IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome

Carvalho, Camila Nunes; Carmo, Rodrigo Feliciano do; Duarte, Angela; Carvalho, Alessandra Albuquerque Tavares; Leão, Jair Carneiro; Gueiros, Luiz Alcino Monteiro

doi:10.1007/s00784-015-1540-2

Cited by 18 publications

(23 citation statements)

References 39 publications

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“…This result confirmed a previous report in the Tunisian population [ 26 ]. Again, most of published studies performed in Algerian [ 27 ], Polish [ 28 , 29 ], Brazilian [ 30 ] and Chinese [ 31 ] populations emphasized the lack of association between the IL-17A rs2275913 and RA risk. Nevertheless, two studies performed in Norwegian [ 32 ] and Brazilian [ 33 ] reported that the rs2275913 polymorphism increased risk of RA.…”

Section: Discussionmentioning

confidence: 99%

IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis

et al. 2018

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BackgroundInterleukin-17 (IL-17), a cytokine mainly secreted by Th17 cells, seems to play a significant role in the pathogenesis of rheumatoid arthritis (RA). Functional genetic polymorphisms in IL-17 and its receptor genes can influence either qualitatively or quantitatively their functions. Therefore, we aimed to study the impact of IL17-A and IL17RC polymorphisms on plasma level of IL-17 and RA susceptibility and severity.MethodsIn this context, IL-17A*rs2275913 and IL-17RC*rs708567 polymorphisms were investigated together with the quantification of IL17 plasma level in 115 RA patients and 91 healthy control subjects matched in age, sex and ethnic origin.ResultsThere were no statistically significant associations between IL-17A and IL-17RC studied polymorphisms and RA susceptibility. In contrast, IL-17A plasma levels were significantly higher in patients (55.07 pg/ml) comparatively to controls (4.75 pg/ml), p<10E-12. A ROC curve was used to evaluate the performance of plasma IL-17 in detecting RA. Given 100% specificity, the highest sensitivity of plasma IL-17A was 61.7% at a cut-off value of 18.25 pg/ml; p < 10E-21, CI = [0.849–0.939]. Analytic results showed that the IgM-rheumatoid factor and anti-CCP antibodies were significantly less frequent in patients with the IL-17RC*A/A genotype than those carrying *G/G and *G/A genotypes; p = 0.013 and p = 0.015, respectively. Otherwise, IL-17 plasma levels’ analysis showed a significant association with the activity of RA (DAS28≥5.1 = 74.71 pg/ml vs. DAS28<5.1 = 11.96 pg/ml), p<10E-6.ConclusionIL-17A*rs2275913 (G/A) and IL-17RC*rs708567 (G/A) polymorphisms did not seem to influence RA susceptibility in Tunisian population. This result agrees with those reported previously. Plasma IL-17A level seems to be predictive of severe RA occurrence.

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Section: Discussionmentioning

confidence: 99%

IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis

et al. 2018

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“…We analyzed the controls of each study for the fitness in the HWE. The study of Carvalho et al 17 was deviated from HWE. In addition, the HWE of Louahchi et al 19 was not available for the lack of genotype frequency data.…”

Section: Resultsmentioning

confidence: 90%

“…Finally, seven studies including 1,409 RA patients and 1,303 controls were eligible for the present study. [13][14][15][16][17][18][19] The flow chart of the literature research and study selection is shown in Figure 1. Among the included studies, all seven investigated the correlation between 7488A/G and RA susceptibility, but only four (containing 1,093 cases and 969 controls) researched 7383A/G and RA risk.…”

Section: Resultsmentioning

confidence: 99%

Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis

Chen

Yang

et al. 2019

Arch Rheumatol

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Objectives: This meta-analysis aims to summarize and estimate the relationship between rheumatoid arthritis (RA) susceptibility and two polymorphisms of interleukin-17F (IL-17F) 7488A/G and 7383A/G. Materials and methods: PubMed, Embase and Web of Science were searched up to 01 July 2017. Case-control studies with genotype frequencies data for 7488A/G and 7383A/G were included. The pooled effects were calculated by fixed-effect model or random effects model. Results: A total of seven publications with 1,409 RA patients and 1,303 controls were included in the present meta-analysis. The results indicated that 7488A/G was significantly associated with increased susceptibility to RA (GA vs. AA: odds ratio [OR]=1.43, 95% confidence interval [

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“…Although there is a clear pattern of Th17 response in inflammatory and autoimmune diseases, the relevance of IL17 polymorphism varies according to the disease. We have previously demonstrated a lack of association between IL17A SNP, rheumatoid arthritis and secondary Sjögren's syndrome (Carvalho et al., ) in a study with 206 individuals, but a weak association was demonstrated in a larger sample (Nordang et al., ). In ankylosing spondylitis, a SNP in the promoter region of IL17RA was associated with an elevated risk, with a stronger association in individuals with severe forms (Vidal‐Castiñeira et al., ).…”

Section: Discussionmentioning

confidence: 87%

IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus

et al. 2017

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IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome

Abstract: A better understanding of the pathogenesis of SS is demanded to an adequate treatment as well as to the development of new management strategies.

Cited by 18 publications

References 39 publications

IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis

IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis

Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis

IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus

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