IL-12 producing monocytes and IFN-γ and TNF-α producing T-lymphocytes are increased in placentas infected by Plasmodium falciparum

Diouf, Ibrahima; Fiévet, Nadine; Doucouré, Souleymane; Ngom, Mamadou I.; Andrieu, Muriel; Mathieu, Jean-François; Gaye, Alioune; Thiaw, Omar Thiom; Deloron, Philippe

doi:10.1016/j.jri.2006.10.001

Cited by 45 publications

(35 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Remarkably, P. falciparum infection differentially modulates the cytokine production of in vitro-stimulated mononuclear cells isolated from the intervillous space of women at delivery. The proportion of IFN-␥-producing NK cells appears to be decreased in parasite-infected women compared to uninfected ones (15), whereas the frequency of IFN-␥-and TNF-␣-producing T lymphocytes has been reported to be increased during infection, suggesting an important role of T cell activity in protection (16). Furthermore, P. falcipa-rum infection seems to favor IL-12 production rather than TNF-␣ production by placental monocytes/macrophages (16).…”

mentioning

confidence: 95%

Placental Cytokine and Chemokine Profiles Reflect Pregnancy Outcomes in Women Exposed to Plasmodium falciparum Infection

et al. 2014

Self Cite

View full text Add to dashboard Cite

g Pregnancy-associated malaria (PAM) can lead to severe complications for both mother and baby. Certain placental cytokine/ chemokine profiles have been shown to reflect poor pregnancy outcomes, including maternal anemia and low birth weight. In intervillous plasma samples from 400 Beninese women living in an area where Plasmodium falciparum is endemic, we quantified 16 cytokines/chemokines. We assessed their profiles in groups with PAM, with maternal anemia, with preterm births, or with a low birth weight for gestational age. Repeated ultrasound measurements ensured that prematurity and low birth weight were highly accurate. Preliminary analyses revealed trends for lower cytokine/chemokine concentrations in placental plasma associated both with babies with low birth weight for gestational age and with P. falciparum infection during pregnancy, while, as a function of the latter, the concentration of gamma interferon (IFN-␥)-inducible protein 10 (IP-10) was higher. Multivariate analyses showed that (i) higher placental plasma interleukin-10 (IL-10) levels were associated with P. falciparum infections and (ii) independently of P. falciparum infections, lower concentrations of both IFN-␥ and IL-5 were associated with low birth weight for gestational age. Our data further strengthen the idea that IL-10 and IP-10 could be useful diagnostic markers of P. falciparum infection during pregnancy. The concentrations of cytokines/chemokines in placental plasma may represent previously unrecognized markers of poor fetal growth.

show abstract

mentioning

confidence: 95%

Placental Cytokine and Chemokine Profiles Reflect Pregnancy Outcomes in Women Exposed to Plasmodium falciparum Infection

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…One of the key pathogenic mechanisms in the virulence of P. falciparum is the phenomenon of cytoadherence, attributed to increased adhesion of infected erythrocytes to blood capillaries [34][35][36][37][38][39][40][41][42] .…”

Section: Discussionmentioning

confidence: 99%

“…In particular, cerebral and placental malaria seem to be dependent on crucial protein-protein interactions that occur between a parasite virulence factors and the endothelial/placental receptors [34][35][36][37][38][39][40][41][42] . The host immune system is hijacked by parasite-derived factors to assist in cytoadherence, for example, by cytokine-induced increased expression of a range of adhesion molecules 16,[18][19][20][21][22][23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

“…Elevated cytokine levels have a variety of physiological effects, generally to the detriment of the hosts 16,[34][35][36][37][38][39][40][41][42] . In fact, malaria as a disease has been looked up on as a manifestation of enhanced pro-inflammatory cytokine production in host 16,[34][35][36][37][38][39][40][41][42] . For example, the clinical manifestations of severe malaria can be correlated with induction of strong pro-inflammatory responses in which plasma levels of circulating TNF-α, IFN-γ and IL-6 increase significantly [19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

“…Increased circulating TNF-α inhibits erythroblast differentiation and dampens erythropoiesis resulting in worsening SMA symptoms [16][17][18][19][20][21]45 . Another outcome of higher levels of circulating TNF-α in infected malaria patients is the increase in expression levels of certain endothelial receptors like ICAM-1, VCAM-1 and E-selectin that contribute to cytoadherence in severe malaria [39][40][41][42] . Our data based on co-incubation of three components-purified PfTyrRS macrophages and endothelial cells, now provides a system that can be further dissected to investigate molecular and cellular interactions that occur during SMA and cytoadherence.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses

et al. 2011

View full text Add to dashboard Cite

malaria infection triggers pro-inflammatory responses in humans that are detrimental to host health. Parasite-induced enhancement in cytokine levels correlate with malariaassociated pathologies. Here we show that parasite tyrosyl-tRnA synthetase (PfTyrRs), a housekeeping protein translation enzyme, induces pro-inflammatory responses from host immune cells. PfTyrRs exits from the parasite cytoplasm into the infected red blood cell (iRBC) cytoplasm, from where it is released into the extracellular medium on iRBC lysis. using its ELR peptide motif, PfTyrRs specifically binds to and internalizes into host macrophages, leading to enhanced secretion of the pro-inflammatory cytokines TnF-α and IL-6. PfTyrRs-macrophage interaction also augments expression of adherence-linked host endothelial receptors ICAm-1 and VCAm-1. our description of PfTyrRs as a parasite-secreted protein that triggers proinflammatory host responses, along with its atomic resolution crystal structure in complex with tyrosyl-adenylate, provides a novel platform for targeting PfTyrRs in anti-parasitic strategies.

show abstract

Physiopathology of Malaria During Pregnancy: Pregnancy-Specific Malaria Immune Responses

Mayor¹,

Ibitokou²,

Deloron³

2015

Encyclopedia of Malaria

View full text Add to dashboard Cite

IL-12 producing monocytes and IFN-γ and TNF-α producing T-lymphocytes are increased in placentas infected by Plasmodium falciparum

Cited by 45 publications

References 42 publications

Placental Cytokine and Chemokine Profiles Reflect Pregnancy Outcomes in Women Exposed to Plasmodium falciparum Infection

Placental Cytokine and Chemokine Profiles Reflect Pregnancy Outcomes in Women Exposed to Plasmodium falciparum Infection

Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses

Physiopathology of Malaria During Pregnancy: Pregnancy-Specific Malaria Immune Responses

Contact Info

Product

Resources

About