IL-17A gene polymorphism at position G197A and systemic lupus erythematosus

Systemic Lupus erythematosus (SLE) is a worldwide autoimmune disease with different presentations. Genetic and environmental factors like infection and ultraviolet light are supposed to be responsible for the development of SLE. Disturbance in cytokines production may be involved in SLE pathogenesis. In this case-control study, we investigate the interleukin-17F (IL-17F) gene polymorphism (7488T/C, rs763780) in Egyptian SLE patients using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There were no significant changes when both genotypes and alleles for patients and controls were compared with each other. According to the results, no association between the IL-17F gene polymorphism (7488T/C, rs763780) and SLE.

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“…Our findings were in agreement with Sharifzadeh et al, (2018). His case-control study involved 102 SLE patients and 141 healthy control subjects.…”

Section: Discussionsupporting

confidence: 92%

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

El-Sherbini

AbdAlRaouf²,

El‐Masry³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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“…By contrast, Sharifzade et al. 27 reported that the IL-17 rs2275913 A allele may be protective against SLE in an adult Iranian population. Ethnic background or gene–environmental interplay as well as variations in studied age group and cohort size may account for this discrepancy.…”

Section: Discussionmentioning

confidence: 89%

“…Recently, the IL-17A polymorphisms have been linked with human autoimmune disorders such as rheumatoid arthritis, autoimmune thyroid disease, ulcerative colitis and adult-onset SLE. 23–26 Only a few studies have examined the association between the IL-17 SNPs and susceptibility to adult-onset SLE and LN, 26 , 27 with conflicting results.…”

Section: Discussionmentioning

confidence: 99%

Association of interleukin-17A gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multi-centre study

Elkoumi

Allah

Mohamed

et al. 2020

Lupus

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Background Recently, the interleukin-17A ( IL-17A) gene has emerged as a potential candidate gene for autoimmune disorders, including systemic lupus erythematosus (SLE). Objectives This study aimed to investigate whether IL-17A polymorphisms at rs2275913 G/A, rs8193036 C/T and rs3748067 C/T could be susceptibility markers for juvenile-onset SLE (JSLE) and lupus nephritis (LN) in Egyptian children and adolescents. Methods In this multi-centre study, we genotyped 320 patients diagnosed with JSLE and 320 matched control children for three IL-17A polymorphisms at rs2275913 G/A, rs8193036 C/T and rs3748067 C/T using TaqMan probe-based real-time polymerase chain reaction. Meanwhile, IL-17A serum levels were assessed using ELISA. Results The IL-17 rs2275913 A/A genotype and A allele were more represented in JSLE patients compared to the control group (21% vs. 7%, odds ratio (OR) = 3.8, 95% confidence interval (CI) 1.78–5.5, p = 0.001, pBonf = 0.003 for the A/A genotype; 37% vs. 29%, OR = 1.4, 95% CI 1.11–1.8, p = 0.003, pBonf = 0.009 for the A allele. No significant difference was found for IL-17 rs8193036 and rs3748067 single nucleotide polymorphisms (SNPs) in genotype distribution or allele frequencies ( p>0.05). Patients carrying the IL-17 rs2275913 A/A genotype and A allele were more likely to develop LN (OR = 5.64, 95% CI 2.39–13.77, pBonf = 0.001 for the A/A genotype; OR = 2.73, 95% CI 1.84–4.07, pBonf = 0.02 for the A allele). Conclusion The IL-17 rs2275913 A allele and A/A genotype were associated with high IL-17 serum levels and may contribute to susceptibility to JSLE and the development of LN in Egyptian children and adolescents. However, no significant association was evident between the studied IL-17A SNPs and other clinical phenotypes, disease activity scores or laboratory profile of JSLE.

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“…27 In contrast, it offered marginal protection against SLE development in an Iranian cohort. 28 Furthermore, there was no significant association between IL-17A rs2275913 polymorphism and SLE in two independent studies from Mexico 29 and the Bulgarian population. 30 One of the key reasons for these inconsistencies is the use of smaller sample sizes, which results in a decreased power of the study to detect any possible genetic link.…”

Section: Introductionmentioning

confidence: 95%

Interleukin 17A rs2275913 polymorphism is associated with susceptibility to systemic lupus erythematosus: A meta and trial sequential analysis

Padhi

Sarangi

Nayak

et al. 2022

Lupus

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Background The role of cytokines in the development of systemic lupus erythematosus (SLE) has received much attention. Interleukin-17 A upregulates several inflammation-related genes and is thought to have a crucial role in SLE development. The susceptibility to SLE development has been linked to functional genetic variations of the IL-17A gene; nevertheless, the findings have been conflicting. We conducted a meta-analysis that included previously published reports to establish a definitive conclusion on the role of the IL-17A rs2275913 polymorphism in SLE propensity. Materials and Methods The PubMed, Google Scholar, and Scopus databases were used to find eligible published articles. All analyses were conducted using Comprehensive Meta-analysis V3.1. Funnel plots and Egger’s regression analysis were used to assess publication bias. Q statistics and I2 test explored the heterogeneity among the included studies. Combined odds ratio, 95% confidence interval were calculated for each comparison model. Results Based on the inclusion and exclusion criteria, a total of four reports, comprising of 608 SLE patients and 815 healthy controls, were considered for the present meta-analysis. The homozygous comparison (AA vs. GG: combined odds ratio= 2.046, p = 0.005) and recessive genetic model (AA vs. GG+GA: combined odds ratio=1.901, p = 0.010) analysis revealed a significant association of rs2275913 with susceptibility to the development of SLE. However, other genetic comparisons (A vs. G, GA vs. GG, AA+GA vs. GG) failed to demonstrate such association. Furthermore, trial sequential analysis revealed a sufficient number of studies, including enough cases and controls that have already been considered to conclude the role of IL17-A rs2275913 polymorphism in SLE. Conclusions IL-17A rs2275913 polymorphism is associated with susceptibility to SLE development.

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IL-17A gene polymorphism at position G197A and systemic lupus erythematosus

Cited by 9 publications

References 16 publications

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

Association of interleukin-17A gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multi-centre study

Interleukin 17A rs2275913 polymorphism is associated with susceptibility to systemic lupus erythematosus: A meta and trial sequential analysis

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