IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response

Adris, Soraya; Klein, S; Jasnis, María A.; Chuluyan, Eduardo; Ledda, M. F.; Bravo, Alicia; Carbone, Cecilia; Chernajovsky, Yuti; Podhajcer, Osvaldo L.

doi:10.1038/sj.gt.3301012

Cited by 63 publications

(53 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Traditionally, Th1 have been thought to be associated with cellmediated immunity and Th2 to be related to humoral immunity. However, both types of T cells have been shown to participate in the antitumor immune response (37)(38)(39)(40)(41)(42). The heterogeneity of cytokine profiles has been extensively demonstrated (43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

The Kinetics of In Vivo Priming of CD4 and CD8 T Cells by Dendritic/Tumor Fusion Cells in MUC1-Transgenic Mice

Koido

Tanaka

Chen

et al. 2002

The Journal of Immunology

View full text Add to dashboard Cite

Previous work has demonstrated that dendritic/tumor fusion cells induce potent antitumor immune responses in vivo and in vitro. However, little is known about the migration and homing of fusion cells after s.c. injection or the kinetics of CD4+ and CD8+ T cell activation. In the present study, fluorescence-labeled dendritic/MUC1-positive tumor fusion cells (FC/MUC1) were injected s.c. into MUC1-transgenic mice. The FC/MUC1 migrated to draining lymph nodes and were closely associated with T cells in a pattern comparable with that of unfused dendritic cells. Immunization of MUC1-transgenic mice with FC/MUC1 resulted in proliferation of T cells and induced MUC1-specific CD8+ CTL. Moreover, CD4+ T cells activated by FC/MUC1 were multifunctional effectors that produced IL-2, IFN-γ, IL-4, and IL-10. These findings indicate that both CD4+ and CD8+ T cells can be primed in vivo by FC/MUC1 immunization.

show abstract

Section: Discussionmentioning

confidence: 99%

The Kinetics of In Vivo Priming of CD4 and CD8 T Cells by Dendritic/Tumor Fusion Cells in MUC1-Transgenic Mice

Koido

Tanaka

Chen

et al. 2002

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…Contrasting these findings, local release of IL-10 from transfected tumor cells (7)(8)(9)(10) or therapeutic administration of IL-10 induces strong antitumor immune responses and leads to tumor rejection in a variety of mouse tumor models (11)(12)(13).…”

Section: Introductionmentioning

confidence: 87%

“…We and others have previously shown that the antitumor effect of IL-10 depends on CD8 þ T cells (7,9,10,12). In vitro, IL-10 induces the proliferation and cytotoxic activity of CD8 þ T cells and is a chemoattractant for CD8 þ T cells (14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells withoutDe NovoInfiltration from Secondary Lymphoid Organs

et al. 2012

View full text Add to dashboard Cite

show abstract

“…For example, limited data from mechanistic studies suggest that, in contrast to the inflammatory markers described above, both IL10 and IL12 reduce colorectal cancer progression (58,59). At the same time, calcitriol seems to decrease levels of these cytokines (60,61).…”

Section: Tgfb1mentioning

confidence: 99%

Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies

Harten-Gerritsen

Balvers

Witkamp

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Survival from colorectal cancer is positively associated with vitamin D status. However, whether this association is causal remains unclear. Inflammatory processes may link vitamin D to colorectal cancer survival, and therefore investigating inflammatory markers as potential mediators may be a valuable next step. This review starts with an overview of inflammatory processes suggested to be involved in colorectal cancer progression and regulated by vitamin D. Next, we provide recommendations on how to study inflammatory markers in future epidemiologic studies on vitamin D and colorectal cancer survival. Mechanistic studies have shown that calcitriol-active form of vitamin Dinfluences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kB pathway, and the expression of the cytokines TNFa, IL1b, IL6, IL8, IL17, and TGFb1. Based on this and taking into account methodologic issues, we recommend to include analysis of specific soluble peptides and proteins, such as cytokines, in future epidemiologic studies on this issue. Vitamin D and the markers should preferably be measured at multiple time points during disease progression or recovery and analyzed using mediation analysis. Including these markers in epidemiologic studies may help answer whether inflammation mediates a causal relationship between vitamin D and colorectal cancer survival. Cancer Epidemiol Biomarkers Prev; 24(12); 1820-8. Ó2015 AACR.

show abstract

IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response

Cited by 63 publications

References 39 publications

The Kinetics of In Vivo Priming of CD4 and CD8 T Cells by Dendritic/Tumor Fusion Cells in MUC1-Transgenic Mice

The Kinetics of In Vivo Priming of CD4 and CD8 T Cells by Dendritic/Tumor Fusion Cells in MUC1-Transgenic Mice

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells withoutDe NovoInfiltration from Secondary Lymphoid Organs

Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies

Contact Info

Product

Resources

About