IL‐17F facilitates prostate cancer cell malignant phenotypes via activation of the PI3K/AKT signalling pathway

Zhu, Xu; Zhao, Shuli; Ma, Xingxin; Cao, Zhigang

doi:10.1111/and.13750

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…The previous study demonstrated that increased expression of thrombomodulin might reduce the migration of cancer cells by restraining PI3K and Akt [ 20 ]. Furthermore,increasing evidence showed that the anticoagulant drugs, such as warfarin and heparin, have antitumor effects both in vivo and in vitro [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with gallbladder carcinoma

et al. 2021

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Background Gallbladder carcinoma (GBC) was the most common malignancy of biliary tract. Patients with malignancies frequently present with activated coagulation pathways, which might potentially related to tumor progression and prognosis. The purpose of the study was to investigate the clinical significance of preoperative serum fibrinogen levels and platelet counts in GBC patients. Methods The preoperative fasting serum fibrinogen levels and platelet counts of 58 patients with GBC were measured by AUV2700 automatic biochemical analyzer, as well as 60 patients with cholesterol polyps and 60 healthy volunteers. Kaplan–Meier survival analysis was applied to show the correction between fibrinogen levels and outcome after surgery. Results The fibrinogen levels of patients with GBC were significantly higher than healthy gallbladder and cholesterol polyp of gallbladder (p < 0.001 and p < 0.001, respectively). In GBC, fibrinogen levels were associated with tumor depth (p = 0.001), lymph node metastasis (p = 0.002), distant metastasis (p < 0.001) and Tumor Node Metastasis (TNM) stage (p < 0.001). The levels in TNM stage IV disease were significantly higher than stage III or stage I + II disease (p = 0.048 and p < 0.001, respectively), and in TNM stage III disease were significantly higher than stage I + II disease (p = 0.002). Furthermore, the overall survival was better in low fibrinogen level group than in high fibrinogen level group (p < 0.001). However, thrombocytosis was not significantly associated with overall survivals (p > 0.05) in multivariate analysis. Conclusions The preoperative serum fibrinogen levels and platelet counts might be reliable biomarkers for the occurance of disease, tumor depth, lymph node metastasis, distant metastasis and advanced TNM stage in patients with GBC. The serum fibrinogen levels might be a prognostic factor to predict outcome for GBC patients suffering from surgery treatment. Anticoagulation therapy might be considered to control cancer progression in future studies.

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Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with gallbladder carcinoma

et al. 2021

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“…Taxifolin inhibits androgen production in Leydig cells, inhibits PCa cell growth, and induces PCa cell apoptosis [ 16 ]. Quercetin blocks AR activity and inhibits PCa development [ 42 ]. Kaempferol significantly inhibits dihydrotestosterone (DHT) AR activation, while reducing downstream targets of AR and ultimately inhibiting PCa cell proliferation, angiogenesis, and invasion [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Mechanism of Action of “Fructus Ligustri Lucidi-Cuscutae Semen” in Prostate Cancer Treatment Using Network Pharmacology and Molecular Docking

Shang

Guo

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the mechanism of action of “Fructus Ligustri Lucidi-Cuscutae Semen” in the treatment of prostate cancer using network pharmacology and molecular docking. Methods. The active ingredients and targets of “Fructus Ligustri Lucidi-Cuscutae Semen” were obtained by searching the TCMSP and DrugBank databases. These were matched and corrected using the UniProt platform. A drug “active ingredient-target” network map was constructed using Cytoscape 3.8.0. Prostate cancer-related targets were acquired from GeneCards, Disgenet, DrugBank, and other databases. The protein-protein interaction (PPI) network between the drug and prostate cancer was constructed with BioGenet; the crossover network of the two targets was extracted derive the key targets of “Fructus Ligustri Lucidi-Cuscutae Semen” for prostate cancer treatment. We used the Metascape platform for GO and KEGG enrichment analysis of the key targets. AutoDockTools1.5.6 and PyMOL software were used to perform molecular docking. Results. We obtained 13 active ingredients, 221 drug targets, 1511 prostate cancer targets (including 221 key targets), and 305 KEGG pathways from “Fructus Ligustri Lucidi-Cuscutae Semen.” Paclitaxel, quercetin, kaempferol, TP53, β-sitosterol, EGFR, and ESR1 in “Fructus Ligustri Lucidi-Cuscutae Semen” showed good docking activity. Conclusion. “Fructus Ligustri Lucidi-Cuscutae Semen” is a valuable clinical guide for the treatment of prostate cancer with multicomponent, multitarget, and multipathway characteristics.

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“…In cancerous prostate samples, IL-17, IL-6, and IL-8 were strongly correlated [ 124 ]. Moreover, a recent study found that IL-17F activated the PI3K/Akt signaling pathway to enhance PCa cell malignant phenotypes, indicating a potential treatment target for PCa [ 125 ]. A Galician single nucleotide polymorphism (SNP) analysis found that the IL-17 gene polymorphism −197G > A increases PCa risk [ 126 ].…”

Section: Proinflammatory Cytokines and CXC Chemokinesmentioning

confidence: 99%

The role of proinflammatory cytokines and CXC chemokines (CXCL1–CXCL16) in the progression of prostate cancer: insights on their therapeutic management

Ullah,

Jiao,

Shen

2024

Cell Mol Biol Lett

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Reproductive cancers are malignancies that develop in the reproductive organs. One of the leading cancers affecting the male reproductive system on a global scale is prostate cancer (PCa). The negative consequences of PCa metastases endure and are severe, significantly affecting mortality and life quality for those who are affected. The association between inflammation and PCa has captured interest for a while. Inflammatory cells, cytokines, CXC chemokines, signaling pathways, and other elements make up the tumor microenvironment (TME), which is characterized by inflammation. Inflammatory cytokines and CXC chemokines are especially crucial for PCa development and prognosis. Cytokines (interleukins) and CXC chemokines such as IL-1, IL-6, IL-7, IL-17, TGF-β, TNF-α, CXCL1–CXCL6, and CXCL8–CXCL16 are thought to be responsible for the pleiotropic effects of PCa, which include inflammation, progression, angiogenesis, leukocyte infiltration in advanced PCa, and therapeutic resistance. The inflammatory cytokine and CXC chemokines systems are also promising candidates for PCa suppression and immunotherapy. Therefore, the purpose of this work is to provide insight on how the spectra of inflammatory cytokines and CXC chemokines evolve as PCa develops and spreads. We also discussed recent developments in our awareness of the diverse molecular signaling pathways of these circulating cytokines and CXC chemokines, as well as their associated receptors, which may one day serve as PCa-targeted therapies. Moreover, the current status and potential of theranostic PCa therapies based on cytokines, CXC chemokines, and CXC receptors (CXCRs) are examined.

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IL‐17F facilitates prostate cancer cell malignant phenotypes via activation of the PI3K/AKT signalling pathway

Cited by 5 publications

References 26 publications

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with gallbladder carcinoma

The clinical significance of preoperative serum fibrinogen levels and platelet counts in patients with gallbladder carcinoma

Assessing the Mechanism of Action of “Fructus Ligustri Lucidi-Cuscutae Semen” in Prostate Cancer Treatment Using Network Pharmacology and Molecular Docking

The role of proinflammatory cytokines and CXC chemokines (CXCL1–CXCL16) in the progression of prostate cancer: insights on their therapeutic management

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