability and reproducibility criteria [18].…”

Prostacyclin receptor/thromboxane receptor interactions and cellular responses in human atherothrombotic disease

“…Homozygous 795 T/T displays gene-gene interaction with interleukin-4 receptor α polymorphism (I 50 V) [53]. The C 924 T polymorphism is associated with aspirin resistance [54], bronchial asthma [55], and atopic asthma [56]. Interestingly, the 924 T polymorphism also demonstrates interleukin gene-gene interactions, with an interleukin-5 polymorphism (T 746 C) reducing pulmonary function [56].…”

“…The C 924 T polymorphism is associated with aspirin resistance [54], bronchial asthma [55], and atopic asthma [56]. Interestingly, the 924 T polymorphism also demonstrates interleukin gene-gene interactions, with an interleukin-5 polymorphism (T 746 C) reducing pulmonary function [56]. PGI 2 and TxA 2 Ligands for Therapy Prostanoid signaling is inherently complicated, as chemical similarity of prostanoid ligands allows promiscuity among affected receptors.…”