IL-4 shaping glutamatergic synapse like structures for more mature iPSC derived neuron phenotypes
David Zimmermann,
Clemens L. Schöpf,
Georg Kern
et al.
Abstract:The prototypical pleiotropic anti-inflammatory cytokine IL-4 not only acts on immune cells but also has important roles in the nervous system mediating antinociception and neuroregeneration. Therefore, we explored the expression of IL-4, its receptors IL4RA and IL13RA1 and downstream signaling components together with morphological and functional assays as well as transcriptomic profiling in human nociceptors differentiating from induced pluripotent stem cells (iNocs).IL-4 induced de novo formation of synaptic… Show more
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