IL-13 and the hydroperoxy fatty acid 13(S)HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis

Biswas, Pritam; Swaroop, Surbhi; Dutta, Naibedya; Arya, Aditi; Ghosh, Suvranil; Dhabal, Sukhamoy; Das, Payel; Majumder, Chirantan; Pal, Mahadeb; Bhattacharjee, A.

doi:10.1016/j.freeradbiomed.2022.12.103

Cited by 8 publications

(3 citation statements)

References 44 publications

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“…Baldi et al showed that the ferroptosis-related gene-activated TGFB pathway could stimulate ROS generation to promote tumor invasion and progression [ 58 ]. In addition, Biswas et al found that MAO-A-mediated ROS accumulation is a key factor in cancer apoptosis [ 59 ]. All these facts suggest that the abnormal accumulation of ROS in cancer cells is mediated by multiple mechanisms for tumor response.…”

Section: Ros Levels In Cancer Cells and Cancer Developmentmentioning

confidence: 99%

Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Zhao

Xiong

et al. 2023

Metabolites

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Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of cancer treatment research. Abnormally elevated ROS levels are often attributable to alterations in cellular metabolic activities and increased oxidative stress, which affects both the development and maintenance of cancer. Moderately high levels of ROS are beneficial to maintain tumor cell genesis and development, while toxic levels of ROS have been shown to be an important force in destroying cancer cells. ROS has become an important anticancer target based on the proapoptotic effect of toxic levels of ROS. Therefore, this review summarizes the role of increased ROS in DNA damage and the apoptosis of cancer cells caused by changes in cancer cell metabolism, as well as various anticancer therapies targeting ROS generation, in order to provide references for cancer therapies based on ROS generation.

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Section: Ros Levels In Cancer Cells and Cancer Developmentmentioning

confidence: 99%

Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Zhao

Xiong

et al. 2023

Metabolites

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“…13(S)-HPODE is involved in linoleic acid metabolism and leads to a reduction in intestinal inflammation and changes in the body weight of mice ( Zhang, et al, 2024 ). Moreover, 13(S)-HPODE is a natural activator of the cancer therapeutic target PPARγ, which can effectively promote apoptosis of cancer cells in the body ( Biswas, et al, 2023 ). Arachidonic acid is a polyunsaturated fatty acid found primarily in cell membranes as a phospholipid.…”

Section: Discussionmentioning

confidence: 99%

Dietary succinate reduces fat deposition through gut microbiota and lipid metabolism in broilers

Wang,

Feng,

Yao

et al. 2024

Poultry Science

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“…In addition, our study showed that 13-(S)-HODPE, PC and PE were key metabolites in lipid metabolism. It is reported that 13-(S)-HODPE can increase the production of ROS and promote the expression of apoptotic genes such as caspase-3 and p21, thus promoting cell apoptosis ( 71 ). The present study showed that MCE decreased the level of 13-(S)-HODPE, suggesting that MCE may inhibit oxidant stress by reducing the 13-(S)-HODPE level.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites

Wang,

Zhang,

et al. 2024

Front. Immunol.

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IntroductionThe prevention and mitigation of intestinal immune challenge is crucial for poultry production. This study investigated the effects of dietary Macleaya cordata extract (MCE) supplementation on the prevention of intestinal injury in broiler chickens challenged with lipopolysaccharide (LPS).MethodsA total of 256 one-day-old male Arbor Acres broilers were randomly divided into 4 treatment groups using a 2×2 factorial design with 2 MCE supplemental levels (0 and 400 mg/kg) and 2 LPS challenge levels (0 and 1 mg/kg body weight). The experiment lasted for 21 d.Results and discussionThe results showed that MCE supplementation increased the average daily feed intake during days 0-14. MCE supplementation and LPS challenge have an interaction on the average daily gain during days 15-21. MCE supplementation significantly alleviated the decreased average daily gain of broiler chickens induced by LPS. MCE supplementation increased the total antioxidant capacity and the activity of catalase and reduced the level of malondialdehyde in jejunal mucosa. MCE addition elevated the villus height and the ratio of villus height to crypt depth of the ileum. MCE supplementation decreased the mRNA expression of pro-inflammatory cytokines interleukin (IL)-6 and IL-8 in the jejunum. MCE addition mitigated LPS-induced mRNA up-expression of pro-inflammatory factors IL-1β and IL-17 in the jejunum. MCE supplementation increased the abundance of probiotic bacteria (such as Lactobacillus and Blautia) and reduced the abundance of pathogenic bacteria (such as Actinobacteriota, Peptostretococcaceae, and Rhodococcus), leading to alterations in gut microbiota composition. MCE addition altered several metabolic pathways such as Amino acid metabolism, Nucleotide metabolism, Energy metabolism, Carbohydrate metabolism, and Lipid metabolism in broilers. In these pathways, MCE supplementation increased the levels of L-aspartic acid, L-Glutamate, L-serine, etc., and reduced the levels of phosphatidylcholine, phosphatidylethanolamine, thromboxane B2, 13-(S)-HODPE, etc. In conclusion, dietary supplementation of 400 mg/kg MCE effectively improved the growth performance and intestinal function in LPS-challenged broiler chickens, probably due to the modulation of gut microbiota and plasma metabolites.

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IL-13 and the hydroperoxy fatty acid 13(S)HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis

Cited by 8 publications

References 44 publications

Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Dietary succinate reduces fat deposition through gut microbiota and lipid metabolism in broilers

Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites

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