IL‐10 polymorphisms and T‐cell subsets could affect the clinical presentation and outcome of childhood immune thrombocytopenia in Egyptian population

Soliman, Mohamed A.; Helwa, Mohamed A; Fath-Allah, Samar K.; El-Hawy, Mahmoud A.; Badr, Hassan; Barseem, Naglaa Fathy

doi:10.1111/apm.12823

Cited by 10 publications

(6 citation statements)

References 46 publications

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“…The possible involvement of this cytokine in ITP has been deeply investigated over the years. In particular, several authors found a correlation between the IL-10 (-1082) polymorphism, which is associated with an impairment in general cytokine release, and the acute form of ITP [36,37,38,39,40]. It is known that both CB1 and CB2 receptors can influence the production of IL-10.…”

Section: The Ec System In Immune Thrombocytopeniamentioning

confidence: 99%

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases

Argenziano

Tortora

Bellini

et al. 2019

IJMS

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Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. CB2, to a great extent, and CB1, to a lesser extent, are involved in regulating the immune response. They also regulate the inflammatory processes by inhibiting pro-inflammatory mediator release and immune cell proliferation. This review provides an overview on the role of the endocannabinoid system with a major focus on cannabinoid receptors in the pathogenesis and onset of inflammatory and autoimmune pediatric diseases, such as immune thrombocytopenia, juvenile idiopathic arthritis, inflammatory bowel disease, celiac disease, obesity, neuroinflammatory diseases, and type 1 diabetes mellitus. These disorders have a high social impact and represent a burden for the healthcare system, hence the importance of individuating more innovative and effective treatments. The endocannabinoid system could address this need, representing a possible new diagnostic marker and therapeutic target.

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Section: The Ec System In Immune Thrombocytopeniamentioning

confidence: 99%

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases

Argenziano

Tortora

Bellini

et al. 2019

IJMS

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“…49,50 The presence of these polymorphisms can disturb the tolerance of the immune system to its antigens. 51,52 We discuss several studies on IL-10 polymorphisms in ►Table 7.…”

Section: Discussionmentioning

confidence: 99%

rs1800890 Polymorphism of IL-10 and Susceptibility to Idiopathic Thrombocytopenic Purpura

Zeylabi,

Jalali,

Kaydani

et al. 2023

J Pediatr Genet

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Immune thrombocytopenic purpura (ITP) is an immune bleeding disorder that is reported in approximately 2 out of every 100,000 adults with a mean age of 50 years. Several factors such as various genetic backgrounds are associated with the pathogenesis of ITP. Interleukin (IL)-10 is a complicated cytokine that has a role in tumor progression, antitumor immunity, and immune system regulation. rs1800890 is an IL-10 single nucleotide polymorphism linked to lower levels of IL-10. A total of 67 patients with ITP and 70 healthy individuals (controls) were considered in this study. The IL-10 polymorphism was detected by the amplification refractory mutation system–polymerase chain reaction technique. According to our analysis, individual carriers of the AA genotype were less likely to develop ITP. The AT genotype was more common in patients with ITP in comparison to the control group. However, there was no significant association between rs1800890 genotypes (p = 0.775, odds ratio =1.517, 95%) in the acute and chronic groups. We observed that women had a higher mean frequency of this polymorphism (p = 0.0012). The rs1800890 AA genotype was associated with the highest platelet counts. However, the mean platelet volume and platelet distribution width values among alleles of the polymorphisms did not vary significantly. The IL-10 rs1800890 polymorphism may have a role in idiopathic thrombocytopenic purpura etiology. As a result, more research with a larger number of sample sizes is suggested.

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“…11,25 The TT genotype carriers of IL-10 rs1800896 and rs1800872 were reported to be lined with lower proportion of CD4 cells and higher proportion of CD8 cells, lower CD4/CD8 ratio and lower T-reg frequency. 28,29 The imbalance of lymphocyte subsets reflected a dysregulated state of immune system, which was predominantly involved in AA. 4,30 Our results accordingly showed that rs1800896 TT genotype was positively associated with AA susceptibility compared with CT + CC carriers.…”

Section: Discussionmentioning

confidence: 99%

“…The production of IL‐10 was considered to be strongly influenced by the genetic background and had pleiotropic effects on the immune system, the A‐A‐G‐C‐C haplotype is associated with decreased production of interleukin‐10 while the T‐C‐A‐T‐A haplotype is defined by high levels of interleukin‐10 11,25 . The TT genotype carriers of IL‐10 rs1800896 and rs1800872 were reported to be lined with lower proportion of CD4 cells and higher proportion of CD8 cells, lower CD4/CD8 ratio and lower T‐reg frequency 28,29 . The imbalance of lymphocyte subsets reflected a dysregulated state of immune system, which was predominantly involved in AA 4,30 .…”

Section: Discussionmentioning

confidence: 99%

Interleukin‐10 promoter variability is associated with the susceptibility, severity, and clinical outcomes of aplasitc anemia in Han‐Chinese population

Wang

You

et al. 2022

Int J Lab Hematology

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Introduction: Acquired aplastic anemia (AA), a heterogeneous bone marrow (BM) failure disease, is mainly mediated by the immune destruction of hematopoietic stem cells (HSCs). Given the predominant role of immunosuppressive therapy (IST) in AA, it is sensible to theorize that variants of cytokine genes might affect the outcome of IST.Methods: In this study, we analyzed three single nucleotide polymorphisms (SNPs) of interleukin (IL)-10 gene in promoter region to clarify their relationship with susceptibility, clinical efficacy and prognosis of AA. Results:We observed that CT genotype of IL-10 rs1800896 was associated with a decreased risk of AA (adjusted OR = 0.541 [95% CI 0.295-0.993], p = .047). Besides, the disease severity differed considerably by IL-10 gene promoter genotypes and alleles. Furthermore, IL-10 SNPs influenced efficacy of IST, with unfavorable response exhibited by rs1800871 and rs1800872 in dominant models (GG + AG vs. AA, adjusted OR = 0.409 [95% CI 0.178-0.943, p = .036] for rs1800871 and GG + GT vs. TT, adjusted OR = 0.396 [95% CI 0.173-0.909, p = .028] for rs1800872, respectively). Conclusion:The polymorphisms of IL-10 promoter region were informatively genetic risk factors which might be conducive to the insights into the mechanisms of AA and the design of individual regimens.

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IL‐10 polymorphisms and T‐cell subsets could affect the clinical presentation and outcome of childhood immune thrombocytopenia in Egyptian population

Cited by 10 publications

References 46 publications

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases

The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases

rs1800890 Polymorphism of IL-10 and Susceptibility to Idiopathic Thrombocytopenic Purpura

Interleukin‐10 promoter variability is associated with the susceptibility, severity, and clinical outcomes of aplasitc anemia in Han‐Chinese population

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