IL-13 induces CD34+ cells isolated from G-CSF mobilized blood to differentiate in vitro into potent antigen presenting cells

Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice

“…MoDCs were generated in vitro from human peripheral blood CD14 ϩ cells by using 3 different procedures that yielded DCs functionally similar in their ability to prime T cells: [10][11][12] in the presence of GM-CSF and IL-4 10 ; in the presence of GM-CSF and IL-13 11 ; or in the presence of GM-CSF and IL-15. 12 These MoDCs were equally able to undergo maturation after interaction with LPS and CD40L, as assessed by the up-regulation of activation markers, such as CD80, CD86, and CD83 ( Figure 1A).…”

Immunologic Profiles of Effector Cells and Peripheral Blood Stem Cells Mobilized with Different Hematopoietic Growth Factors

“…Dendritic cells constitute the most effective antigen presenting cells and therefore are the most important regulatory element of the cellular immune response [39]. Differentiation to dendritic cells can be induced from CD14 + monocytes using IL‐4 and GM‐CSF [40], or from CD34 + cells by a great variety of growth factors such as GM‐CSF plus tumor necrosis factor‐α (TNF‐α) [41, 42], SCF plus GM‐CSF and IL‐4 or TNF‐α [43‐45], IL‐13 [46], IL‐15 [47], and flt3 ligand with TGF‐β [48, 49].…”

Modulation of Cytokines Production by Indomethacin Acute Dose during the Evolution of Ehrlich Ascites Tumor in Mice

“…Reports in the literature associated IL-13 with inhibition of tumor proliferation [ 41 ], by increasing antigen presentation to T cells [ 42 ]. In addition, IL-13, among other functions, stimulates proliferation of B cells and cytotoxic T cells.…”