IL-17 in osteoarthritis: A narrative review

Abstract

Osteoarthritis (OA) is a painful joint disease that is common among the middle-aged and elderly populations, with an increasing prevalence. Therapeutic options for OA are limited, and the pathogenic mechanism of OA remains unclear. The roles of cytokines and signaling pathways in the development of OA is a current research hot spot. Interleukin (IL)-17 is a pleiotropic inflammatory cytokine produced mainly by T helper 17 cells that has established roles in host defense, tissue repair, lymphoid tissue metabolism, tumor progression, and pathological processes of immune diseases, and studies in recent years have identified an important role for IL-17 in the progression of OA. This narrative review focuses on the mechanisms by which IL-17 contributes to articular cartilage degeneration and synovial inflammation in OA and discusses how IL-17 and the IL-17 signaling pathway affect the pathological process of OA. Additionally, therapeutic targets that have been proposed in recent years based on IL-17 and its pathway in OA are summarized as well as recent advances in the study of IL-17 pathway inhibitors and the potential challenges of their use for OA treatment.

Identification and validation of novel characteristic genes based on multi-tissue osteoarthritis

“…These pathways and functions were highly consistent with those of the DEGs, demonstrating the representative value of the identi ed hub genes. Additionally, these pathways and enrichments are in line with previous studies 19,[40][41][42] .…”

Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

“…The results of KEGG analysis showed that RJNTF could treat KOA by interfering with multiple signaling pathways such as NF-κB, apoptosis, HIF-1 signaling pathway, JAT-STAT signaling pathway and IL-17 signaling pathway ( Fig. 2B ) ( 31 – 34 ). Based on the results of a large number of previous studies showing that the PARP1/AIF pathway was closely related to apoptosis ( 35 – 37 ), while the results of network pharmacology indicated that the treatment of KOA by RJNTF was related to the PARP1 apoptotic pathway; however, there are no studies assessing the relationship between the PARP1/AIF pathway and apoptosis of chondrocytes.…”

Cartilage decellularized matrix hydrogel loaded with protocatechualdehyde for targeted epiphycan treatment of osteoarthritis

“…The IL-17 signaling pathway has been repeatedly reported in relation to OA. The IL-17 family consists of six cytokines (IL-17A to F), with IL-17A being the most extensively studied and considered the most influential [ 15 , 17 , 31 , 32 ]. Studies have shown that the levels of IL-17A in the serum and synovial fluid of OA patients are higher than those in healthy individuals and are positively correlated with measures of pain, functionality, and disease severity [ 18 , 33 ].…”

“…The IL-17 signaling pathway has been repeatedly reported to be related to OA. IL-17 is a family of six cytokines (IL-17A-F), with IL-17A being the most studied and significant [ 17 , 31 , 32 , 42 ]. Studies have shown that the extracellular matrix (ECM) regulates the activation state of cells by blocking or facilitating the binding of cytokines to cell surface receptors.…”