IL-1β, IL-6, TNFα, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis

Mattsby‐Baltzer, Inger; Platz-Christensen, JensJ.; Hosseini, Nosrat; Rosén, Petra

doi:10.1080/j.1600-0412.1998.770701.x

Cited by 57 publications

(22 citation statements)

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“…However, the lack of information on chorioamnionitis made it difficult to determine whether the G‐CSF link to very preterm delivery was indicative of an infection pathway, or was related to the shorter time from sampling to delivery in this window of gestation. In studies of vaginal fluid collected during pregnancy, IL‐1β, but not IL‐6, was correlated with bacterial vaginosis (BV) 57 , 65 …”

Section: Biomarkers Of the Infection Pathwaymentioning

confidence: 99%

Pregnancy outcomes and community health: the POUCH study of preterm birth

Holzman¹,

Bullen²,

Fisher

et al. 2001

Paediatric Perinatal Epid

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In light of the social/ethnic disparity in preterm delivery (PTD) rates, the Pregnancy Outcomes and Community Health (POUCH) Study takes a broad view of the determinants of PTD by attempting to link underlying biological and psychosocial factors. The relationships between placental pathology, maternal biomarkers, and antecedent psychosocial factors are evaluated in three hypothesised pathways of PTD – one characterised primarily by infection, one by maternal vascular disease, and one by premature elevations in corticotropin releasing hormone in the absence of histological evidence of placental pathology. Within each pathway, an emphasis is placed on understanding the roles of stress and of maternal serum alpha‐fetoprotein, an early biomarker associated with PTD. The POUCH Study enrols pregnant women from five Michigan communities. Information about these women and their environments is gathered through detailed interviews and collection of biological samples including hair, urine, saliva, blood, vaginal fluid, and vaginal smear at 15–26 weeks of gestation. We have chosen to focus on the second trimester – a time when pathological processes may have evolved to a detectable stage, but generally before the onset of biological changes that accompany labour. This focus is consistent with the long‐range goal of early detection/intervention and prevention of PTD.

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Section: Biomarkers Of the Infection Pathwaymentioning

confidence: 99%

Pregnancy outcomes and community health: the POUCH study of preterm birth

Holzman¹,

Bullen²,

Fisher

et al. 2001

Paediatric Perinatal Epid

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“…However, while some authors reported a correlation between vaginal/cervical secretions and amniotic fluid IL‐6 concentrations (13,14), others did not (15). This may be explained by the local production of inflammatory markers in the cervix and the vagina (23,24). Nevertheless, elevated IL‐6 in cervical secretions after PPROM has been found by Rizzo et al and Jun et al to be associated with intrauterine infection (13,14).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil defensins but not interleukin‐6 in vaginal fluid after preterm premature rupture of membranes predict fetal/neonatal inflammation and infant neurological impairment

Lučovnik¹,

Kornhauser‐Cerar²,

Premru-Sršen³

et al. 2011

Acta Obstet Gynecol Scand

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“…Purified endotoxin from P. bivia is clearly able to induce a cytokine response in monocytic cells [30]. …”

Section: 1 Discussionmentioning

confidence: 99%

Prevotella bivia as a source of lipopolysaccharide in the vagina

2008

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Objectives-To compare vaginal lipopolysaccharides (LPS) concentrations between patients with and without bacterial vaginosis (BV), to evaluate the correlation between Prevotella bivia colonization density and LPS concentration, and to determine the impact of LPS on loss of dopamine neurons (DA).Methods-Vaginal washes obtained from patients with (n=43) and without (n=59) BV were tested for quantity of P. bivia cells using quantitative PCR and for concentrations of LPS using the Limulus Amebocyte Lysate gel clot method. Prevotella bivia, Gardnerella vaginalis and Escherichia coli sonicated cell extracts were also tested for LPS production. DA neuron cells obtained from embryonic day (E) 14.5 pregnant rats were exposed to fluid from eight vaginal washes; tyrosine hydrolase immunoreactive staining was applied for visualization and cell counts.Results-The median LPS concentrations were dramatically higher among patients who had symptoms of BV compared to those who did not have symptoms (3235.0 vs 46.4 EU/ml, respectively, P<0.001); patients who had BV also had much higher colonization densities of P. bivia (0.06±0.36 vs 5.4±2.2 log 10 CFU/ml, respectively, P<0.001).Prevotella bivia cell lysates resulted in a higher LPS concentration (10,713.0±306.6 EU/ml) than either E. coli (4,679.0± 585.3 EU/ml) or G. vaginalis (0.07±0.01 EU/ml of LPS).The loss of DA neuron was 20-27% in cultures treated with vaginal washes from BV-negative patients and 58-97% in cultures treated with vaginal washes from patients with BV. Fax: (312) 864-9522, E-mail: aaroutch@rush.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. It has been shown that an increased rate of premature labor and preterm delivery [1-3] occurrs among women with P. bivia at a concentration of >10 4 bacteria/ml of vaginal fluid [4]. An experimental rabbit model also confirmed an association between P. bivia and preterm birth, increased level of TNF-α, and chronic intrauterine and fetal infection [5]. A persistent intrauterine inflammatory state that can occur in chronic conditions such as BV suggests that preterm delivery may follow chronic exposure to organisms, perhaps with resulting fetal brain damage [6,7]. Conclusion-P. bivia produces high LPS concentration NIH Public AccessPrevotella bivia and other Prevotella species contain endotoxin, lipopolysaccharides (LPS), on their outer membranes; LPS is the most potent antigenic component of the Gram-negative bacterial cell wall. Some species of Prevotella produce LPS that is much more potent in inducing a rapid platelet response than the LPS found in Escherichia coli a...

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IL-1β, IL-6, TNFα, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis

Abstract: BV is associated with increased levels of IL-1beta in the lower genital tract of pregnant women in the first trimester. The ability of BV-associated endotoxins to induce cytokine production in monocytic cells may partly explain the increased IL-1beta levels.

Cited by 57 publications

References 0 publications

Pregnancy outcomes and community health: the POUCH study of preterm birth

Pregnancy outcomes and community health: the POUCH study of preterm birth

Neutrophil defensins but not interleukin‐6 in vaginal fluid after preterm premature rupture of membranes predict fetal/neonatal inflammation and infant neurological impairment

Prevotella bivia as a source of lipopolysaccharide in the vagina

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