IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation

Smith, Siobhan; Wu, Pei; Seo, Jane J.; Fernando, Thilini R.; Jin, Mengyao; Contreras, Jorge E.; Montano, Erica N.; Gabhann, Joan Ní; Cunningham, Kyle; Widaa, Amro; McCarthy, Eoghan; Molloy, Eamonn; Kearns, Grainne; Murphy, Conor C; Kong, Wan Yee; Björkbacka, Harry; Kornfeld, Hardy; Forbess, Lindsy; Venuturupalli, Swamy; Ishimori, Mariko; Wallace, Daniel J.; Weisman, Michael H.; Jefferies, Caroline A.

doi:10.1172/jci.insight.120798

Cited by 35 publications

(39 citation statements)

References 67 publications

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“…And its role in pathogenesis of lung diseases is shown by its correlation with facilitated disease progression in NSCLC . In addition, miR‐125a low expression is previously reported to induce neutrophil recruitment and regulate lung inflammation in SLE . Known that miR‐125a is a target of lncRNA ANRIL, and both lncRNA ANRIL and miR‐125a regulate inflammatory responses including lung inflammation, we hypothesized that lncRNA ANRIL might interact with miR‐125a, and lncRNA ANRIL/miR‐125a axis might play critical roles in bronchial asthma as well.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the previous evidence, lncRNA ANRIL and miR‐125a are both associated with inflammatory cytokine levels in inflammatory diseases. In addition, downregulated miR‐125a is previously shown to induce alveolar damage and hemorrhage in the lung in SLE patients . However, whether lncRNA ANRIL/miR‐125a axis affects inflammatory cytokine in inflammatory lung diseases, especially bronchial asthma, is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Although there are existing inflammatory cytokines for asthma monitoring, the inflammatory cytokine level change is a result from inflammatory response, and their expression could be altered in various inflammatory diseases or affected by other pathological conditions other than asthma, which might lack specificity in asthma. However, ANRIL/miR‐125a axis is shown to regulate inflammatory response in genetic level and involves in pathogenesis of asthma in other ways such as damage to bronchial and alveolar cells . Therefore, ANRIL/miR‐125a axis would be more beneficial to diagnose asthma exacerbation or to monitor the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, lncRNA ANRIL also facilitates the pathological progression in pulmonary diseases, and for instance, lncRNA ANRIL promotes cells proliferation and metastasis in non–small‐cell lung cancer (NSCLC) . MicroRNA‐125a (miR‐125a), as one of the target genes of lncRNA ANRIL, is downregulated in several inflammatory diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and Crohn's disease . In addition, decreased level of miR‐125a is associated with lung inflammation and acute alveolar hemorrhage in SLE patients by recruiting of neutrophils .…”

Section: Introductionmentioning

confidence: 99%

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LncRNA ANRIL/miR‐125a axis exhibits potential as a biomarker for disease exacerbation, severity, and inflammation in bronchial asthma

Zhu

Feng

2019

Clinical Laboratory Analysis

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Background This study aimed to explore the correlation of lncRNA ANRIL/miR‐125a axis with disease risk, severity, and inflammatory cytokines of bronchial asthma. Methods Plasma samples from 90 patients with bronchial asthma at exacerbation (BA‐E), 90 with bronchial asthma at remission (BA‐R), and 90 controls (healthy subjects) were collected. The qPCR was used for lncRNA ANRIL and miR‐125a detection, and ELISA was adopted for pro‐inflammatory cytokines detection. Participants’ characteristics, laboratory tests, and the pulmonary ventilation function examinations were recorded. Results LncRNA ANRIL was negatively correlated with miR‐125a in BA‐E patients, BA‐R patients, and controls. LncRNA ANRIL/miR‐125a axis was upregulated in BA‐E patients compared with BA‐R patients and controls. ROC curve analyses illuminated that lncRNA ANRIL/miR‐125a axis was of good value in distinguishing BA‐E patients from BA‐R patients and controls. As to pulmonary ventilation functions, lncRNA ANRIL/miR‐125a axis was negatively associated with FEV1/FVC and FEV1%predicted in bronchial asthma patients, especially in BA‐E patients. Regarding inflammation, lncRNA ANRIL/miR‐125a axis was positively correlated with pro‐inflammatory cytokines in bronchial asthma patients, especially in BA‐E patients. In addition, lncRNA ANRIL/miR‐125a axis was positively correlated with exacerbation severity in BA‐E patients. Conclusion LncRNA ANRIL/miR‐125a is potentially indicative of disease exacerbation, exacerbation severity, and inflammation for bronchial asthma, while these findings are preliminary and need further confirmation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LncRNA ANRIL/miR‐125a axis exhibits potential as a biomarker for disease exacerbation, severity, and inflammation in bronchial asthma

Zhu

Feng

2019

Clinical Laboratory Analysis

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“…miR‐125a, a highly reserved miRNA locating on chromosome 19, 11, and 21, is also closely related to inflammation and immunity, and this miRNA has been reported to have the potential in regulating sepsis pathogenesis . Moreover, it is a direct target of lnc‐ANRIL, and the lnc‐ANRIL/miR‐125a axis has been indicated in many diseases . However, the role of lnc‐ANRIL/miR‐125a axis in sepsis remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Elevated circulating lnc‐ANRIL/miR‐125a axis level predicts higher risk, more severe disease condition, and worse prognosis of sepsis

Gui

Peng

Liu

2019

Clinical Laboratory Analysis

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Aim This study aimed to investigate the correlation of lnc‐ANRIL/miR‐125a axis with risk, severity, inflammation, and prognosis of sepsis. Methods A hundred and twenty‐six sepsis patients and 125 healthy controls were recruited, and then, blood samples were collected, and plasma was separated for lnc‐ANRIL, miR‐125a, lnc‐ANRIL/miR‐125a axis, and inflammatory cytokine level detections. In addition, basic characteristics, 28‐day mortality, and accumulating survival of sepsis patients were recorded. Results Plasma lnc‐ANRIL expression was increased, miR‐125a expression was decreased, and lnc‐ANRIL/miR‐125a axis level was elevated in sepsis patients compared with healthy controls, and all of them had good value for predicting sepsis risk with AUCs of 0.800, 0.817, and 0.843, respectively. Lnc‐ANRIL and lnc‐ANRIL/miR‐125a axis were positively correlated with biochemical index levels including CRP and PCT levels, disease severity scale scores, and pro‐inflammatory cytokine levels in sepsis patients, while miR‐125a displayed the opposite trend. Lnc‐ANRIL and lnc‐ANRIL/miR‐125a axis expressions were elevated, while miR‐125a expression was declined in deaths compared with survivors, and all of them predicted 28‐day mortality in sepsis patients with AUCs of 0.765, 0.745, and 0.785, respectively. Subsequently, the Kaplan‐Meier analysis revealed that patients with high lnc‐ANRIL, low miR‐125a, and high lnc‐ANRIL/miR‐125a axis levels presented with worse accumulating survival. In addition, multivariate regression model analyses revealed that high plasma lnc‐ANRIL/miR‐125a axis was an independent predictive factor for both increased 28‐day mortality and worse accumulating survival. Conclusion Circulating lnc‐ANRIL/miR‐125a axis was upregulated and could serve as a biomarker for severity, inflammation, and prognosis in sepsis patients.

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MicroRNA as a potential biomarker for systemic lupus erythematosus: pathogenesis and targeted therapy

Naithani,

Jain,

Sachan

et al. 2023

Clin Exp Med

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IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation

Cited by 35 publications

References 67 publications

LncRNA ANRIL/miR‐125a axis exhibits potential as a biomarker for disease exacerbation, severity, and inflammation in bronchial asthma

LncRNA ANRIL/miR‐125a axis exhibits potential as a biomarker for disease exacerbation, severity, and inflammation in bronchial asthma

Elevated circulating lnc‐ANRIL/miR‐125a axis level predicts higher risk, more severe disease condition, and worse prognosis of sepsis

MicroRNA as a potential biomarker for systemic lupus erythematosus: pathogenesis and targeted therapy

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