IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26

Conti, Pio; Kempuraj, D; Frydas, S.; Kandere, Kristiana; Boucher, William; Létourneau, Richard; Madhappan, B; Sagimoto, K.; Christodoulou, Spyridon; Theoharides, T.C.

doi:10.1016/s0165-2478(03)00087-7

Cited by 83 publications

(51 citation statements)

References 28 publications

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“…Finally, TGF and additional members of the IL-10 subfamily, which were not investigated here, may have influenced PBC proliferation. 1,30 Therefore, we believe that the reduced genetic effect observed was due to substantial confounding factors.…”

Section: Discussionmentioning

confidence: 96%

Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen

et al. 2004

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Since interleukin (IL)-10 is a key mediator of immunosuppression, and immunosuppression is considered an important element of helminth infection, we studied variants of the putative IL-10 gene promoter in 337 individuals from 130 families heavily exposed to infection by the tissue nematode Onchocerca volvulus. As shown by transmission disequilibrium tests, variants of the IL-10 promoter at positions -1082(G/A), -819(C/T), and -592(C/A) in the haplotype of ATA were significantly associated with high peripheral blood cell (PBC) proliferative responses to O. volvulus antigen (OvAg). No associations were observed using phytohemagglutinin-induced PBC proliferation or with qualitative or quantitative phenotypes of onchocerciasis or onchocerciasis-related skin disease. The findings are compatible with the hypothesis that the ATA haplotype causes a decrease in IL-10 production by OvAg-reactive type-1 regulatory T-lymphocytes, thereby alleviating the suppression of other T cells. To our knowledge, this is the first time that an influence of IL-10 promoter variants is shown on the adaptive immune response.

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Section: Discussionmentioning

confidence: 96%

Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen

et al. 2004

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“…These data indicated that this particular monocyte response to IL-19, the induction of IL-10 production, does not require help from other cellular subsets. Thus, IL-19 is produced by and acts upon the monocyte population [19]. It is interesting to note that during a recent study examining IL-10-family receptor-subunit expression, the IL-20R1 chain of the IL-19 receptor could not be detected on human monocytes [23].…”

Section: Il-19-induced Il-10 Is Produced By Monocytesmentioning

confidence: 99%

“…In recent years, five novel cytokines that are structurally related to IL-10 have been identified [14][15][16][17][18]. These cytokines constitute the 'IL-10 family', consisting of IL-10 itself, IL-19, IL-20, IL-22, IL-24 and IL-26 [19][20][21][22][23]. Unlike IL-10, however, knowledge of the biological functions of the IL-10 family members is currently poor, especially in relation to function within the immune system.…”

Section: Introductionmentioning

confidence: 99%

Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10

et al. 2005

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IL‐19 is a novel, recently identified member of the IL‐10 family of cytokines. We identified IL‐10 as a cytokine that was strongly induced in IL‐19‐stimulated PBMC. IL‐19‐induced IL‐10 secretion was dose‐dependent and could be detected in culture supernatants after 3 h of stimulation. Furthermore, quantitative RT‐PCR analysis demonstrated that IL‐19 stimulation increased the level of IL‐10 mRNA present within cells, suggesting that IL‐19 is a transcriptional activator of IL‐10. IL‐19 was also able to induce its own expression, with IL‐10 potently down‐regulating this IL‐19 ‘auto‐induction’. LPS induction of IL‐19 expression was also regulated by IL‐10, demonstrating that IL‐10 is likely an important regulator of human IL‐19 induction. Maturation of dendritic cells from human PBMC in the presence of IL‐19 resulted in an increase in IL‐10 levels within these cells, whereas IL‐12 was not affected. These results advance our understanding of the function of this novel cytokine and its regulation within the human immune system, in addition to providing a new insight into the control of the important immunoregulatory cytokine, IL‐10.

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“…IL-10 has well documented immune inhibitory capacity. IL-10 was originally called "cytokine synthesis inhibiting factor," because it can inhibit the transcription and translation of a variety of inflammatory cytokines (4). IL-10 reduces antigen presentation and either inhibits (5) or biases (6) T-cell activation.…”

mentioning

confidence: 99%

NF-κB1 (p50) Homodimers Differentially Regulate Pro- and Anti-inflammatory Cytokines in Macrophages

Cao

Zhang

Edwards

et al. 2006

Journal of Biological Chemistry

333

277

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NF-B/Rel is a family of transcription factors whose activation has long been linked to the production of inflammatory cytokines. Here, we studied NF-B signaling in the regulation of the anti-inflammatory cytokine, interleukin-10 (IL-10). We identified a role for a single NF-B family member, NF-B1 (p50), in promoting the transcription of IL-10. The NF-B ciselement on IL-10 proximal promoter was located to ؊55/؊46, where p50 can homodimerize and form a complex with the transcriptional co-activator CREB-binding protein to activate transcription. The other Rel family members appear to play a negligible role in IL-10 transcription. Mice lacking p50 were more susceptible to lethal endotoxemia, and macrophages taken from p50 ؊/؊ mice exhibit skewed cytokine responses to lipopolysaccharide, characterized by decreased IL-10 and increased tumor necrosis factor and IL-12. Taken together, our studies demonstrate that NF-B1 (p50) homodimers can be transcriptional activators of IL-10. The reciprocal regulation of pro-and antiinflammatory cytokine production by NF-B1 (p50) may provide potential new ways to manipulate the innate immune response.

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IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26

Cited by 83 publications

References 28 publications

Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen

Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen

Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10

NF-κB1 (p50) Homodimers Differentially Regulate Pro- and Anti-inflammatory Cytokines in Macrophages

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