2019
DOI: 10.1016/j.bbi.2019.07.026
|View full text |Cite
|
Sign up to set email alerts
|

IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

3
79
1

Year Published

2019
2019
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 103 publications
(83 citation statements)
references
References 53 publications
3
79
1
Order By: Relevance
“…We therefore propose a dual role for IL-17 in physiological versus pathological conditions. Whereas, as shown here, the steady-state (and microbiotaindependent) production of IL-17 by meningeal γδ T cells promotes learning and memory, its exacerbated production (by γδ but also recruited CD4 + T cells) upon inflammation contributes to the pathogenesis of neuroinflammation and likely also to neurodegeneration, as recently suggested for Parkinson's disease (58,59).…”
Section: Discussionsupporting
confidence: 66%
“…We therefore propose a dual role for IL-17 in physiological versus pathological conditions. Whereas, as shown here, the steady-state (and microbiotaindependent) production of IL-17 by meningeal γδ T cells promotes learning and memory, its exacerbated production (by γδ but also recruited CD4 + T cells) upon inflammation contributes to the pathogenesis of neuroinflammation and likely also to neurodegeneration, as recently suggested for Parkinson's disease (58,59).…”
Section: Discussionsupporting
confidence: 66%
“…and an increased number of Th17 cells in their peripheral blood [4][5][6][7][8]. Similar findings were found in mice intoxicated with MPTP [11][12][13][14]. The increased number of Th17 cells in the blood was correlated with augmented cell death of human induced pluripotent stem cell (hiPSC)-derived midbrain neurons from PD patients [10].…”
Section: An Increased Number Of T Lymphocytes Have Been Found In Postsupporting
confidence: 61%
“…Growing evidence has indicated that T helper cells might contribute to the cascade of neuroinflammation by breaking the balance of peripheral T helper 17 (Thl7) cells and regulatory T (Treg) cells [3][4][5][6][7][8][9]. IL-17-producing Th17 cells play a pivotal role in neuronal cell death, whereas Treg cells attenuate Th17 cells mediated nigrostriatal dopaminergic neuronal cell death [10][11][12]. As a result, imbalance between Th17 and Treg cells leads to neurodegeneration in the substantia nigra.…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations