IL-17A control CNS inflammatory disease by regulating Treg cells through modulation of gut microbiota in HLA class-II transgenic mice model of multiple sclerosis (MS)
Abstract:Despite extensive studies on IL-17A in MS and its animal model EAE, the role of IL-17 in disease development and maintenance is unclear. We have previously established proteolipid protein-(PLP)91–110 induce EAE model in HLA-DR3 transgenic mice. In the present study, we investigated the role of IL-17A in disease development and severity utilizing HLA-DR3 transgenic mice lacking IL-17A (IL-17A−/−). We observed that HLA-DR3.IL17A−/− mice develop milder EAE than HLA-DR3 mice suggesting that IL17 is redundant for t… Show more
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