IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor

Jackson, Nicole; Wang, Hong Wei; Tedla, Nicodemus; McNeil, H. Patrick; Geczy, Carolyn L.; Collins, Andrew M.; Grimm, Michael; Hampartzoumian, Taline; Hunt, John

doi:10.1002/eji.200526154

Cited by 21 publications

(13 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has not yet been reported whether hCBMC express the same receptors. However, IL-15 induced migration of both mBMMC and hCBMC in a dose-responsive and biphasic manner, supports the possibility that this effect is mediated by two distinct IL-15R with different affinities to IL-15 (Jackson et al, 2005). Interestingly, in stimulated dendritic cells (DC), IL-15, and IL-15Rα are preassembled in complexes within the endoplasmic reticulum/Golgi before being released from the cells.…”

Section: Interleukin Receptors and Tslprsupporting

confidence: 54%

Novel Identified Receptors on Mast Cells

Migalovich-Sheikhet¹,

Friedman²,

Mankuta³

et al. 2012

Front. Immun.

View full text Add to dashboard Cite

Mast cells (MC) are major participants in the allergic reaction. In addition they possess immunomodulatory roles in the innate and adaptive immune reactions. Their functions are modulated through a number of activating and inhibitory receptors expressed on their surface. This review deals with some of the most recently described receptors, their expression patterns, ligand(s), signal transduction mechanisms, possible cross-talk with other receptors and, last but not least, regulatory functions that the MC can perform based on their receptor expression in health or in disease. Where the receptor role on MC is still not clear, evidences from other hematopoietic cells expressing them is provided as a possible insight for their function on MC. Suggested strategies to modulate these receptors’ activity for the purpose of therapeutic intervention are also discussed.

show abstract

Section: Interleukin Receptors and Tslprsupporting

confidence: 54%

Novel Identified Receptors on Mast Cells

Migalovich-Sheikhet¹,

Friedman²,

Mankuta³

et al. 2012

Front. Immun.

View full text Add to dashboard Cite

show abstract

“…Moreover, IL-15 was found to prevent mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression providing a mechanism for its anti-apoptotic effects [51]. IL-15 was also able to induce the migration of mouse and human mast cells with a potency of response that was similar to those induced by other well-established mast cell chemoattractants [52]. In addition, the IL-15-induced migration of both mouse and human mast cells was dependent on the expression of a pertussis toxin-sensitive receptor, activated in response to IL-15 [52].…”

Section: Role Of Il-15 On Innate Immune Cellsmentioning

confidence: 99%

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

Perera

Lichy

Waldmann

et al. 2012

Microbes and Infection

166

108

View full text Add to dashboard Cite

Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. This review provides an overview of the mechanisms by which IL-15 modulates the host response to infectious agents and its utility as a cytokine adjuvant in vaccines against infectious pathogens.

show abstract

“…Their localized accumulation may be due to redistribution of neighboring MC in response to factors such as stem cell factor, transforming growth factor-␤, C5a, CXC chemokines (30), and interleukin-15 (31). Our recent studies showed S100A12 to be a potent activator of MC, and its expression in macrophages in the vicinity of tryptase-positive MC, in eosinophils infiltrating the airways of patients with asthma, and elevated levels in the sputum of patients with eosinophilic asthma implicate it in pathogenesis (4).…”

Section: Discussionmentioning

confidence: 99%

Mast Cell and Monocyte Recruitment by S100A12 and Its Hinge Domain

Yan

Armishaw

Goyette

et al. 2008

Journal of Biological Chemistry

View full text Add to dashboard Cite

S100A12 is expressed at sites of acute, chronic, and allergic inflammation. S100 proteins have regions of high sequence homology, but the "hinge" region between the conserved calcium binding domains is structurally and functionally divergent. Because the murine S100A8 hinge domain (mS100A8 [42][43][44][45][46][47][48][49][50][51][52][53][54][55] ) is a monocyte chemoattractant whereas the human sequence (hS100A8 [43][44][45][46][47][48][49][50][51][52][53][54][55][56] ) is inactive, we postulated that common hydrophobic amino acids within the S100A12 hinge sequence may be functional. The hinge domain, S100A12 38 -53 , was chemotactic for human monocytes and murine mast cells in vitro. S100A12 38 -53 provoked an acute inflammatory response similar to that elicited by S100A12 in vivo and caused edema and leukocyte and mast cell recruitment. Circular dichroism studies showed that S100A12 38 -53 had increased helical structure in hydrophobic environments. Mutations in S100A12 38 -53 produced using an alanine scan confirmed that specific hydrophobic residues (I44A, I47A, and I53A) on the same face of the helix were critical for monocyte chemotaxis in vitro and generation of edema in vivo. In a hydrophobic environment such as the cell membrane, these critical residues would likely align on one face of an ␣-helix to facilitate receptor interaction. Interaction is unlikely to occur via the receptor for advanced glycation end products but, rather, via a G-protein-coupled mechanism.

show abstract

IL-15 induces mast cell migration via a pertussis toxin-sensitive receptor

Cited by 21 publications

References 56 publications

Novel Identified Receptors on Mast Cells

Novel Identified Receptors on Mast Cells

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

Mast Cell and Monocyte Recruitment by S100A12 and Its Hinge Domain

Contact Info

Product

Resources

About