IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway

Kim, Jihye; Kim, Cherlhyun; Kim, Tae Sung; Bang, Sa Ik; Yang, Young; Park, Hyun-Jeong; Cho, Daeho

doi:10.1016/j.bbrc.2006.04.016

Cited by 61 publications

(48 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IL-18 enhanced the expression of phosphorylated JNK. Overall, these results suggest that IL-18 plays a key role in TSP-1 expression involving JNK (Kim et al, 2006). Endogenous IL-18 facilitate cancer cell immune escape by suppressing CD70 and increasing metastatic ability by upregulating CD44 and VEGF (Kang et al, 2009).…”

Section: Role Of Il-18 In Immune Evasuionmentioning

confidence: 72%

Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18

Kuppala¹,

Syed²,

Bandaru³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Interleukin-18 (IL-18) is an immune-stimulatory cytokine with antitumor activity in preclinical models. It plays pivotal roles in linking inflammatory immune responses and tumor progression and is a useful candidate in gene therapy of lymphoma or lymphoid leukemia. A phase I study of recombinant human IL-18 (rhIL-18) in patients with advanced cancer concluded that rhIL-18 can be safely given in biologically active doses to patients with advanced cancer. Some viruses can induce the secretion of IL-18 for immune evasion. The individual cytokine activity might be potentiated or inhibited by combinations of cytokines. Here we focus on combinational effects of cytokines with IL-18 in cancer progression. IL-18 is an important non-invasive marker suspected of contributing to metastasis. Serum IL-18 may a useful biological marker as independent prognostic factor of survival. In this review we cover roles of IL-18 in immune evasion, metastasis and angiogenesis, applications for chemotherapy and prognostic or diagnostic significance.

show abstract

Section: Role Of Il-18 In Immune Evasuionmentioning

confidence: 72%

Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18

Kuppala¹,

Syed²,

Bandaru³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…However, IL-18 has, by contrast, been shown to induce VEGF, promote endothelial cell migration and increase vascular tube formation in vitro and in vivo. 34,35 Kim et al 36 showed that IL-18 stimulates the proangiogenic factor, thrombospondin-1, production through the JNK pathway. The reason for the discrepancy in these results remains unclear, and these discrepant observations prompted us to investigate whether ZD55-IL-18 can downregulate the expression of VEGF and have antiangiogenic effects.…”

Section: Discussionmentioning

confidence: 99%

Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

Zheng

Park

et al. 2009

Cancer Gene Ther

View full text Add to dashboard Cite

It has been shown that interleukin 18 (IL-18) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirusmediated gene transfer of IL-18 could induce strong antitumor activity. A tumor-selective replicating adenovirus expressing IL-18 (ZD55-IL-18) was constructed by insertion of an IL-18 expression cassette into the ZD55 vector, which is based on deletion of the adenoviral E1B 55-kDa gene. It has been shown that ZD55-IL-18 exerted a strong cytopathic effect and significant apoptosis in tumor cells. ZD55-IL-18 significantly decreased vascular endothelial growth factor and CD34 expression in the melanoma cells. Treatment of established tumors with ZD55-IL-18 showed much stronger antitumor activity than that induced by ZD55-EGFP (enhanced green fluorescent protein) or Ad-IL-18. These data indicated that oncolytic adenovirus expressing IL-18 could exert potential antitumor activity through inhibition of angiogenesis and offer a novel approach to melanoma therapy.

show abstract

“…Whatever the case, it should be emphasized that activated JNK has positive and negative effects on urothelial carcinoma development. As to the role of JNK in tumor angiogenesis, Kim and colleagues 53 reported thrombospondin production can be mediated through JNK activation, whereas Ennis and colleagues 54 found JNK inhibition to suppress endothelial cell migration and development of vasculature.…”

Section: Discussionmentioning

confidence: 99%

c-Jun NH2 Terminal Kinase Activation and Decreased Expression of Mitogen-Activated Protein Kinase Phosphatase-1 Play Important Roles in Invasion and Angiogenesis of Urothelial Carcinomas

Shimada

Nakamura

Ishida

et al. 2007

The American Journal of Pathology

View full text Add to dashboard Cite

We here examined whether c-Jun NH 2 terminal kinase (JNK) might be involved in the progression of urothelial carcinomas. In vitro and in vivo invasion assays using Matrigel and chick embryo chorioallantoic membrane approaches showed constitutive activation of JNK to significantly increase two processes, invasion and angiogenesis, in the human urothelial carcinoma cell line kU-7, this being suppressed by a JNK inhibitor, SP600125, or cell-permeable peptides. In addition, we found that mitogen-activated protein kinase phosphatase (

show abstract

IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway

Cited by 61 publications

References 37 publications

Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18

Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18

Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

c-Jun NH2 Terminal Kinase Activation and Decreased Expression of Mitogen-Activated Protein Kinase Phosphatase-1 Play Important Roles in Invasion and Angiogenesis of Urothelial Carcinomas

Contact Info

Product

Resources

About