IL-13 polymorphisms contribute to the risk of asthma: A meta-analysis

Cui, Lin; Jia, Jun; Ma, Chao; Li, Suyun; Wang, Youping; Guo, Xiaomin; Li, Qiang; Yu, Haibin; Liu, Weihong; Gao, Linbo

doi:10.1016/j.clinbiochem.2011.12.012

Cited by 39 publications

(38 citation statements)

References 35 publications

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“…These potential confounding factors may interact with TLR polymorphisms to moderate asthma susceptibility. Genetic associations were shown to be significantly influenced by age75,76,77,78 likely because some genes are expressed in adults and not expressed in children and vice versa . Observational studies showed that the prevalence of asthma has increased during the last decade due to environmental factors 3.…”

Section: Discussionmentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Tizaoui

Kaabachi

Hamzaoui

et al. 2015

Allergy Asthma Immunol Res

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PurposeAsthma is a complex disease, with contributions from multiple genes, various genetic backgrounds, and environmental factors. Many human epidemiological studies have demonstrated that single nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes are inconsistently associated with asthma risk. Some have demonstrated differences concerning the study design and effect size, and conflicting results have been reported. A meta-analysis is necessary to determine the magnitude of this association.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, a systematic search and meta-analysis of the literature was conducted to estimate the association of SNPs in TLR genes with asthma risk. We screened the medical literature based on the following keyword searches in MEDLINE and EMBASE databases: 'TLR', 'polymorphism', 'asthma', and their combinations.ResultsMeta-analysis of eight studies on TLR4 Asp299Gly showed a marginal association of TLR4 with asthma risk (odds ratio [OR]=0.814 [95% confidence interval [CI], 0.652-1.016; P=0.069]) in the recessive model. TLR4 Thr399Ile was not associated with asthma risk under any genetic model. Meta-analysis of four studies on TLR2 Arg753Gln indicated that TLR2 might be significantly associated with asthma in the dominant and codominant models (P=0.029, P=0.030, and P=0.009, respectively). TLR9 -1237 was marginally associated with asthma risk (OR=0.408 [95% CI, 0.163-1.021; P=0.065]) in the codominant model. Analysis using the allele contrast model showed that the major TLR9 -1237 T allele tended to be a significant protective factor with OR=0.689 (95% CI, 0.471-1.007; P=0.055).ConclusionsThe results showed that TLR4 Asp299Gly, TLR2 Arg753Gln, and TLR9-1237 might contribute significantly to asthma susceptibility. Future genetic association studies would consolidate these findings.

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Section: Discussionmentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Tizaoui

Kaabachi

Hamzaoui

et al. 2015

Allergy Asthma Immunol Res

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“…This polymorphism was associated with asthma and atopic dermatitis in GWAS studies [30,31]. Meta-analysis done by Cui et al [1] also reported an association between this polymorphism and asthma, which was confirmed in cohort studies by Black et al [32], followed by an association with allergy and allergic rhinitis. DeMeo et al [21] reported no association between rs20541 and asthma, but confirmed its influence on eosinophilia, positive skin prick test results and higher IgE serum levels.…”

Section: Discussionmentioning

confidence: 81%

“…In interleukin 13 gene, a functional SNP contributing to aminoacid substitution R110Q (rs20541) was described to change the binding strength of IL13 to its receptor, causing higher activity of Gln110 variant [20]. Numerous studies showed that this polymorphism correlated significantly with higher total IgE levels, atopic dermatitis and asthma [1,21,22].…”

Section: Introductionmentioning

confidence: 98%

“…Both interleukin 4 (IL4) and interleukin 13 (IL13) are cytokines produced mainly by T-helper 2 (Th2) cells and they play a crucial role in the pathogenesis of allergic inflammation including allergic asthma [1,2]. Interleukin 4 and interleukin 13 recruit mast cells and eosinophils, induce isotype class-switching of B-cells for IgE synthesis and regulate expression of MHC II, CD23 and VCAM-1 [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: A case control study

Narożna

Hoffmann

Sobkowiak

et al. 2016

Advances in Medical Sciences

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“…Previous studies have also shown that they have strong antitumor activity in mice and inhibit proliferation of astrocytoma and low-grade glioma in human cell lines [11,12]. Furthermore, polymorphisms of IL-4R and IL-13 have been reported to be associated with asthma risk [13,14]. Considering the strong biological rational, several epidemiological studies have investigated the associations between IL-4/IL-13 pathway genetic polymorphisms and risk of glioma but have yielded contradictory results [15][16][17].…”

Section: Introductionmentioning

confidence: 93%

Polymorphisms in IL-4/IL-13 pathway genes and glioma risk: an updated meta-analysis

Chen

et al. 2014

Tumor Biol.

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Polymorphisms in interleukin (IL)-4/IL-13 pathway genes have previously been reported to be associated with glioma susceptibility, although results are inconsistent. We therefore performed an updated meta-analysis to determine a more precise estimation of this relationship. Twelve eligible studies were identified by searching PubMed, EMBASE, Web of Science, and the Cochrane Library electronic databases. Nine polymorphisms in genes within the IL-4/IL-13 pathway (IL-4 rs2243250, rs2070874, rs2243248, IL-4R rs1805011, rs1805012, rs1805015, rs1801275, and IL-13 rs20541 and rs1800925) were assessed for their relationship with glioma risk by computing odds ratios (ORs) and corresponding 95 % confidence intervals (CIs). Akaike's information criterion (AIC) was used to identify the best genetic model for each polymorphism. No association between IL-4/IL-13 pathway genetic polymorphisms and glioma risk was observed in the overall population, although a significant association was found between rs2234248 and glioblastoma when stratified by histological subtype (log-additive model, OR 1.57, 95 % CI 1.11-2.24). This meta-analysis therefore suggested that IL-4/IL-13 pathway genetic polymorphisms are not associated with glioma risk.

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IL-13 polymorphisms contribute to the risk of asthma: A meta-analysis

Cited by 39 publications

References 35 publications

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis

Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: A case control study

Polymorphisms in IL-4/IL-13 pathway genes and glioma risk: an updated meta-analysis

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