2011
DOI: 10.1038/onc.2011.52
|View full text |Cite
|
Sign up to set email alerts
|

IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals

Abstract: Several studies have shown physiological functions of interleukin (IL)-32, a novel cytokine. However, the role of IL-32 in cancer development has not been reported. In this study, we showed that IL-32γ inhibited tumor growth in IL-32γ-overexpressing transgenic mice inoculated with melanoma as well as colon tumor growth in xenograft nude mice inoculated with IL-32γ-transfected colon cancer cells (SW620). The inhibitory effect of IL-32γ on tumor growth was associated with the inhibition of constitutive activated… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

10
100
1

Year Published

2011
2011
2020
2020

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 89 publications
(113 citation statements)
references
References 52 publications
10
100
1
Order By: Relevance
“…This in vitro study revealed that the inhibitory effect of IL-32 γ was due to blockade of the NK-κB and STAT3 pathways involved in tumor cell growth. Moreover, IL-32 γ transgenic mice models showed a decreased expression of antiapoptotic, cell proliferation, and tumor-producing genes such as cleaved caspase-3 and -9, bax, cyclin D, COX-2, and iNOS, whereas the expression of their target apoptotic genes such as BCL-2 and X-chromosome inhibitor of apoptosis protein was significantly increased (39). The findings of the two recent studies indicate that IL-32 has anticancer effects in human malignancies.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This in vitro study revealed that the inhibitory effect of IL-32 γ was due to blockade of the NK-κB and STAT3 pathways involved in tumor cell growth. Moreover, IL-32 γ transgenic mice models showed a decreased expression of antiapoptotic, cell proliferation, and tumor-producing genes such as cleaved caspase-3 and -9, bax, cyclin D, COX-2, and iNOS, whereas the expression of their target apoptotic genes such as BCL-2 and X-chromosome inhibitor of apoptosis protein was significantly increased (39). The findings of the two recent studies indicate that IL-32 has anticancer effects in human malignancies.…”
Section: Discussionmentioning
confidence: 99%
“…However, the overexpression of IL-32 inhibited the HPV-16 E7-mediated COX-2 activation pathway and, ultimately, exhibited anti-oncogenic effects (22). In the most recent study on IL-32 and human cancer, Oh et al studied the expression of IL-32 in colon cancer and malignant melanoma cells using xenograft nude mice inoculated with IL-32 γ-transfected malignant cells (39). They observed the inhibitory effect of IL-32 γ on the growth of both malignant cell types.…”
Section: Discussionmentioning
confidence: 99%
“…Their gastric mucosa expresses higher levels of IL-32, as well as levels in sera of same patients. Opposite to these findings, there are several reports about inhibitory effects of IL-32 on cancer cell growth, especially via the NF-κB and STAT3 signaling (29). IL-32θ inhibited epithelial-mesenchymal transition (EMT), resulting in the suppression of migratory and invasive capabilities of HT29 colon cancer cells (74).…”
Section: Role In Cancer Biologymentioning
confidence: 99%
“…Earlier investigations concluded that IL-32 downstream signaling involved multiple pathways -NF-κB and p38 MAPK pathways, Erk1/2 and PI3 K/Akt pathways, and IL-32-exposed human macrophage-like THP-1 cells resulted in the phosphorylation of p300 and DAPK-1 (23,10,28,29). But until today it was not clear whether this cytokine acts on intra-or extracellular level.…”
Section: Il-32 Signaling and Role In Cell Biologymentioning
confidence: 99%
“…Furthermore, the role of IL-32 in the production of regulatory cytokines has been described: IL-32β interacts with PKCδ and C/EBPα, which results in the production of IL-10 [16], and IL-32γ is correlated with enhanced production of proinflammatory cytokines, such as IL-1β and IL-6 [17]. IL-32γ is also implicated in HIV immunosuppression [18] and tumoral growth inhibition [19]. The interaction between IL-32δ and IL-32β isoforms inhibits IL-10 production by IL-32β [20], which suggests that other interactions between IL-32 isoforms may explain their multifunctional role [21].…”
Section: Introductionmentioning
confidence: 99%