IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo
Shreya Ghimire,
Biyun Xue,
Kun Li
et al.
Abstract:Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved and emerging cytokine signaling-modulating antibodies is variable and is affected by disease course and patient-specific inflammation patterns. Therefore, understanding the role of inflammation on the viral infectious cycle is critical for effective use of cytokine-modulating agents. We investigated the role of… Show more
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