IL-10 Producing Regulatory B Cells in Mice and Humans: State of the Art

Bouaziz, Jean‐David; Buanec, Hélène Le; Saussine, A.; Bensussan, Armand; Bagot, Martine

doi:10.2174/156652412800620057

Cited by 57 publications

(32 citation statements)

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“…One of these cell populations are Bregs, which are characterized by their ability to inhibit, in an antibody-independent fashion, immune reactions in vitro and in vivo (Bouaziz et al, 2012;Corcione et al, 2006;Mauri and Bosma, 2012). The main mechanism of Breg action involves the production of IL-10.…”

Section: Discussionmentioning

confidence: 99%

“…However, a population of B cells that regulate immune responses independently of antibody production has been described (Bouaziz et al, 2012;Matsushita and Tedder, 2011;Mauri and Bosma, 2012). These B cells inhibit immune reactions mainly by the production of IL-10 and are termed regulatory B cells (Bregs) or B10 cells (Bouaziz et al, 2012;DiLillo et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-γ-treated mesenchymal stem cells

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-γ-treated mesenchymal stem cells

et al. 2016

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“…Previous in vitro studies demonstrated that these cells exert control over CD4+ T-cell activation and proliferation [26] and in mice, they downregulate inflammation [27]. Blair et al [14] demonstrated that transitional B-cells express CD5, and age had a significant effect on the CD5+ B-cell counts in CMV-seropositive males only [23].…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Infection Minimally Affects the Frequencies of B-Cell Phenotypes in Peripheral Blood of Younger and Older Adults

Goldeck¹,

Oettinger²,

Janssen³

et al. 2016

Gerontology

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Background: An accumulation of late-differentiated CD8+ T-cells together with fewer B-cells and seropositivity for cytomegalovirus (CMV) characterises an ‘immune risk profile' associated with mortality in elderly people and represents one of the hallmarks of ‘immunosenescence'. Objectives: While differences in memory T-cell phenotypes between young and old people have been intensively studied, and the role of CMV is well-accepted as a driving force in this regard, the impact of CMV on B-cells, if any, has been relatively neglected thus far. Methods: Here, we avail ourselves of blood samples from participants of the Berlin Aging Study II (BASE-II) to compare peripheral blood B-cell differentiation phenotypes of 140 age- and gender-matched CMV-seronegative or -seropositive adults aged between 24 and 85 years using multicolour flow cytometry analysis. Results: We found that the frequencies of naïve B-cells within the CD19+ population were not significantly different in younger and older CMV-seronegative people. This was also true in CMV-seropositive subjects. The frequencies of late-differentiated B-cells were also not different in CMV-negative elderly and young. However, in marked contrast to the T-cell compartment, this was also true for late differentiated B-cells. Within age groups, the most marked differences in the distribution of B-cell phenotypes were between CMV-seronegative and -seropositive subjects, for both genders. Conclusion: These results emphasize the importance of including CMV serostatus in the analysis of immune signatures. Because the proportion of the population infected with CMV increases with age, the effect of CMV rather than age could confound analyses seeking age-associated changes to human immunity.

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“…Possibly comprised in the immature transitional B-cell population, regulatory B cells (Bregs) have been described for their ability to secrete IL-10 [95]. CD19 þ CD10 þ CD27 À CD24 high CD38 high IL-10 þ Bregs suppress pro-inflammatory cytokine secretion by monocytes and CD4 þ T cells.…”

Section: Production Of Interleukin-10 Characterizes Regulatory B Cellsmentioning

confidence: 99%

Impairment of B-cell functions during HIV-1 infection

Amu

Ruffin

Réthi

et al. 2013

Aids

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A variety of B-cell dysfunctions are manifested during HIV-1 infection, as reported early during the HIV-1 epidemic. It is not unusual that the pathogenic mechanisms presented to elucidate impairment of B-cell responses during HIV-1 infection focus on the impact of reduced T-cell numbers and functions, and lack of germinal center formation in lymphoid tissues. To our understanding, however, perturbation of B-cell phenotype and function during HIV-1 infection may begin at several different B-cell developmental stages. These impairments can be mediated by intrinsic B-cell defects as well as by the lack of proper T-cell help. In this review, we will highlight some of the pathways and molecular interactions leading to B-cell impairment prior to germinal center formation and B-cell activation mediated through the B-cell receptor in response to HIV-1 antigens. Recent studies indicate a regulatory role for B cells on T-cell biology and immune responses. We will discuss some of these novel findings and how these regulatory mechanisms could potentially be affected by the intrinsic defects of B cells taking place during HIV-1 infection.

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IL-10 Producing Regulatory B Cells in Mice and Humans: State of the Art

Cited by 57 publications

References 0 publications

Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-γ-treated mesenchymal stem cells

Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-γ-treated mesenchymal stem cells

Cytomegalovirus Infection Minimally Affects the Frequencies of B-Cell Phenotypes in Peripheral Blood of Younger and Older Adults

Impairment of B-cell functions during HIV-1 infection

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