IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling

Costa, María M.; Saraceni, Paolo Roberto; Forn-Cuní, Gabriel; Dios, S.; Romero, Alejandro; Figueras, António; Novoa, Beatriz

doi:10.1016/j.dci.2013.08.021

Cited by 41 publications

(27 citation statements)

References 48 publications

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“…This enhanced expression of TLR-4A in infected zebrafish treated with JPtNPs can be correlated to inflammation. Inflammation onset is important for reducing the spread of infectious agents 25 and also for recruitment and activation of immune cells 26–28 . Our results shown that infection of zebrafish with A. hydrophila resulted in significant enhancement, (3 h post infection), in the expression of pro-inflammatory cytokines namely IL-1β (11.3-fold), IFN-γ (34-fold), TNF-α (10.24-fold) and iNOS (12.92-fold) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Ahmed

Raman

Veerappan

2018

Sci Rep

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Bacterial resistance is a major clinical problem, which is compounded by both a lack of new antibiotics and emergence of multi- and extremely-drug resistant microbes. In this context, non-toxic nanoparticles could play an important role in conferring protection against bacterial infections and in this study we have made an attempt to show the usefulness of jacalin capped platinum nanoparticles in protecting zebrafish against multiple infections with Aeromonas hydrophila. Our results also indicate that use of nanoparticles promotes adaptive immune response against the pathogen, so much so that zebrafish is able to survive repetitive infection even after twenty one days of being treated with jacalin-capped platinum nanoparticles. This is significant given that platinum salt is not antibacterial and jacalin is non-immunogenic. Our study for the first time reveals a novel mechanism of action of nanoparticles, which could form an alternate antibacterial strategy with minimal bacterial resistance.

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Section: Resultsmentioning

confidence: 99%

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Ahmed

Raman

Veerappan

2018

Sci Rep

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“…Intriguingly, IL-17 signaling, of high importance in anti-fungal immunity in humans, has been implicated in response to infection in zebrafish (Hernandez-Santos and Gaffen, 2012; Puel et al, 2012; Zhang et al, 2013). Consistent with a potential innate role for this pathway, recent work suggests that both IL-17 and IL-22 are expressed in juvenile zebrafish, at a development stage where the adaptive immune system is not fully functional (Costa et al, 2013; Danilova et al, 2004; Lam et al, 2004; Page et al, 2013; Quintana et al, 2010). Work in carp has implicated IL-17 and IL-23 in response to trypanosomes, along with the expected recruitment of neutrophils (Ribeiro et al, 2010).…”

Section: Immune Responses To Eukaryotic Infectionsmentioning

confidence: 81%

Utilization of zebrafish for intravital study of eukaryotic pathogen–host interactions

Gratacap

Wheeler

2014

Developmental & Comparative Immunology

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Unique imaging tools and practical advantages have made zebrafish a popular model to investigate in vivo host–pathogen interactions. These studies have uncovered details of the mechanisms involved in several human infections. Until recently, studies using this versatile host were limited to viral and prokaryotic pathogens. Eukaryotic pathogens are a diverse group with a major impact on the human and fish populations. The relationships of eukaryote pathogens with their hosts are complex and many aspects remain obscure. The small and transparent zebrafish, with its conserved immune system and amenability to genetic manipulation, make it an exciting model for quantitative study of the core strategies of eukaryotic pathogens and their hosts. The only thing to do now is realize its potential for advancement of biomedical and aquaculture research.

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“…Some genes involved in the antibacterial, e.g. antimicrobial peptides IL-8, were regulated by this cytokine (Monte et al, 2011;Costa et al, 2013). The increase of IL-22 by Chlorella suggested that Chlorella might be involved in the regulation of fish anti-inflammatory and immunostimulatory functions.…”

Section: Resultsmentioning

confidence: 98%

Effects of Dietary Administration of Chlorella on the Immune Status of Gibel Carp, Carassius Auratus Gibelio

Zhang

Qiu

et al. 2014

Italian Journal of Animal Science

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In the present study the effects of dietary Chlorella on the immune status of gibel carp, Carassius auratus gibelio, were evaluated. A total of 540 healthy fish were divided into 6 groups, with one control group fed with Chlorella-free diet and five experimental groups fed diets supplemented with 0.4 to 2.0% Chlorella. The whole trial lasted 60 days. At the end of the trial, the weight gain and immune parameters of fish were analysed. Results showed that Chlorella could increase the levels of immunoglobulin M and D, interleukin-22 and chemokine (C-C motif) ligand 5 in some tissues, which indicated that dietary Chlorella can be involved in regulating adaptive and innate immunity.

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IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling

Cited by 41 publications

References 48 publications

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Jacalin capped platinum nanoparticles confer persistent immunity against multiple Aeromonas infection in zebrafish

Utilization of zebrafish for intravital study of eukaryotic pathogen–host interactions

Effects of Dietary Administration of Chlorella on the Immune Status of Gibel Carp, Carassius Auratus Gibelio

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