IL-10 Promoter Genetic Polymorphisms and Risk of Kawasaki Disease in Taiwan

Abstract

Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (−1082, −819, and −592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci −819 T > C and −592 A > C for KD cases was observed (Ppermutation = 0.029 and Ppermutation = 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p = 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090–2.443; Ppermutation = 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. {The haplotype CC (−819, −592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987–1.797; p = 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant, p = 0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and −592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study.

Increased Risk of Atopic Dermatitis in Preschool Children with Kawasaki Disease: A Population-Based Study in Taiwan

“…Several lines of evidence have shown an imbalance between Th1 and Th2 immune reactions in KD patients. Th1 immune related responses (IFN-gamma, tumor necrosis factor-alpha, IL-1 β , and IL-10) [38, 39] and Th2 immune related responses (eosinophils, IL-4 [22], IL-5 [25, 26], eotaxin, and total IgE) have been reported to be associated with the susceptibility to KD and disease outcomes. Furthermore, serum IgE levels were shown to be increased in KD patients during the acute stage of the disease [34].…”

Meta-Analysis of Associations Between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis

“…Thus, we analyzed these groups independently. Accordingly, a total of 21 separate comparisons were considered in this metaanalysis, which included 4121 cases and 5504 controls and consisted of European, Asian, Turkish, and Middle Eastern populations (Ates et al, 2010;Bartfai et al, 2003;Boiardi et al, 2006;Dilek et al, 2009;Hsieh et al, 2011;Hsueh et al, 2009;Lin et al, 2014;Montes-Cano et al, 2013;Menegatti et al, 2009;Murakozy et al, 2001;Mizuki et al, 2010;Rueda et al, 2007;Shahram et al, 2011;Spriewald et al, 2005;Wallace et al, 2007;Wu et al, 2014;Yang et al, 2003) (Table 1). Thus, an ethnicity-specific meta-analysis was conducted for these populations, respectively.…”

“…Thus, a number of studies have examined the association between IL-10 polymorphisms and vasculitis, but the reported results are contradictory, possibly because of the low statistical power of individual studies (Ates et al, 2010;Bartfai et al, 2003;Boiardi et al, 2006;Dilek et al, 2009;Hsieh et al, 2011;Hsueh et al, 2009;Lin et al, 2014;Montes-Cano et al, 2013;Menegatti et al, 2009;Murakozy et al, 2001;Mizuki et al, 2010;Rueda et al, 2007;Shahram et al, 2011;Spriewald et al, 2005;Wu et al, 2014;Wallace et al, 2007;Yang et al, 2003). Therefore, in order to overcome the limitations of individual studies, resolve inconsistencies, and reduce the likelihood of random errors that are responsible for false-positive or false-negative associations (Lee et al, 2010(Lee et al, , 2007Nath et al, 2005;Song & Lee, 2014), we turned to meta-analysis.…”

CD40Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population

“…Several reports have indicated that genetic polymorphisms may contribute to the susceptibility and disease severity of KD. For example, polymorphisms in the genes including IL-10, CASP3, IL-18, and inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) have been reported to be involved in the development of KD [22][23][24][25][26]. In 2004, Onouchi and colleagues were the first group reporting the association between CD40L gene polymorphisms and KD [27].…”