IL-27 signalling promotes adipocyte thermogenesis and energy expenditure

Qian, Wang; Li, Dehai; Cao, Guangchao; Shi, Qiankun; Zhu, Jing; Zhang, Mingyue; Cheng, Hao; Wen, Qiong; Xu, Hao; Zhu, Leqing; Zhang, Hua; Perry, Rachel J.; Spadaro, Olga; Yang, Yunfan; He, Shengqi; Chen, Yong; Wang, Baocheng; Li, Guangqiang; Liu, Zonghua; Yang, Caixian; Wu, Xiaoli; Zhou, Libing; Zhou, Qinghua; Ju, Zhenyu; Lu, Hongyun; Xin, Yongjie; Wang, Cunchuan; Liu, Yong; Shulman, Gerald I.; Dixit, Vishwa Deep; Lu, Ligong; Yang, Hengwen; Flavell, Richard A.; Yin, Zhinan

doi:10.1038/s41586-021-04127-5

Cited by 87 publications

(69 citation statements)

References 23 publications

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“…One of the inflammation-associated factors, interleukin-27 (IL-27), has been found to be significantly reduced in obese individuals and can be restored after bariatric surgery ( 54 ). IL-27 signaling promotes thermogenesis and energy expenditure, and protects mice from diet-induced obesity and insulin resistance.…”

Section: Recent Progress In Targeting Human Brown/beige Adipose Tissu...mentioning

confidence: 99%

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Pan

Chen

2022

Front. Endocrinol.

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Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity). It could be the origin of various metabolic disorders including hypertension, hyperlipidemia, type 2 diabetes, cardiovascular diseases etc. Active adipose tissue was discovered in humans through 18F-fluorodeoxyglucose Positron Emission Tomography coupled with Computer Tomography (18F FDG-PET/CT), which was initially performed for tumor scanning. Since human active adipose tissue is probably composed of brown and beige adipose tissues and they burn white adipose tissue to generate heat, targeting human brown/beige adipose tissue to induce their thermogenic function is considered significant to combat obesity. In this review, we describe the latest advancements on promising therapeutic strategies to combat obesity by targeting human thermogenic adipose tissues to achieve further metabolic balance in humans.

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Section: Recent Progress In Targeting Human Brown/beige Adipose Tissu...mentioning

confidence: 99%

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Pan

Chen

2022

Front. Endocrinol.

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“…In the ARC of the hypothalamus of adult mice, IL6 and its canonical receptor are detected, and elevated expression of IL6 protects mice from DIO ( Bobbo et al, 2021 ). Most recently, scientists figured out IL-27-IL-27Rα signaling in protecting against DIO and ameliorating IR ( Wang Q. et al, 2021 ) but whether IL-27 is associated with inflammation alleviation in CNS as the base of common characteristics of obesity and neuroinflammation still remains further explore.…”

Section: The Role Of Neuroinflammation In Obesity- or Overnutrition-a...mentioning

confidence: 99%

Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation

et al. 2022

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Overnutrition-related obesity has become a worldwide epidemic, and its prevalence is expected to steadily rise in the future. It is widely recognized that obesity exerts negative impacts on metabolic disorders such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases. However, relatively fewer reports exist on the impairment of brain structure and function, in the form of memory and executive dysfunction, as well as neurogenerative diseases. Emerging evidence indicates that besides obesity, overnutrition diets independently induce cognitive impairments via multiple mechanisms. In this study, we reviewed the clinical and preclinical literature about the detrimental effects of obesity or high-nutrition diets on cognitive performance and cerebral structure. We mainly focused on the role of brain insulin resistance (IR), microbiota-gut-brain axis, and neuroinflammation. We concluded that before the onset of obesity, short-term exposure to high-nutrition diets already blunted central responses to insulin, altered gut microbiome composition, and activated inflammatory mediators. Overnutrition is linked with the changes in protein expression in brain insulin signaling, leading to pathological features in the brain. Microbiome alteration, bacterial endotoxin release, and gut barrier hyperpermeability also occur to trigger mental and neuronal diseases. In addition, obesity or high-nutrition diets cause chronic and low-grade systematic inflammation, which eventually spreads from the peripheral tissue to the central nervous system (CNS). Altogether, a large number of unknown but potential routes interact and contribute to obesity or diet-induced cognitive impairment. The challenge for future research is to identify effective interventions involving dietary shifts and personalized therapy targeting the underlying mechanisms to prevent and improve cognition deficits.

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“…Conversely, sympathetic neuron-associated macrophages ( Cx3cr1 + SAMs) that are recruited to the nerve bundles of WAT during obesity can degrade norepinephrine, which is otherwise crucial for lipolysis and thermogenesis [ 113 ]. However, the Cx3cr1 + macrophages are reportedly IL27 producers, where administration of IL27 protects against IR and obesity through its direct actions on Ucp1 high adipocytes [ 118 ]. Such functional discrepancies of ATMs add another layer of complexity to the heterogeneity of AT immune populations.…”

Section: Reprogramming By Immune Modulationmentioning

confidence: 99%

The shades of grey in adipose tissue reprogramming

Hui

2022

Bioscience Reports

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The adipose tissue (AT) has a major role in contributing to obesity-related pathologies through regulating systemic immuno-metabolism. The pathogenicity of the AT is underpinned by its remarkable plasticity to be reprogrammed under the condition of obesity, in the perspectives of tissue morphology, extracellular matrix (ECM) composition, angiogenesis, immuno-metabolic homeostasis and circadian rhythmicity. Dysregulation in these features escalates the pathogenesis conferred by this endo-metabolic organ. Intriguingly, the potential to be reprogrammed appears to be an Achilles' heel of the obese AT that can be targeted for the management of obesity and its associated comorbidities. Here, we provide an overview of the reprogramming processes of white AT (WAT), with a focus on their dynamics and pleiotropic actions over local and systemic homeostasis, followed by a discussion of potential strategies favouring therapeutic reprogramming. The potential involvement of AT remodelling in the pathogenesis of COVID-19 is also summarized and discussed.

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IL-27 signalling promotes adipocyte thermogenesis and energy expenditure

Cited by 87 publications

References 23 publications

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Latest Advancements on Combating Obesity by Targeting Human Brown/Beige Adipose Tissues

Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation

The shades of grey in adipose tissue reprogramming

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