IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia

Wolf, Lisa; Sapich, Sandra; Honecker, Anja; Bischoff, Markus; Daum, Nicole; Cm, Lehr; Seiler, Frederik; Bals, Robert; Beißwenger, Christoph

doi:10.1055/s-0037-1598419

Cited by 7 publications

(7 citation statements)

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“…Interestingly, Wolf et al. showed that in mice, Pseudomonas aeruginosa ‐induced IL‐17C expression in lung epithelial cells by a IL‐17A-dependent mechanism, thus demonstrating a network within the family of IL-17 cytokines that regulates each other expression ( 29 ).…”

Section: Cytokines Of the Il-17 Family Other Than Il-17a In Health Anmentioning

confidence: 99%

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer

et al. 2020

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Section: Cytokines Of the Il-17 Family Other Than Il-17a In Health Anmentioning

confidence: 99%

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer

et al. 2020

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“…IL‐17RE‐deficient mice show decreased production of AMPs after C. rodentium infection, which results in increased bacterial burdens and decreased survival rates , clearly demonstrating the protective role of the IL‐17C–IL‐17RA/IL‐17RE axis against these infections. C. albicans , S. aureus , H. pylori , P. aeruginosa and herpes simplex virus also induce IL‐17C production by epithelial cells. Interestingly, P. aeruginosa‐ induced IL‐17C expression by lung epithelial cells in mice with pulmonary infections depends on the presence of IL‐17A , suggesting the existence of a network of IL‐17 family cytokines that regulate expression of each of its members.…”

Section: Role Of Non‐hematopoietic Cell‐derived Il‐17 Family Cytokinementioning

confidence: 99%

Interleukin‐17 family cytokines in protective immunity against infections: role of hematopoietic cell‐derived and non‐hematopoietic cell‐derived interleukin‐17s

Matsuzaki

Umemura

2018

Microbiology and Immunology

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Interleukin-17 family cytokines, consisting of six members, participate in immune response in infections and autoimmune and inflammatory diseases. The prototype cytokine of the family, IL-17A, was originally identified from CD4þ T cells which are now termed Th17 cells. Later, IL-17A-producing cells were expanded to include various hematopoietic cells, namely CD8þ T cells (Tc17), invariant NKT cells, gd T cells, non-T non-B lymphocytes (termed type 3 innate lymphoid cells) and neutrophils. Some IL-17 family cytokines other than IL-17A are also expressed by CD4þ T cells: IL-17E by Th2 cells and IL-17F by Th17 cells. IL-17A and IL-17F induce expression of pro-inflammatory cytokines to induce inflammation and anti-microbial peptides to kill pathogens, whereas IL-17E induces allergic inflammation. However, the functions of other IL-17 family cytokines have been unclear. Recent studies have shown that IL-17B and IL-17C are expressed by epithelial rather than hematopoietic cells. Interestingly, expression of IL-17E and IL-17F by epithelial cells has also been reported and epithelial cell-derived IL-17 family cytokines shown to play important roles in immune responses to infections at epithelial sites. In this review, we summarize current information on hematopoietic cell-derived IL-17A and non-hematopoietic cell-derived IL-17B, IL-17C, IL-17D, IL-17E and IL-17F in infections and propose functional differences between these two categories of IL-17 family cytokines.

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“…An early study showed that topical treatment with polyclonal Abs to IL-17 resulted in significant reductions in corneal pathology and lowered bacterial counts postinfection with six different laboratory or clinical P. aeruginosa strains, including both invasive and cytotoxic strains, and ICAM1 was suggested as a downstream molecule (47). In the airway mucosa, IL-17A promotes inflammation and impairs host defenses in acute and chronic Pseudomonas lung infection (48,49). In biofilm bacteria-infected patients, the IL-17 levels in the lavage fluids were significantly higher than that in nonbiofilm bacteria-infected patients; the elevated IL-17 was attributed to chronic injuries caused by biofilm infections (50).…”

Section: Discussionmentioning

confidence: 99%

IL-17 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas

Gao

Dai

et al. 2020

The Journal of Immunology

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The aim of this study was to elucidate the expression and functions of IL-17 in C57BL/6 mouse corneas in response to Pseudomonas aeruginosa infection. We found that P. aeruginosa infection induced and increased signaling of IL-23/23R/17/17R in mouse corneas. Targeting IL-17A or the IL-17A-specific receptor IL-17RA/IL-17RC with neutralizing Abs resulted in a significant decrease in the severity of P. aeruginosa keratitis, including a decrease in bacterial burden and polymorphonuclear leukocyte infiltration. IL-17A-signaling blockade also significantly reduced the expression of the proinflammatory cytokines L-1b, IL-24, and MMP-13 and increased the expression of the anti-inflammatory cytokine IL-1RA in mouse corneal epithelium. The presence of mouse IL-17A exacerbated P. aeruginosa-mediated tissue destruction. A cytokine protein array revealed that the expression of osteoprotegerin (OPG) was regulated by IL-17A, and OPG neutralization also resulted in a decrease in the severity of P. aeruginosa keratitis. Although both IL-17 and OPG affected the balanced expression of IL-1b and IL-1RA, only IL-17 inhibited the expression of TH2 cytokines. Taken together, our results revealed that IL-17A, along with its downstream factor OPG, plays a detrimental role in the pathogenesis of P. aeruginosa keratitis. Targeting IL-17A and/or the OPG/RANKL/RANK/TRAIL system is a potential therapeutic strategy in controlling the outcome of P. aeruginosa keratitis, which was demonstrated by concurrent topical application of IL-17A-neutralizing Ab and ciprofloxacin in B6 mice.

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IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia

Cited by 7 publications

References 0 publications

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer

Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer

Interleukin‐17 family cytokines in protective immunity against infections: role of hematopoietic cell‐derived and non‐hematopoietic cell‐derived interleukin‐17s

IL-17 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas

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