IL-33 promotes sciatic nerve regeneration in mice by modulating macrophage polarization

Smail, Shukur Wasman; Abdulqadir, Shang Ziyad; Khudhur, Zhikal Omar; Ishaq, Sonia Elia; Ahmed, Aminul I.; Ghayour, Mohammad Bagher; Abdolmaleki, Arash

doi:10.1016/j.intimp.2023.110711

Cited by 3 publications

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this purpose, to this end, the sham surgery group should be compared to the healthy controls to determine whether the surgical procedures (except nerve injury) could cause a change in the normal parameters. Sham surgery is widely used in surgical research, including studies on sciatic nerve regeneration [32][33][34]. Because no significant difference was observed between the sham surgery and healthy control groups, the data from the healthy groups were not shown to simplify the graphs.…”

Section: Animals and Experimental Groupsmentioning

confidence: 99%

Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats

Omar Khudhur,

Ziyad Abdulqadir,

Faqiyazdin Ahmed Mzury

et al. 2023

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

BackgroundEpothilone B (EpoB) is a microtubule‐stabilizing agent with neuroprotective properties.ObjectivesThis study examines the regenerative properties of ANA supplemented with EpoB on a sciatic nerve deficit in male Wistar rats.MethodsFor this purpose, the 10 mm nerve gap was filled with acellular nerve allografts (ANAs) containing EpoB at 0.1, 1, and 10 nM concentrations. The sensorimotor recovery was evaluated up to 16 weeks after the operation. Real‐time PCR, histomorphometry analysis, and electrophysiological evaluation were also used to evaluate the process of nerve regeneration.ResultsANA/EpoB (0.1 nM) significantly improved sensorimotor recovery in rats compared to ANA, ANA/EpoB (1 nM), and ANA/EpoB (10 nM) groups. This led to reduced muscle atrophy, improved sciatic functional index, and thermal paw withdrawal reflex latency, indicating nerve regeneration and target organ reinnervation. The electrophysiological and histomorphometry findings also confirmed the ANA/EpoB regenerative properties (0.1 nM). EpoB only enhanced ANA regenerative properties at 0.1 nM, with no therapeutic effects at higher concentrations.ConclusionTotally, we concluded that ANA loaded with 0.1 nM EpoB can effectively reconstruct the transected sciatic nerve in rats, likely by enhancing axonal sprouting and extension.

show abstract

Section: Animals and Experimental Groupsmentioning

confidence: 99%