IL-21 Administration into the Nostril Alleviates Murine Allergic Rhinitis

Hiromura, Yayoi; Kishida, Tsunao; Nakano, Hiroshi; Hama, Takemitsu; Imanishi, Jirô; Hisa, Yasuo; Mazda, Osam

doi:10.4049/jimmunol.179.10.7157

Cited by 76 publications

(73 citation statements)

References 62 publications

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“…Furthermore, the IL-21 treated mice with AR had significantly reduced serum levels of sIgE and decreased levels of Th2 cytokines (IL-4, IL-5 and IL-13) in the nasal tissues. In addition, the eosinophil selective chemokine-1 and 2 were reduced in IL-4 induced fibroblasts, which inhibited the migration of eosinophils into the nasal tissues (19). Our result indicated there was no significant difference in the serum IL-21 level between AR patients and healthy controls (P>0.05), and IL-21 was not associated with serum sIgE, IL-21, IL-17 and IL-23.…”

Section: Discussionmentioning

confidence: 57%

Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis Patients

Huang¹,

Yang²,

Chen³

et al. 2011

Journal of Medical Biochemistry

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Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis PatientsThe present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum. AR patients (n=24) and healthy subjects (n=12) were recruited and serum samples were collected. The serum level of IgE specific for inhalant allergens was determined using the automatic quantitative immunofluorescence analysis system, and the contents of IL-17, IL-21 and IL-23 in the serum were detected using ELISA. The level of serum IgE in the healthy individuals was categorized as grade 0 and that in the AR patients as grade 2-6. The mean contents of IL-17, IL-21 and IL-23 were 164.71 ±39.37 pg/mL, 199±97.86 pg/mL and 78.94±26.33 pg/mL, respectively, in the AR patients, and 67.75±18.24 pg/mL, 7.58±5.49 pg/mL and 13.58± 3.93 pg/mL, respectively, in the healthy subjects. Statistical analysis showed the serum levels of IL-17 and IL-23 in the AR patients were markedly higher than those in the healthy subjects, however, no significant difference was noted in the content of IL-21. Furthermore, the IL-17 level was positively related to the levels of IL-23 and IgE and the IL-23 level was positively related to the IgE level among AR patients, but no relations were observed between the IL-21 level and levels of IL-17, IL-23 and IgE. Our study indicates IL-17 and IL-23 may play an important role in the pathogenesis of AR and maybe IL-21 is not involved in the occurrence of AR.

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Section: Discussionmentioning

confidence: 57%

Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis Patients

Huang¹,

Yang²,

Chen³

et al. 2011

Journal of Medical Biochemistry

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“…(Table I). Some insight into the role of IL-21 in allergic responses came from studies showing that exposure to IL-21 resulted in decreased IgE production in an OVA-induced mouse model of allergic rhinitis and in a mouse food allergy model (54,55). In humans, diminution of IgE production has been reported following vaccination with Mycobacterium bovis bacillus Calmette Guerin, BCG (56).…”

Section: Il-21 In Diseasementioning

confidence: 99%

IL-21: An Executor of B Cell Fate

Konforte

Simard

Paige

2009

The Journal of Immunology

132

100

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IL-21 is a type I cytokine that shares the common receptor γ-chain with IL-2, IL-4, IL-7, IL-9, and IL-15. B cells are one of the lymphoid cell types whose development and function are regulated by IL-21. Depending on the interplay with costimulatory signals and on the developmental stage of a B cell, IL-21 can induce proliferation, differentiation into Ig-producing plasma cells, or apoptosis in both mice and humans. Alone and in combination with Th cell-derived cytokines IL-21 can regulate class switch recombination to IgG, IgA, or IgE isotypes, indicating its important role in shaping the effector function of B cells. This review highlights the role of IL-21 in B cell development, function, and disease and provides some perspectives on the future studies in this area.

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“…We recently found that administration of recombinant mouse IL-21 (rmIL-21) into the nostril of allergic-rhinitis mice significantly inhibited the nasal-allergic reactions as well as IgE CSR in nasal-associated lymphoid tissues (23), although molecular basis for the linkage between IL-21 signal and IgE regulation remains to be elucidated.…”

mentioning

confidence: 99%

IL-21 Induces Inhibitor of Differentiation 2 and Leads to Complete Abrogation of Anaphylaxis in Mice

Kishida

Hiromura

Shin‐Ya

et al. 2007

The Journal of Immunology

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IL-21 exerts pleiotrophic immunomodulatory activities on a variety of target cells including B cells that undergo class switch recombination (CSR) to IgE. In this study, we examined whether IgE-mediated systemic anaphylaxis was controlled by in vivo administration of IL-21 using the peanut allergy model in mice and investigated the molecular mechanisms underlying the IL-21-induced regulation of IgE. The anaphylactic reaction was completely abolished by the administration of recombinant mouse IL-21 or an IL-21 expression plasmid in terms of the change of body temperature and anaphylactic symptoms. The recombinant mouse IL-21 treatment remarkably suppressed IgE CSR in splenic B cells, resulting in significant decrease in serum concentrations of total as well as allergen-specific IgE. In the meanwhile, IL-21 provoked B cells in normal as well as allergic mice to express the inhibitor of differentiation 2 (Id2) gene that was shown to be crucially involved in the regulation of the activation-induced cytidine deaminase and IgE CSR. Moreover, mice genetically deficient for Id2 were completely unsusceptible to IL-21-induced prevention of IgE CSR and anaphylaxis. The present study strongly suggests that IL-21 is capable of regulating systemic allergic reactions by inducing the transcriptional regulator Id2, and the cytokine may be useful for clinical intervention for allergic diseases including anaphylaxis.

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IL-21 Administration into the Nostril Alleviates Murine Allergic Rhinitis

Cited by 76 publications

References 62 publications

Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis Patients

Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis Patients

IL-21: An Executor of B Cell Fate

IL-21 Induces Inhibitor of Differentiation 2 and Leads to Complete Abrogation of Anaphylaxis in Mice

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