IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum

Brabec, Tomáš; Vobořil, Matouš; Schierová, Dagmar; Valter, Evgeny; Šplíchalová, Iva; Dobeš, Jan; Březina, Jiří; Dobešová, Martina; Aidarova, Aigerim; Jakubec, Martin; Manning, Jasper; Blumberg, Richard S.; Waissman, Ari; Kolář, Michal; Kubovčiak, Jan; Šrůtková, Dagmar; Hudcovic, Tomáš; Schwarzer, Martin; Froňková, Eva; Pinkasová, Tereza; Jabandžiev, Petr; Filipp, Dominik

doi:10.1016/j.mucimm.2023.01.005

Cited by 4 publications

(1 citation statement)

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“…101 In the ileitis of mice, Brabec et al found that when the IL-17 receptor is defective, the ileum of mice not only shows decreased antibacterial ability characterized by decreased production of alpha-defensin, but also unfolds significantly reduced diversity of the microbiota. 102 This suggests that IL-17 may maintain the ecological balance of gut microbiota by promoting the expression of antimicrobial peptides.…”

Section: Il-17s Are Involved In Barrier Surface Protec Ti Onmentioning

confidence: 99%

Physiological roles of human interleukin‐17 family

Liu,

Ouyang,

You

et al. 2023

Experimental Dermatology

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Interleukin‐17 s (IL‐17s) are well‐known proinflammatory cytokines, and their antagonists perform excellently in the treatment of inflammatory skin diseases such as psoriasis. However, their physiological functions have not been given sufficient attention by clinicians. IL‐17s can protect the host from extracellular pathogens, maintain epithelial integrity, regulate cognitive processes and modulate adipocyte activity through distinct mechanisms. Here, we present a systematic review concerning the physiological functions of IL‐17s. Our goal is not to negate the therapeutic effect of IL‐17 antagonists, but to ensure their safe use and reasonably explain the possible adverse events that may occur in their application.

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Section: Il-17s Are Involved In Barrier Surface Protec Ti Onmentioning

confidence: 99%