IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22

Wu, Paul W.; Li, Jing; Kodangattil, Sreekumar; Luxenberg, Deborah; Bennett, Frann; Martino, Margot; Collins, Mary; Dunussi‐Joannopoulos, Kyriaki; Gill, Davinder; Wolfman, Neil M.; Fouser, Lynette A.

doi:10.1016/j.jmb.2008.07.046

Cited by 49 publications

(45 citation statements)

References 46 publications

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“…5a). These IL-10R2 binding sites are formed by IL-22 residues placed on helices A and D, in line with alanine scanning mutagenesis analysis [151,158]. Furthermore, it was proposed that IL-10R2 also contacts IL-22R1 via their respective D2 domains and the three IL-10R2 binding interfaces were named sites 2a, 2b, and 2c [27].…”

Section: Binary and Ternary Complexes Modelsmentioning

confidence: 69%

“…However, site-direct mutagenesis followed by cell-based assays and binding studies [151,153,158] have generated experimental data to propose structural models for the interleukin ternary complex. The 3D structures of the IL-22/IL-22R1 [27,28] and IL-10/IL-10R1 [117] binary complexes confirm previous suggestions of the overall location of the first receptor binding sites on IL-10 and IL-22 and also contribute to a better understanding of the second receptor interface, and hence, the overall ternary complex structure [27,28,117,153].…”

Section: The Il-22/il-22bp Structure and Interfacesmentioning

confidence: 99%

“…Putative IL-10R2 binding site at the IL-22:IL-22R1 binary complex Several lines of evidence suggest that the IL-10R2 binding site is located at helices A and D of IL-22 [27,28,151,158]. Initially, site-directed mutagenesis and surface-plasmon resonance analysis revealed that IL-22 residues (placed on helices A and D) Tyr51, Asn54, Arg55, Tyr114, and Glu117 are important for IL-10R2 engagement with IL-22/IL-22R1 binary complex [151].…”

Section: Binary and Ternary Complexes Modelsmentioning

confidence: 99%

“…Initially, site-directed mutagenesis and surface-plasmon resonance analysis revealed that IL-22 residues (placed on helices A and D) Tyr51, Asn54, Arg55, Tyr114, and Glu117 are important for IL-10R2 engagement with IL-22/IL-22R1 binary complex [151]. Later, an extensive mutagenesis study screening of 146 different IL-22 residues also included IL-22 Ile14, Thr56, Lys61, Ala66, Val83, Arg88, Pro113, Phe121, Leu122, and Met172 as important residues for IL-10R2 binding [158].…”

Section: Binary and Ternary Complexes Modelsmentioning

confidence: 99%

“…5b). Additional residues placed nearby IL-22 helix A bent, such as Met172, were also identified in mutagenesis screening analysis [158] and are therefore likely to contribute to IL-10R2 stabilization on site 2b. On the other hand, site 2c is formed by residues located in the IL-22R1 and IL-10R2 D2 domains.…”

Section: Binary and Ternary Complexes Modelsmentioning

confidence: 99%

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Structure and function of interleukin-22 and other members of the interleukin-10 family

Trivella

Ferreira-Junior

Dumoutier

et al. 2010

Cell. Mol. Life Sci.

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The IL-10 family of cytokines is comprised of IL-10, . The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved in several human diseases and health conditions and hence their structural analyses may provide valuable information to design specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology.

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Section: Binary and Ternary Complexes Modelsmentioning

confidence: 69%

Section: The Il-22/il-22bp Structure and Interfacesmentioning

confidence: 99%

Section: Binary and Ternary Complexes Modelsmentioning

confidence: 99%

Section: Binary and Ternary Complexes Modelsmentioning

confidence: 99%

Section: Binary and Ternary Complexes Modelsmentioning

confidence: 99%

See 3 more Smart Citations

Structure and function of interleukin-22 and other members of the interleukin-10 family

Trivella

Ferreira-Junior

Dumoutier

et al. 2010

Cell. Mol. Life Sci.

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The Biology and Functions of Th22 Cells

Jia

2014

Advances in Experimental Medicine and Biology

101

100

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T helper (Th) cells develop from naïve CD4(+) T cells under lineage-specific culture conditions and are nominated by their lineage-specific cytokines. Th22 cells, new players in adoptive immune responses, are identified by the production of interleukin (IL)-22. Plenty of observations are obtained over the past few years indicating that IL-22 is produced by activated T cells including Th22 cells, Th17 cells, Th1 cells, innate lymphoid cells and some nonlymphocytes. IL-22 functions synergistically with IL-17 or tumor necrosis factor (TNF), however, it plays different roles by IL-22/IL-22 receptor signal transductions in pathologic processes, including inflammations, autoimmunity, tumor, and digestive organs damages. In this chapter, we focus on the biology of IL-22, the generation and regulation of Th22 cells, the possible signal pathways that involved in the functions of Th22 cells, as well as the relationship between Th22 cells and various diseases.

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Biological and pathological activities of interleukin-22

et al. 2016

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Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22+CD4+ T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival and proliferation. Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection and malignancy. In this Review we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios, and discuss the potential to target IL-22 signaling to treat human diseases.

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IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22

Cited by 49 publications

References 46 publications

Structure and function of interleukin-22 and other members of the interleukin-10 family

Structure and function of interleukin-22 and other members of the interleukin-10 family

The Biology and Functions of Th22 Cells

Biological and pathological activities of interleukin-22

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