IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression

Obeed, Omar A Al; Vaali-Mohammed, Mansoor-Ali; Al‐Khayal, Khayal; Traiki, Thamer A. Bin; Zubaidi, Ahmad; Arafah, Maha; Harris, Robert A.; Khan, Zahid; Abdulla, Maha-Hamadien

doi:10.2147/cmar.s161248

Cited by 22 publications

(21 citation statements)

References 46 publications

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“…Thus, the overall effect of IL17 is apparently linked to the localization of IL17-producing cells. A further complication in the definition of the pro-tumor properties of IL17 comes from the IL17A polymorphism rs2275913 (G197A), with the AG and AA genotypes strongly associated to an increased CRC incidence (187–191).…”

Section: Nk Cells In Colorectal Cancer (Crc)mentioning

confidence: 99%

Human Gut-Associated Natural Killer Cells in Health and Disease

et al. 2019

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It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals and virus infections. The functions of NK cells in the gut are much more complex. Gut NK cells are not precisely organized in lymphoid aggregates but rather scattered in the epithelium or in the stroma, where they come in contact with a multitude of antigens derived from commensal or pathogenic microorganisms in addition to components of microbiota. Furthermore, NK cells in the bowel interact with several cell types, including epithelial cells, fibroblasts, macrophages, dendritic cells, and T lymphocytes, and contribute to the maintenance of immune homeostasis and development of efficient immune responses. NK cells have a key role in the response to intestinal bacterial infections, primarily through production of IFNγ, which can stimulate recruitment of additional NK cells from peripheral blood leading to amplification of the anti-bacterial immune response. Additionally, NK cells can have a role in the pathogenesis of gut autoimmune inflammatory bowel diseases (IBDs), such as Crohn's Disease and Ulcerative Colitis. These diseases are considered relevant to the generation of gastrointestinal malignancies. Indeed, the role of gut-associated NK cells in the immune response to bowel cancers is known. Thus, in the gut immune system, NK cells play a dual role, participating in both physiological and pathogenic processes. In this review, we will analyze the known functions of NK cells in the gut mucosa both in health and disease, focusing on the cross-talk among bowel microenvironment, epithelial barrier integrity, microbiota, and NK cells.

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Section: Nk Cells In Colorectal Cancer (Crc)mentioning

confidence: 99%

Human Gut-Associated Natural Killer Cells in Health and Disease

et al. 2019

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“…Recently, several studies investigated the association between IL-17A rs2275913 polymorphism and risk of CRC [9,11,13–15]. Omrane et al firstly conducted a population-based study to explore the association of rs2275913 polymorphism with CRC risk in a Tunisian population involving 102 CRC patients and 139 controls [11].…”

Section: Discussionmentioning

confidence: 99%

“…However, no significant association with CRC risk was observed for rs2275913 polymorphism in another Tunisian study conducted by Bedoui et al [15]. Additionally, two Caucasian studies also investigated the effect of this SNP on the risk of CRC [9,13]. Nemati et al revealed that AG genotype showed a significantly elevated risk for CRC compared to GG genotype in the Iranian population [13].…”

Section: Discussionmentioning

confidence: 99%

“…Th17-type cytokines (IL-17A, IL-17F, IL-21, IL-22), IL-6 and tumor necrosis factor-α synergistically activate STAT3 and NF-κB to promote CRC growth [8]. Single-nucleotide polymorphism (SNP) in IL-17 gene may influence genomic stability and increase the production of IL-17, thereby conferring susceptibility to CRC [9].…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have investigated the association between IL-17 gene polymorphisms and risk of CRC [9–15], mainly focusing on two polymorphisms (rs2275913, IL-17A ; rs763780, IL-17F ). However, their findings were conflicting.…”

Section: Introductionmentioning

confidence: 99%

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The association between IL-17 gene variants and risk of colorectal cancer in a Chinese population: A case–control study

Feng

Ying²,

Chai

et al. 2019

Bioscience Reports

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Interleukin (IL)-17 have been reported to be associated with the pathogenesis of colorectal cancer (CRC). Few studies investigated the association between IL-17 gene polymorphisms and risk of CRC with inconsistent findings. Thus, we recruited 352 CRC cases and 433 controls in a Chinese population and their genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method. Our data showed that IL-17A rs2275913 polymorphism was associated with the increased risk of CRC, while no association was observed for IL-17F rs763780 polymorphism. Stratified analyses revealed that the significant association was also obtained in the females, smokers, drinkers and age ≥ 60 years groups for rs2275913 polymorphism. Moreover, the CC and/or GC genotype of rs2275913 polymorphism were correlated with TNM stage and lymph node metastasis. No association was shown between IL-17F rs763780 polymorphism and clinical characteristics of CRC. In conclusion, our data indicate that IL-17A rs2275913 polymorphism but not IL-17F rs763780 polymorphism contributes to increased risk for CRC patients in this Chinese population.

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