IL-23/IL-17/G-CSF pathway is associated with granulocyte recruitment to the lung during African swine fever

Karalyan, Zaven; Voskanyan, H.; Ter-Pogossyan, Z.R.; Saroyan, David; Каралова, Е М

doi:10.1016/j.vetimm.2016.08.005

Cited by 13 publications

(18 citation statements)

References 24 publications

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“…IL-23 promotes differentiation and proliferation of Th17 cells [ 9 , 10 ] that are involved in inflammation by stimulating cytokine and chemokine production by various cells, with subsequent recruitment of neutrophils [ 10 , 11 , 18 ]. Increased levels of IL-23/IL-17 may be crucial for the diapedesis of neutrophils into tissues in pigs [ 18 ]. A role for IL-23 in recruiting neutrophils would be a possibility in gilt endometrium as seen after catheter insertion.…”

Section: Discussionmentioning

confidence: 99%

Expression of IL-23 in gilt endometrium and oviduct after insemination with seminal plasma, spermatozoa or semen extender

et al. 2021

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Objective Insemination with spermatozoa, seminal plasma and extender, cause a rapid inflammatory response in pig endometrium, characterized by an influx of neutrophils into the uterus. The transient inflammatory response to semen involves cytokine induction. Potential functions for Interleukin-23 (IL-23) in the inflammatory response to different insemination treatments were examined by studying mRNA expression and immunostaining in gilt oviduct and endometrium 35–40 h after insemination. Insemination was performed with seminal plasma (SP), spermatozoa (SPZ) without SP in the extender Beltsville thawing solution (BTS), or BTS alone. In control gilts an insemination catheter was inserted without anything being inseminated. Results Results showed that IL-23 mRNA was expressed in oviduct and endometrium after insemination regardless of treatment. There was an approximate two- to fourfold increase in expression of IL-23 mRNA in catheter-insertion control compared with SPZ, SP and BTS treatment groups. IL-23 immunolabelling was detected in a small number of separate cells and in the sub-epithelial connective tissue of the endometrium, the endosalpinx of isthmus and infundibulum. Conclusion In conclusion, insemination with SP, SPZ in BTS, and BTS alone decreased the expression of IL-23 mRNA in the endometrium compared to catheter-insertion control, indicating a possible role for IL-23 in the inflammatory response after insemination in gilts.

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Section: Discussionmentioning

confidence: 99%

Expression of IL-23 in gilt endometrium and oviduct after insemination with seminal plasma, spermatozoa or semen extender

et al. 2021

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show abstract

“…IL-23 promotes differentiation and proliferation of Th17 cells [9,10] that are involved in in ammation by stimulating cytokine and chemokine production by various cells, with subsequent recruitment of neutrophils [10,11,18,]. Increased levels of IL-23/IL-17 may be crucial for the diapedesis of neutrophils into tissues in pigs [18]. A role for IL-23 in recruiting neutrophils would be a possibility in gilt endometrium as seen after catheter insertion.…”

Section: Discussionmentioning

confidence: 99%

Expression of IL-23 in gilt endometrium and oviduct after insemination with seminal plasma, spermatozoa or semen extender

Svensson

Jiwakanon

Fossum³

et al. 2021

Preprint

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Objective: Insemination with spermatozoa, seminal plasma and extender, cause a rapid inflammatory response in the pig endometrium, which is characterized by an influx of neutrophils into the uterus. The transient inflammatory response to semen involves cytokine induction. Potential functions for Interleukin-23 (IL-23) in the inflammatory response to different insemination treatments were examined by studying mRNA expression and immunostaining in gilt oviduct and endometrium 35-40 h after insemination. Insemination was performed with seminal plasma (SP), spermatozoa (SPZ) without SP in the extender Beltsville thawing solution (BTS), or BTS alone. In control gilts an insemination catheter was inserted without anything being inseminated. Results: Results showed that IL-23 mRNA was expressed in oviduct and endometrium. There was an approximate 2-4-fold increase in expression of IL-23 mRNA in catheter-only control compared with SPZ, SP and BTS treatment groups. IL-23 immunolabelling was detected in a small number of separate cells as well as in the sub-epithelial connective tissue of the endometrium, the endosalpinx of the isthmus and infundibulum. In conclusion, all fluids used for insemination decreased the expression of IL-23 mRNA in the endometrium compared to catheter-insertion alone, indicating a possible role for IL-23 in the inflammatory response after insemination in gilts.

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“…IL-23 promotes differentiation and proliferation of Th17 cells [13,16] that are involved in in ammation by stimulating cytokine and chemokine production by a variety of cells, with subsequent recruitment of neutrophils [2,11,16]. It has been suggested that increased levels of IL-23/IL-17 may be crucial for the diapedesis of neutrophils into tissues in pigs [11]. A role for IL-23 in recruitment of neutrophils would be a possibility in gilt endometrium as seen after catheter insertion.…”

Section: Discussionmentioning

confidence: 99%

Expression of IL-23 in Gilt Endometrium and Oviduct After Insemination With Seminal Plasma, Spermatozoa or Semen Extender

Svensson

Jiwakanon

Fossum³

et al. 2020

Preprint

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Background: Signaling between seminal fluid and the female reproductive tract is required for a successful pregnancy to occur. Insemination with spermatozoa, seminal plasma and extender, is known to cause a rapid inflammatory response in the pig endometrium, which is characterized by an influx of neutrophils into the uterus. The temporary inflammatory response to semen involves induction of cytokines. In this study, potential functions for Interleukin-23 (IL-23) in the inflammatory response to different insemination treatments were examined by studying mRNA expression and immunostaining in samples of gilt oviduct (isthmus and infundibulum) and endometrium collected 35-40 h after insemination. Insemination was performed with either seminal plasma (SP, n = 4), spermatozoa in the extender Beltsville thawing solution (BTS) (SPZ, n = 4), or BTS alone (n = 4). In control gilts (n = 4) an insemination catheter was inserted without anything being inseminated. Any relation between expression of IL-23 and the presence of polymorphonuclear neutrophilic granulocytes (PMNs) in the endometrium was examined. Results: Results showed that IL-23 mRNA was expressed in the oviduct and in the endometrium. There was a significantly lower IL-23 mRNA expression in samples from gilts in the SPZ, SP and BTS treatment groups, compared with the controls. The control group also displayed significantly more neutrophils in samples collected 35-40 h after insemination compared with samples from the SP group. IL-23 immunolabelling was detected in a small number of separate cells as well as in the sub-epithelial connective tissue of the endometrium, the endosalpinx of the isthmus and infundibulum.Conclusions: All fluids used for insemination decreased the expression of IL-23 mRNA in the endometrium compared to catheter-insertion alone, indicating a possible role for IL-23 in the inflammatory response after insemination in gilts.

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IL-23/IL-17/G-CSF pathway is associated with granulocyte recruitment to the lung during African swine fever

Cited by 13 publications

References 24 publications

Expression of IL-23 in gilt endometrium and oviduct after insemination with seminal plasma, spermatozoa or semen extender

Expression of IL-23 in gilt endometrium and oviduct after insemination with seminal plasma, spermatozoa or semen extender

Expression of IL-23 in gilt endometrium and oviduct after insemination with seminal plasma, spermatozoa or semen extender

Expression of IL-23 in Gilt Endometrium and Oviduct After Insemination With Seminal Plasma, Spermatozoa or Semen Extender

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