“…Based on TFEA indicating enrichment for motifs for each of these factors among active enhancers at 120 min versus vehicle (false discovery rate <0.05), our data implicate the MEF2 family in mediating secondary gene expression responses to WSP. In addition to this family, the bZip transcription factor, MAFF , LHX4 , a lim homeobox factor, and the cytokine, IL-24 , which is implicated in lung and airway remodeling in response to different inflammatory stimuli, were also among the set of AHR targets we identified ( 52 , 53 , 54 , 55 ). Thus, the short-lived primary transcriptional response to WSP mediated by AHR includes targets that likely contribute to more sustained changes in gene expression, possibly in collaboration with other rapid transcriptional effectors of the response to WSP, such as the TCF–SRF family.…”