Il-2 Induces Pha Proliferation in Peripheral Blood Mononuclear Cells from Cluster Headache Patients

Stirparo, Giuseppe; Martelletti, Paolo; Stefano, L.; Giacovazzo, M; Rinaldi, Christian

doi:10.1177/0333102491011s11144

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1993

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“…The IL-1 beta increase that we measured during the ictal phase of CH could be stress-related, but this would not account for the high values detected during the interictal phase of CH. The IL-1 beta increase could also represent a positive feedback signal from the immune system to counteract the defective expression of the IL-2 receptors recorded in CH patients independent of the cluster period (12). Alternatively, the IL-1 beta in-crease may be in response to the previously described low functional activity of the NK cells in CH (13), another example of feedback because IL-1 increases the activity of these cells.…”

Section: Discussionmentioning

confidence: 91%

Serum Interleukin-1 Beta is Increased in Cluster Headache

1993

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We measured serum interleukin-1 beta (IL-1 beta) in 24 episodic cluster headache (CH) patients and 45 normal controls using a specific ELISA method. There was an increase in IL-1 beta in all CH patients compared to controls. IL-1 beta was further increased during the ictal phase of CH compared to patients between attacks and normal individuals. Between attacks, IL-1 beta was also significantly increased compared to controls. We suggest that these results represent an activation of the immune system in CH.

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Section: Discussionmentioning

confidence: 91%