IL-17 Cytokines and Chronic Lung Diseases

Ritzmann, Felix; Lunding, Lars; Bals, Robert; Wegmann, Michael; Beißwenger, Christoph

doi:10.3390/cells11142132

Cited by 50 publications

(25 citation statements)

References 149 publications

(206 reference statements)

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“…Multiple signaling pathways contribute to the development of pulmonary fibrosis as the IL-17 signaling pathway plays a direct or indirect role [22][23][24] . Interleukin 17 (IL-17) is a cytokine mainly derived from Th17 cells.…”

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confidence: 99%

“…After IL-17 is attached to the receptor, it exerts biological activity by activating the mitogenic-activated protein kinase 18,19 . The stimulation of IL-17 signaling pathway promotes the inflammation and fibrosis in lung [20][21][22][23][24] . One study reported 25 that molecular, immunohistochemical, and flow cytometric analyses of human and mouse specimens determine the immune response before collagen deposition.…”

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confidence: 99%

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RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

Zhang

Luo

Yuan

et al. 2023

Sci Rep

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Pulmonary fibrosis (PF) is a special type of pulmonary parenchymal disease, with chronic, progressive, fibrosis, and high mortality. There is a lack of safe, effective, and affordable treatment methods. Qilongtian (QLT) is a traditional Chinese prescription that is composed of Panax notoginseng, Earthworm, and Rhodiola, and shows the remarkable clinical curative effect of PF. However, the mechanism of QLT remains to be clarified. Therefore, we studied the effectivity of QLT in treating Bleomycin (BLM) induced PF mice. 36 C57BL/6 J mice were randomized into the control group, the model group, the low-, medium- and high-dose QLT group, and Pirfenidone group. After establishing a model of pulmonary fibrosis in mice, the control and model groups were infused with a normal saline solution, and the delivery group was infused with QLT. Pulmonary function in the mice from each group was detected. Pulmonary tissue morphologies and collagen deposition were stained by HE and Masson. The content of hydroxyproline (HYP) was detected by alkaline hydrolysis and the mRNA and protein expression of related genes in pulmonary tissues were detected by using q-PCR, ELISA, and Western blot. Our studies have shown that QLT significantly reduced the inflammatory injury, hydroxy-proline content, and collagen deposition of pulmonary tissue in BLM-induced PF mice and down-regulated the cytokine related to inflammation and fibrosis and PF expression on the mRNA and protein level in PF mice. To identify the mechanism of QLT, the Transcriptome was measured and the IL-17 signal pathway was screened out for further research. Further studies indicated that QLT reduced the mRNAs and protein levels of interleukin 17 (IL-17), c–c motif chemokine ligand 12 (CCL12), c-x-c motif chemokine ligand 5 (CXCL5), fos-like antigen 1 (FOSL1), matrix metalloproteinase-9 (MMP9), and amphiregulin (AREG), which are inflammation and fibrosis-related genes in the IL-17 signal pathway. The results indicated that the potential mechanism for QLT in the prevention of PF progression was by inhibiting inflammation resulting in the IL-17 signal pathway. Our study provides the novel scientific basis of QLT and represents new therapeutics for PF in clinical.

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confidence: 99%

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confidence: 99%

RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

Zhang

Luo

Yuan

et al. 2023

Sci Rep

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“…In our study, plasma IL-17 was positively linear correlations with white cell count and neutrophil cell count. The reason may be related to the recruitment and activation of neutrophils by IL-17, which can effectively promote airway inflammation ( Ritzmann et al., 2022 ). The bronchiectasis severity index (BSI) was used to evaluate the severity of bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis values of Dectin-1 and IL-17 levels in plasma for invasive pulmonary aspergillosis in bronchiectasis

Li²,

Cao³

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundAmong immunocompetent patients, patients with bronchiectasis are considered to be a high-risk group for invasive pulmonary aspergillosis (IPA). Early diagnosis and treatment can improve the prognosis of patients.ObjectivesWe aimed to investigate the diagnostic value of Dectin-1 and IL-17 for diagnosing IPA with bronchiectasis.MethodsWe retrospectively collected data on patients with bronchiectasis who had been hospitalized in the Third Affiliated Hospital of Soochow University between September 2018 to December 2021. Dectin-1, IL-17 and GM were measured by enzyme-linked immunosorbent assays.ResultsA total of 129 patients were analyzed in the study, of whom 33 had proven or probable IPA with bronchiectasis. The remaining 96 patients served as controls. The plasma Dectin-1 and IL-17 levels in the IPA group were significantly higher than that in the control group (P=0.005; P<0.001). The plasma GM, BALF GM, plasma Dectin-1 and IL-17 assays had sensitivities of 39.4%, 62.5%, 69.7% and 78.8%, respectively, and specificities of 89.2%, 91.5%, 72.9% and 71.9%, respectively. The sensitivity of Dectin-1 and IL-17 in plasma was higher than that in plasma and BALF GM. while the specificity is lower than that of plasma and BALF GM. The diagnostic sensitivity and specificity of plasma GM combined with IL-17 for IPA in bronchiectasis were greater than 80%. The combination of plasma GM and IL-17 can improve the sensitivity of the GM test, but does not reduce the diagnostic specificity. The plasma Dectin-1 and IL-17 showed positive linear correlations with the bronchiectasis severity Index (BSI) score in linear regression.ConclusionsPlasma Dectin-1 and IL-17 levels were significantly higher in bronchiectasis patients with IPA. The sensitivity of Dectin-1 and IL-17 was superior to that of GM for the diagnosis of IPA in patients with bronchiectasis. The combination of GM and IL-17 in plasma is helpful for the diagnosis of IPA in bronchiectasis patients who cannot tolerate invasive procedures.

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“…Accordingly, 1,25-(OH)2D3 can effectively prevent Thl7 cells from secreting IL-17 (23). In stable COPD patients, IL-17 was expressed in the bronchial mucosa at a higher level than in the control group, and Th17 was crucial to the emergence and progression of chronic inflammation in COPD (24). 1,25-(OH)2D3 can greatly reduce Th17 generation, which is advantageous for disorders caused by T cell-mediated immunity (25).…”

Section: Vitamin D and Immune Regulationmentioning

confidence: 97%

Vitamin D and Chronic Obstructive Pulmonary Disease

González-Herrera

Ruiz-León

2022

Sci Insights

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Chronic obstructive pulmonary disease (COPD) is one of the most prevalent diseases of the respiratory system in the elderly, and it poses a grave threat to the survival and quality of life. Examining the pathogenesis of COPD is extremely important for COPD prevention and treatment. To date, however, there is no medication for chronic obstructive pulmonary disease that can delay the lung function decline over time. According to studies, vitamin D offers new hope for the treatment of COPD. A deficiency in vitamin D can exacerbate the progression of COPD, whereas adequate vitamin D has a therapeutic effect on COPD. This paper summarizes the relevant domestic and international research, discusses the possible mechanism of vitamin D’s effect on COPD, and investigates the role of vitamin D, particularly in COPD patients.

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IL-17 Cytokines and Chronic Lung Diseases

Cited by 50 publications

References 149 publications

RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

Diagnosis values of Dectin-1 and IL-17 levels in plasma for invasive pulmonary aspergillosis in bronchiectasis

Vitamin D and Chronic Obstructive Pulmonary Disease

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