IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population

Segat, Ludovica; Bevilacqua, Daiana; Boniotto, Michele; Arraes, Luiz Cláudio; Souza, Paulo Roberto Eleutério de; Filho, José Luiz de Lima; Crovella, Sérgio

doi:10.1007/s00251-006-0104-7

Cited by 26 publications

(23 citation statements)

References 14 publications

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“…In our cohort no association with HCV infection susceptibility was found. However, Zhang et al [2005] and Segat et al [2006] found a close association between these polymorphisms and the susceptibility to hepatitis B and HIV infection respectively. Nevertheless, the carriage of at least one allele C at position À607 or G at position À137 seems to be a risk factor for developing more severe forms of CH.…”

Section: Discussionmentioning

confidence: 88%

Association of interleukin‐18 polymorphisms and plasma level with the outcome of chronic HCV infection

Bouzgarrou

Hassen

Schvoerer

et al. 2008

Journal of Medical Virology

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Hepatitis C virus (HCV) infection is the main cause of chronic liver disease throughout the world, and may progress to cirrhosis and hepatocellular carcinoma (HCC). Immunological factors, especially cytokines and some host genetic variations, rather than direct HCV action, seem to play an important role in the pathogenesis of HCV infection. Elevated levels of interleukin-18 (IL-18) were described previously for chronically (HCV)-infected patients. This study is aimed at investigating IL-18 promoter polymorphisms (-607C/A and -137G/C) in HCV-infected patients with different disease severities (chronic hepatitis C, liver cirrhosis and HCC) and establishing an association between these polymorphisms and IL-18 plasma concentration with the outcome of chronic HCV infection. The carriage of at least one C allele at position -607 (CC + CA) was associated with a higher risk of cirrhosis and HCC (P = 0.032). Compared with controls, HCV-infected patients had significantly higher levels of IL-18 (P = 0.0001) that correlate with disease severity (P = 0.01, P = 0.001, P = 0.0006, respectively). In conclusion, we supposed a possible implication of IL-18 promoter polymorphisms in the pathogenesis of chronic HCV infection.

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Section: Discussionmentioning

confidence: 88%

Association of interleukin‐18 polymorphisms and plasma level with the outcome of chronic HCV infection

Bouzgarrou

Hassen

Schvoerer

et al. 2008

Journal of Medical Virology

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“…The cytokine increases HIV replication, attenuates anti-viral innate and adaptive immunity, and contributes towards aberrant immune activation (reviewed in [116,117]). It is noteworthy that certain synonymous mutations in the IL-18 gene promoter that result in increased IL-18 production have been associated with increased susceptibility to the infection in children ( [118]; reviewed in [109]). A pathogenic role of IL-18 in HIV infections is supported by studies in animal models of Rhesus macaques and Cynomolgus monkeys as well.…”

Section: Consequences Of Il-18 Dysregulation In Hiv Infectionmentioning

confidence: 99%

Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection

et al. 2016

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“…In different populations, IL-18 gene polymorphism at either -607 or -137 position, or both, has been shown to influence the severity of many diseases, for example, Crohn's disease [11], cardiovascular diseases [12], and infectious diseases such as HIV infection [13] (Table 3). Polymorphisms of IL-18 gene promoter have also been shown to be closely associated with the susceptibility to chronic HBV infection [9].…”

Section: Discussionmentioning

confidence: 99%

“…Decreased HBV replication was also associated with -607 AA allele polymorphism. IL-18 gene polymorphism at -607 and -137 positions has been shown to be associated with Crohn's disease [11], cardiovascular diseases [12], and infectious diseases such as human immunodeficiency virus (HIV) infection [13]. However, there is no information on the relevance and significance of IL-18 promoter polymorphism at -607 and -137 positions in HCV.…”

Section: Introductionmentioning

confidence: 95%

Association of IL-18 promoter polymorphism with liver disease severity in HCV-infected patients

et al. 2009

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Introduction Interleukin (IL)-18 plays an important dual role in Th1 polarization and viral clearance, as well as in the development of liver fibrosis. Single-nucleotide promoter polymorphisms influence the transcription of IL-18 mRNA. Promoter polymorphisms are linked to delayed virus clearance and disease susceptibility in many diseases. However, there is no information about their role in hepatitis C virus (HCV) infection. Aim To investigate the association between -607 or -137 polymorphism with susceptibility and severity of HCV infection. Patients and methods Two hundred and four serologically proven patients with chronic HCV infection and 350 matched healthy controls were included in this study. Patients were segregated in 2 groups: group A with mild liver disease and group B with severe liver disease on the basis of histological activity index (HAI B5 or [5) and hepatic fibrosis score (B2 or [2). IL-18 promoter genotyping was performed with sequence-specific primers. Results There was no significant difference in the frequencies of -607 and -137 allelic distribution in patients and controls. The -607 A/A allele was more common in group A patients with mild liver disease than in patients with severe liver disease on the basis of HAI (38.6% vs.

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IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population

Cited by 26 publications

References 14 publications

Association of interleukin‐18 polymorphisms and plasma level with the outcome of chronic HCV infection

Association of interleukin‐18 polymorphisms and plasma level with the outcome of chronic HCV infection

Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection

Association of IL-18 promoter polymorphism with liver disease severity in HCV-infected patients

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