IL-17B: A new area of study in the IL-17 family

Bie, Qingli; Jin, Cao; Zhang, Bin; Dong, Haixin

doi:10.1016/j.molimm.2017.07.004

Cited by 60 publications

(54 citation statements)

References 47 publications

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“…We found that a critical gene IL17RB was upregulated in catagen SHF compared with telogen SHF. IL17 superfamily is a relatively new family of cytokines, which consists of 6 ligands and can bind 5 receptor subtypes[ 21 ]. According to recent researches and our transcriptome data, we predicted that IL17RB might play a role in the development of SHF because it acts as a mediate signaling in many other physiological functions[ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis reveals critical genes for the hair follicle of Inner Mongolia cashmere goat from catagen to telogen

Fan

Qiao

et al. 2018

PLoS ONE

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There are two main types of hair follicle in Inner Mongolia Cashmere goats, the primary hair follicle (PHF) producing hair fibers and the secondary hair follicle (SHF) producing cashmere fibers. Of both fibers from cashmere-bearing goats in Aerbasi, Inner Mongolia, the timing of cyclical phases for the cashmere have been well clarified but hair fibers have been less noticeable. Herein, we evaluated transcriptome of PHF and SHF from the same three goats in Aerbasi at the catagen- and telogen phase of cashmere growth. We totally found 1977 DEGs between PHFs at the telogen and catagen phases of SHF, 1199 DEGs between telogen- and catagen SHF, 2629 DEGs between PHF at the catagen phase of SHF and catagen SHF, and 755 DEGs between PHF at the telogen phase of SHF and telogen SHF. By analyzing gene functions based on GO and KEGG database, we found that the DEGs have functions in muscle contraction and muscle filament sliding between catagen- and telogen SHF, indicating that arrector pilli muscles might play a role on the transition from catagen to telogen. Moreover, considering that the enriched GO and KEGG categories of the DEGs between PHF and SHF, we suggested that part of PHF might rest in their own anagen phase when SHF are at catagen, but PHF might enter into the telogen phase at SHF’s telogen. Finally, we highly recommended the several potential genes acting as the regulators of the transition between growth phases including IL17RB and eight members of ZNF. These results provide insight into molecular mechanisms on the transition of SHF from catagen to telogen together with PHF’s growth situation at SHF’s catagen and telogen in Inner Mongolia Cashmere goats.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis reveals critical genes for the hair follicle of Inner Mongolia cashmere goat from catagen to telogen

Fan

Qiao

et al. 2018

PLoS ONE

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“…Studies have shown that IL-17A represents the prototype member of the IL-17 cytokine family and is mainly produced by Th17 cells. Unlike IL-17A, IL-17B is widely expressed in various tissue types and its biological function is associated with pathologies, particularly to tumors ( 81 ).…”

Section: Cells Producing Il-17mentioning

confidence: 99%

“…It has been also observed that the signal triggered by the interaction of IL-17B with its receptor IL-17RB positively regulates Mesenchymal stem cells (MSCs) through the activation of the AKT/β-catenin pathway in gastric cancer. This suggests that IL-17B increases the progression of gastric cancer by the activation of MSCs ( 81 ).…”

Section: Cells Expressing Receptors For the Il-17 Familymentioning

confidence: 99%

Th17 response in patients with cervical cancer (Review)

et al. 2018

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Persistent infection by high-risk human papillomavirus (HR-HPV) is the main risk factor for uterine cervical cancer (UCC). However, viral infection alone is not sufficient for the development and progression of premalignant cervical lesions for cancer. In previous years it has been suggested that the adaptive immune response triggered by the differentiation of naïve helper T cells in Th17 cells may serve an important role in disease development. It has been hypothesized that Th17 cells may be involved in the promotion of UCC, as high levels of interleukin 17 (IL17) expression have been detected in the mucosa of the uterine cervix of patients affected by the disease. However, the role of Th17 cells in the tumor development and progression remains unclear. It is believed that the immune response of the Th17 type during persistent infection of the genital tract with HR-HPV triggers chronic inflammation with a long duration with the production of IL17 and other pro-inflammatory cytokines, creating a favorable environment for tumor development. These cytokines are produced by immune system cells in addition to tumor cells and appear to function by modulating the host immune system, resulting in an immunosuppressive response as opposed to inducing an effective protective immune response, thus contributing to the growth and progression of the tumor. In the present review, the latest advances are presented about the function of Th17 cells and the cytokines produced by them in the development and progression of UCC.

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“…The same study also showed that neutralization of IL-17B ameliorated disease. Relatively little is known regarding the role in RA of IL-17B, which has 29% homology with IL-17A (Bie et al, 2017). One study showed that IL-17B mRNA and protein is expressed in RA synovial tissue, where it is produced by neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-17 in rheumatoid arthritis: Trials and tribulations

Taams

2020

Journal of Experimental Medicine

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Interleukin-17A (IL-17A) is a pro-inflammatory cytokine with well-characterized biological effects on stromal cell activation, angiogenesis, and osteoclastogenesis. The presence of this cytokine in the inflamed joints of patients with rheumatoid arthritis (RA), together with compelling data from in vitro and experimental arthritis models demonstrating its pro-inflammatory effects, made this cytokine a strong candidate for therapeutic targeting. Clinical trials, however, have shown relatively modest success in RA as compared with other indications. Guided by recent insights in IL-17 biology, this review aims to explore possible reasons for the limited clinical efficacy of IL-17A blockade in RA, and what we can learn from these results going forward.

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IL-17B: A new area of study in the IL-17 family

Cited by 60 publications

References 47 publications

Transcriptomic analysis reveals critical genes for the hair follicle of Inner Mongolia cashmere goat from catagen to telogen

Transcriptomic analysis reveals critical genes for the hair follicle of Inner Mongolia cashmere goat from catagen to telogen

Th17 response in patients with cervical cancer (Review)

Interleukin-17 in rheumatoid arthritis: Trials and tribulations

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