IL-11 activated by lnc-ATB promotes cell proliferation and invasion in esophageal squamous cell cancer

Yang, Shengyuan; Li, Suyi; Yu, Hongbo; Lin-yan, Xu; Xiang, Song

doi:10.1016/j.biopha.2019.108835

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…Among the interleukin family, secretion of IL-33 in esophageal epithelial cells has been reported to prompt the occurrence of gastroesophageal reflux diseases and lead to Barrett esophagus; 31 IL-4, IL-13, 32 IL-1β 33 and IL-6 34 contributed to increased secretion of esophageal mucosa in patients with Barrett's esophagus, and IL-11 contributed to esophageal squamous cell carcinoma progression and its aggressiveness. 35 Nonetheless, to date, no study has reported the role of IL-11 in EAC, and our study fills this gap and confirms the potentially important role of it in EAC prognosis. IL-11 is a member of the IL-6 family of cytokines, 36 and has been recognized for its role in the disease pathogenesis of mucosal homeostasis including gastrointestinal cancers.…”

Section: Discussionsupporting

confidence: 76%

“…Our results showed that IL‐11 could potentially be used as an independent prognostic factor for EAC. Among the interleukin family, secretion of IL‐33 in esophageal epithelial cells has been reported to prompt the occurrence of gastroesophageal reflux diseases and lead to Barrett esophagus; 31 IL‐4, IL‐13, 32 IL‐1β 33 and IL‐6 34 contributed to increased secretion of esophageal mucosa in patients with Barrett's esophagus, and IL‐11 contributed to esophageal squamous cell carcinoma progression and its aggressiveness 35 . Nonetheless, to date, no study has reported the role of IL‐11 in EAC, and our study fills this gap and confirms the potentially important role of it in EAC prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Multivariate gene expression‐based survival predictor model in esophageal adenocarcinoma

et al. 2020

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Background: Despite the recent development of molecular-targeted treatment and immunotherapy, survival of patients with esophageal adenocarcinoma (EAC) with poor prognosis is still poor due to lack of an effective biomarker. In this study, we aimed to explore the ceRNA and construct a multivariate gene expression predictor model using data from The Cancer Genome Atlas (TCGA) to predict the prognosis of EAC patients. Methods: We conducted differential expression analysis using mRNA, miRNA and lncRNA transciptome data from EAC and normal patients as well as corresponding clinical information from TCGA database, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of those unique differentially expressed mRNAs using the Integrate Discovery Database (DAVID) database. We then constructed the lncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network of EAC and used Cox proportional hazard analysis to generate a multivariate gene expression predictor model. We finally performed survival analysis to determine the effect of differentially expressed mRNA on patients' overall survival and discover the hub gene. Results: We identified a total of 488 lncRNAs, 33 miRNAs, and 1207 mRNAs with differentially expressed profiles. Cox proportional hazard analysis and survival analysis using the ceRNA network revealed four genes (IL-11, PDGFD, NPTX1, ITPR1) as potential biomarkers of EAC prognosis in our predictor model, and IL-11 was identified as an independent prognostic factor. Conclusions: In conclusion, we identified differences in the ceRNA regulatory networks and constructed a four-gene expression-based survival predictor model, which could be referential for future clinical research.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Multivariate gene expression‐based survival predictor model in esophageal adenocarcinoma

et al. 2020

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“…For example, Wang et al found that IL-23 promotes the development of gastritis, which might lead to gastric cancer [147], and Li et al found that IL-23 can also promote the metastasis of liver cancer [148]. Yang et al [149] and Lay et al [150] found that IL-11 is involved in the development of esophageal squamous cell carcinoma and endometrial cancer. In addition, some scientists have found that IL-17A can promote the formation of tumor blood vessels [151, 152], thereby contributing to the proliferation and invasion of tumor cells.…”

Section: Proinflammatory Factors and Inflammatory Factors In Chronic mentioning

confidence: 99%

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

2019

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A strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large number of inflammatory factors and inflammatory cells in the tumor microenvironment, and tumor-promoting immunity and anti-tumor immunity exist simultaneously in the tumor microenvironment. The typical relationship between chronic inflammation and tumor has been presented by the relationships between Helicobacter pylori, chronic gastritis, and gastric cancer; between smoking, development of chronic pneumonia, and lung cancer; and between hepatitis virus (mainly hepatitis virus B and C), development of chronic hepatitis, and liver cancer. The prevention of chronic inflammation is a factor that can prevent cancer, so it effectively inhibits or blocks the occurrence, development, and progression of the chronic inflammation process playing important roles in the prevention of cancer. Monitoring of the causes and inflammatory factors in chronic inflammation processes is a useful way to predict cancer and assess the efficiency of cancer prevention. Chronic inflammation-based biomarkers are useful tools to predict and prevent cancer.

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“…Although multiple tools for cancer diagnosis and therapy have developed rapidly, ESCC has high incidence and recurrence rates and is still difficult to detect in the early stages (Huang and Yu, 2018). In addition, the lack of significant change in the overall 5-year survival rate calls for new and sensitive tools for ESCC diagnosis and therapy (Yang et al, 2019). Xing et al (2020) observed that circ-Foxo3, play vital physiological roles in ESCC tissues and cell lines via molecular and functional experiments in vivo and in vitro.…”

Section: Esophageal Squamous Cell Cancermentioning

confidence: 99%

“…The expression of circ-Foxo3 in various cancers has been tested and compared, and the expression trends of circ-Foxo3 in different cancers are not completely consistent. For example, the expression of circ-Foxo3 in BC (Nair et al, 2016), EC (Yang et al, 2019), lung cancer (Zhang Y. et al, 2018) and bladder cancer (Wang C. et al, 2019) is downregulated, while circ-Foxo3 is usually overexpressed in GC (Sun et al, 2014) and glioma (Zhang et al, 2019) compared with normal controls. However, circ-Foxo3 expression and its specific function in PCa are controversial and remain to be further studied.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Circular RNA Foxo3: A Promising Cancer-Associated Biomarker

Yang

Zhao

et al. 2021

Front. Genet.

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Circular RNAs (circRNAs) are a class of novel non-coding RNAs (ncRNAs). Emerging evidence demonstrates that circRNAs play crucial roles in many biological processes by regulating linear RNA transcription, downstream gene expression and protein or peptide translation. Meanwhile, recent studies have suggested that circRNAs have the potential to be oncogenic or anti-oncogenic and play vital regulatory roles in the initiation and progression of tumors. Circular RNA Forkhead box O3 (circ-Foxo3, hsa_circ_0006404) is encoded by the human FOXO3 gene and is one of the most studied circular RNAs acting as a sponge for potential microRNAs (miRNAs) (Du et al., 2016). Previous studies have reported that circ-Foxo3 is involved in the development and tumorigenesis of a variety of cancers (bladder, gastric, acute lymphocytic leukemia, glioma, etc.). In this review, we summarize the current studies concerning circ-Foxo3 deregulation and the correlative mechanism in various human cancers. We also point out the potential clinical applications of this circRNA as a biomarker for cancer diagnosis and prognosis.

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IL-11 activated by lnc-ATB promotes cell proliferation and invasion in esophageal squamous cell cancer

Cited by 12 publications

References 39 publications

Multivariate gene expression‐based survival predictor model in esophageal adenocarcinoma

Multivariate gene expression‐based survival predictor model in esophageal adenocarcinoma

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

Circular RNA Foxo3: A Promising Cancer-Associated Biomarker

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