IL-1β a potential factor for discriminating between thyroid carcinoma and atrophic thyroiditis

Kammoun-Krichen, Maha; Bougacha-Elleuch, Noura; Mnif, Mouna; Bougacha, Fadia; Charffedine, Ilhem; Rebuffat, Sandra A.; Rebai, Ahmed; Glasson, Emilie; Abid, M.; Ayadi, Fatma; Péraldi-Roux, Sylvie; Ayadi, Hammadi

doi:10.1684/ecn.2012.0312

Cited by 15 publications

(12 citation statements)

References 24 publications

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“…Also, there was a highly significant increase in FT4 obtained from thyroiditis group as compared to thyroid cancer group (p=0.04). This result was confirmed by data obtained by several authors [10,11].…”

Section: Effect Of Gender On Tmda Level In Different Studied Groupssupporting

confidence: 89%

Biochemical Study of Gender Effect on Thyroid Cancer in the Egyptian Population

Zahran

Hamed

Yosry

et al. 2019

AJRB

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Background and Objective: Thyroid is one of the largest glands; its hormones affect almost every cell in the body, the incidence of thyroid cancer has raised in recent years, About 52,070 new cases of thyroid cancer in the United States in 2018 only. This study was undertaken to determine if gender was associated with susceptibility of thyroid cancer. Materials and Methods: This study was carried out on 174 cases divided into 108 thyroid patients and 66 healthy as controls. The mean age of cases was (40.58±1.46) they include 48 female and 18 males. All participants were subjected to an estimation of thyroid stimulating hormone (TSH), free thyroxine (FT4), total antioxidant capacity (TAC), in addition to malondialdehyde (MDA). Results: For TSH results that was an obvious effect of gender on TC, while for FT4 there was an effect of gender on thyroiditis and TC, for TAC there was a biting effect on thyroiditis and TC, for MDA there was an effect also on thyroiditis and TC, for tissue TAC (TTAC) that was a clear effect of gender on both thyroiditis and TC, and for TMDA there was a little effect. Conclusion: Gender of TC patients effects on biochemical investigations of the thyroid.

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Section: Effect Of Gender On Tmda Level In Different Studied Groupssupporting

confidence: 89%

Biochemical Study of Gender Effect on Thyroid Cancer in the Egyptian Population

Zahran

Hamed

Yosry

et al. 2019

AJRB

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“…and decreased levels of IL-1β, IFN-α and TGF-β1 in PTC patients compared with controls, in agreement with previous studies regarding IL-6 10,22 and IL-1β levels. 9 The multiple logistic regression analysis further revealed that only IFN-α and TGF-β1 significantly and efficiently discriminated PTC patients from controls (Figure 1). tumour growth and metastasis.…”

Section: Discussionmentioning

confidence: 91%

“…1,6 Thyroidectomy is frequently performed in these inconclusive cases for definitive identification; however, patients undergoing surgery without malignant tumours are exposed to unnecessary risk, demanding the search for non-invasive biomarkers to improve risk assessment and preoperative diagnosis. 7 There is a recognised association between the inflammatory microenvironment and TC, 8 and altered levels of both regulatory and inflammatory cytokines in PTC have already been reported, including interleukins (IL)-1β, 9 IL-6 10 and interferon (IFN)-α. 11 Certain cytokines released by inflamed tissues can reciprocally influence the expression of the human leucocyte antigen-G (HLA-G) molecule, 12 which is an important immunomodulator of the tumoural immune response.…”

Section: Introductionmentioning

confidence: 99%

Plasma levels of soluble HLA‐G and cytokines in papillary thyroid carcinoma before and after thyroidectomy

Bertol

Araújo

Sadissou

et al. 2020

Int. J. Clin. Pract.

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Background Increasing evidence shows that chronic inflammation plays an important role in thyroid tumorigenesis. Cytokines as central mediators in inflammatory microenvironment can present both pro‐tumour and anti‐tumour effects and cytokine release may be influenced by soluble HLA‐G (sHLA‐G), an immune checkpoint molecule whose expression can also be induced by certain cytokines. Aim To understand the role of these soluble factors in papillary thyroid cancer (PTC). Methods We evaluated plasma levels of sHLA‐G and of 13 cytokines using ELISA and flow cytometry, respectively, in PTC patients at two time points: pre‐ and post‐thyroidectomy; and control subjects. Results Compared with controls, IL‐6 levels were increased, while IL‐1β, IFN‐α and TGF‐β1 levels were decreased in pre‐thyroidectomy PTC patients. IFN‐α and TGF‐β1 efficiently discriminated patients from controls and were associated with extrathyroidal extension and lymph node metastasis, respectively. In addition, TNF and IL‐13 were associated with male gender, lymph node metastasis and Hashimoto thyroiditis, and sHLA‐G with tumour invasion. Compared with pre‐thyroidectomy, IL‐4, IL‐10, TNF, IFN‐α and TGF‐β1 levels were increased in post‐thyroidectomy. Conclusion There are significant changes in the cytokine profile after surgical removal of the thyroid tumour, and IFN‐α e TGF‐β1 showed to be promising cytokines for discriminating PTC patients from controls. We also found that different cytokines are associated with clinicohistopathological characteristics of PTC related to poor prognosis, suggesting that cytokines seem to play an important role in PTC development and management.

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“…These results are in agreement with a result of Marchiori and coworkers (2015) who showed elevate in the serum grade of IL-1β in hypothyroid Patients. As well as, Kammoun-Krichen et al (2012) revealed elevation in the level of IL-1β in hypothyroid patients and suggested the possibility of using it to distinguish between thyroid diseases. On the other hand, the present result is disagreement with the result reported by Phenekos and colleagues (2004) who found a decrease in IL-1β level in Hashimoto patients than Graves's disease (GD) and control.…”

Section: Resultsmentioning

confidence: 89%

“…Actually, it is famed that IL-1β effect the work of thyroid cells by reducing the term of Tg and TPO, that intensity of IL-1β alter thyroid epithelial hardship of human thyrocytes by changing the expression, localization and regulation of cross proteins, supported the remarkable part played by IL-1β in thyroid pathogenesis (Kammoun-Krichen et al, 2012). About Il-1β in patients group with periodontitis, Raunio et al (2007) and Hajishengallis (2014) reported that the rise in serum IL-1β might be demonstrated both by seep of the locally generated IL-1β from the inflamed periodontal region and by systemic output in reply to the systemically sparse antigen capacity.…”

Section: Resultsmentioning

confidence: 99%

Interleukin-1β, interleukin-6 and tumour necrosis factor-alpha levels in blood and saliva in hypothyroidism accompanied with periodontitis

Al-Hindawi¹,

Al-Ghurabi²

2019

ijrps

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Relationship between thyroid dysfunction and periodontal disease has been mediated through an immune response. Cytokines are implicated in the initiation, consequences of immune response and a crucial role in the pathogenesis of thyroid disease, directly target thyroid follicular cells; and in the development and progression of periodontitis. This study aimed to detect cytokines levels which known to be associated with periodontitis in serum and saliva, to test the hypothesis that hypothyroidism influences the levels of biomarkers of periodontitis. Samples were collected from sixty patients with hypothyroid age ranged (20-64) years, thirty of patients were without periodontitis (group I) and 30 with periodontal disease (II); moreover, 30 subjects considered as control (group III) with age (20-53) years. Detection of cytokines was performed by ELISA. The results showed a significant elevation in serum and salivary levels of IL-1β (P<0.001) among patients’ groups (I and II) as compared to group III, as well IL-1β increase significantly in group II (P<0.001) than in group I and also than group III. There are non-significant differences (P>0.05) in serum level of IL-6 and TNF-α and salivary levels of TNF-α among all study groups. Nevertheless, the salivary level of IL-6 is increased significantly (P<0.05) in group II as compared with group I and group III, and their non-significant differences (P<0.05) between groups I and III. The present finding proposed that hypothyroidism might encourage periodontitis development; as well as serum and salivary levels of IL-1β, with salivary IL-6 may represent important biomarkers for the early detection of periodontitis in hypothyroid patients.

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IL-1β a potential factor for discriminating between thyroid carcinoma and atrophic thyroiditis

Cited by 15 publications

References 24 publications

Biochemical Study of Gender Effect on Thyroid Cancer in the Egyptian Population

Biochemical Study of Gender Effect on Thyroid Cancer in the Egyptian Population

Plasma levels of soluble HLA‐G and cytokines in papillary thyroid carcinoma before and after thyroidectomy

Interleukin-1β, interleukin-6 and tumour necrosis factor-alpha levels in blood and saliva in hypothyroidism accompanied with periodontitis

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